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Biomedical subjects

S McCarthy

Publications and source records attributed to S McCarthy.

At least 127 records · Page 7Linked to original sources
PubMed1983

Sonography of vaginal masses.

The utility of sonography in the evaluation of the internal anatomy of the female pelvis is well established, but little has been reported on the characterization of vaginal masses. This report includes several cases representative of the sonographic appearances of such masses. Gartner duct cyst, hematocolpos, and urine refluxed into the vagina all have a similar cystic appearance. However, Gartner duct cysts are distinguishable from the latter via identification of a cyst wall separate from the vaginal wall. Solid lesions described include the common menstrual tampon, since its sonographic appearance relates to the amount of contained air. Prolapsing fibromyomas can be diagnosed via the contiguous uterine component. Also reported is the previously undescribed appearance of neurofibromas involving the vagina.

Adolescent↗
PubMed1983

Phase I study of Wellferon (human lymphoblastoid alpha-interferon) as cancer therapy: clinical results.

Thirty-three patients with advanced malignancy were treated with Wellferon. Doses ranging from 0.75 X 10(6) to 50 X 10(6) U were administered intramuscularly every 12 h for a 7-day course of therapy. Courses were repeated every 4 weeks as a function of tumor response. Toxicity resulted in fever, chills, malaise, leukopenia, thrombocytopenia, nausea and/or vomiting, diarrhea, hepatocellular damage, and, in a single case, gastrointestinal bleeding (which was a possible cause of patient death). Toxicity tended to increase with increasing dose, and 30 X 10(6) units every 12 h for 7 days was considered to be the maximally tolerated dose. Partial responses were seen in three patients with diagnoses of renal cell carcinoma, diffuse histocytic lymphoma, and Hodgkin's disease. Minimal responses were seen in four patients with diagnoses of chronic lymphocytic leukemia, multiple myeloma (two patients), and breast cancer. Positive response to therapy did not correlate with dose level.

Cell Survival↗
PubMed1983

Giant retroperitoneal neurilemoma: a rare cause of digestive tract symptoms.

Benign giant retroperitoneal neurilemoma is a rare tumor which may cause gastrointestinal symptoms. An unusual case that recurred 12 years after initial excision is detailed here. Clinicians should, in selected cases, consider the possibility of a primary retroperitoneal tumor in the differential diagnosis of GI tract signs and symptoms, when primary gastrointestinal disease is not demonstrated. Primary retroperitoneal tumors are practically symptomless in early stages and are insidious in their growth patterns. Later stages of the tumors are capable of causing an array of digestive tract disturbances which may include ascites and GI blood loss. Computed axial tomographic studies have supplanted traditional diagnostic techniques, with angiography recommended in selective cases to define the blood supply. The pathology of neurilemoma and the spectrum of primary mesenchymal nonepithelial retroperitoneal tumors are presented.

Abdomen↗
PubMed1981

Biliary lipid, bile acid composition, and dietary correlations in Micmac Indian women. A population study.

The precursor state for cholesterol gallstone formation is cholesterol-saturated bile. We studied a high-risk group for cholesterol gallstones to determine whether dietary variables affect bile cholesterol. Bile samples were analyzed from 46 Micmac Indian women without gallstones and 13 with gallstones for molar percentage cholesterol (MPC) and bile acid composition. The data were analyzed by multiple regression analysis with MPC as the dependent variable and the dietary variables, obtained from four consecutive-day food records, and biliary bile acid composition as the independent variables. In the 46 women without gallstones, obesity, calorie range/calorie intake, and iron and calcium intake were, in their order of importance, significant factors. In normal weight subjects (ponderal index > 12.5) relative obesity was still a significant correlate. Obesity and iron intake were positive correlates while calorie range/calorie intake and calcium intake varied inversely. When the effect of obesity was controlled, these factors were still significant in this group, as they were in the gallstone group. In addition, the duration of overnight fast obtained by history, together with the proportions of deoxycholic and chenodeoxycholic acids in bile were correlates of the biliary molar percentage cholesterol.

Adolescent↗
PubMed1975

Computer diagnosis of labor progression.

Abnormal labor has been suspected of being inherently delectorious to the fetus. In order to explore this problem, clinical factors, labor progress, and fetal monitoring parameters were compared in matched groups of high-risk patients whose fetuses were in theoccipitoposterior (0P) and occipitoanterior postions. The OP group showed significant excesses of dysfunctional labor aptterns, uterine contraction pattern abnormalities, and late and variabl fetal heart rate decelerations not accounted for by theuse of oxytocin or the presence of cord problems. In OP labor, lower Apgar scores were associated withasignificant excess of preceding fetal heart rate decelerations independant of operative delivery. This study suggests that neonatal depression in OP laboris related to intrapartum factors preceding delivery and provides direct support for theconcept that abnormal labor may adversely affect the fetus. The OP position is an indication for close fetomaternal supervision during labor.

Adolescent↗
PubMedDate not supplied

Cystic adenomyosis of the uterus: MRI.

Adenomyosis of the uterus is most often seen as focal or diffuse thickening of the myometrial junctional zone on MRI. We describe the morphologic features and signal characteristics of the rarer cystic form of the disease, as revealed by MRI. We conclude that cystic adenomyosis of the uterus is characterized by a well-circumscribed cystic lesion within the myometrium that demonstrates hemorrhage in differential stages of organization on MR images.

Adolescent↗