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S Mau

Publications and source records attributed to S Mau.

At least 19 recordsLinked to original sources
PubMed2002

ICP is lower during propofol anaesthesia compared to isoflurane and sevoflurane.

OBJECTIVES: Propofol is a cerebral vasoconstrictor while inhalation anaesthetics like isoflurane and sevoflurane act as cerebral vasodilators in both animal and human studies. This difference of action upon cerebral vessels might implicate a lower ICP during propofol anaesthesia. Cerebral metabolism is decreased by all three anaesthetics. In a prospective, randomised multicenter study ICP was compared during anaesthesia with propofol, isoflurane and sevoflurane. METHODS: 117 patients subjected to elective craniotomy for supratentorial tumour. Propofol: N = 41; isoflurane: N = 38; sevoflurane: N = 38. Nitrous oxide was omitted and all anaesthetics were supplemented with a continuous infusion of fentanyl. ICP was measured subdurally after removal of the bone flap. MABP, CPP, PCO2, AVDO2, rectal temperature, tumour size and midline shift were registered too. STATISTICS: Kruskal-Wallis Variance on Ranks. All values in medians with range. P < 0.05 was considered significant. RESULTS: ICP (mmHg): propofol 7 (-1-20), isoflurane 12 (1-29), sevoflurane 11 (2-32). ICP was significantly lower in the propofol group compared to the isofluane and sevoflurane groups. CPP (mmHg): propofol 80 (45-104), isoflurane 60 (32-84), sevoflurane 63 (44-77). CPP was significantly higher in the propofol group compared to the isoflurane and sevoflurane groups. AVDO2 (mmol/l): propofol 3.1 (0.9-5.1), isoflurane 2.5 (1.1-4.5), sevoflurane 2.6 (0.8-4.1). AVDO2 was significantly higher in the propofol group compared to the isoflurane and sevoflurane groups. No significant differences in PCO2, rectal temperature, tumour size and midline shift were found. CONCLUSIONS: Subdural ICP is significantly lower during propofol anaesthesia compared to isoflurane and sevoflurane anaesthesia. CPP and AVDO2 are significantly higher during propofol anaesthesia compared to isoflurane and sevoflurane anaesthesia.

Adult↗
PubMed1992

Activation of protein kinase C in permeabilized human neuroblastoma SH-SY5Y cells.

The activation of protein kinase C was investigated in digitonin-permeabilized human neuroblastoma SH-SY5Y cells by measuring the phosphorylation of the specific protein kinase C substrate myelin basic protein4-14. The phosphorylation was inhibited by the protein kinase C inhibitory peptide PKC19-36 and was associated to a translocation of the enzyme to the membrane fractions of the SH-SY5Y cells. 1,2-Dioctanoyl-sn-glycerol had no effect on protein kinase C activity unless the calcium concentration was raised to concentrations found in stimulated cells (above 100 nM). Calcium in the absence of other activators did not stimulate protein kinase C. Phorbol 12-myristate 13-acetate was not dependent on calcium for the activation or the translocation of protein kinase C. The induced activation was sustained for 10 min, and thereafter only a small net phosphorylation of the substrate could be detected. Calcium or dioctanoylglycerol, when applied alone, only caused a minor translocation, whereas in combination a marked translocation was observed. Arachidonic acid (10 microM) enhanced protein kinase C activity in the presence of submaximal concentrations of calcium and dioctanoylglycerol. Quinacrine and p-bromophenacyl bromide did not inhibit calcium- and dioctanoylglycerol-induced protein kinase C activity at concentrations which are considered to be sufficient for phospholipase A2 inhibition.

Acetophenones↗
PubMed1989

Binding and internalization of a iodinated substance P analog by cultured anterior pituitary cells.

Substance P binding to cultured anterior pituitary cells was characterized using Bolton-Hunter iodinated substance P as a ligand. At 0 degrees C, the interaction of the ligand and the cellular surface binding sites was found to be specific, rapid and reversible. Scatchard and Hill analysis of specific binding revealed a single class of non-interacting binding sites with a high affinity (KD = 0.48 nM) and a moderate density of binding sites (Bmax = 1187 binding sites/cell). At 37 degrees C a NaOH-soluble intracellular ligand pool was observed in addition to a surface-bound ligand pool released by a low pH buffer. Thus, substance P seems to be internalized after binding to cellular surface binding sites by means of receptor-mediated endocytosis. The internalization was rapid and could be blocked by colchicine (20 microM), an inhibitor of microtubuli assembly. Following internalization, intracellular degradation of the ligand could be demonstrated. Leupeptin (100 microM), an inhibitor of certain lysosomal enzymes could inhibit the cellular degradation of the added ligand, but had only a moderate influence on internalization. These results demonstrate that substance P after binding to a surface-localized receptor on its pituitary target cells is internalized and subsequently degraded by lysosomal enzymes.

Animals↗
PubMed1983

[High-voltage therapy of prostate cancer].

High-voltage therapy is becoming increasingly important as a form of individual differential therapy of carcinoma of the prostate. Around 40% of all patients with a diagnosis of carcinoma of the prostate can be treated with high-voltage therapy. The precondition is the absence of bone and soft-tissue metastases and of juxtaregional lymph-node metastases. Individual carcinoma therapy is based on pre-therapeutic tumor classification according to the TNM system. The 5-year survival rates are presented from a retrospective study carried out using primary radiation monotherapy and a combined hormone and radiation therapy; these figures were calculated by the life-table method. The study revealed no significant differences between the two forms of therapy as regards 5-year survival rates. The 5-year survival rates of all patients of the classifications T0-T3Nx-N2M0 irradiated (n: 198) (72% +/- 11% for hormone plus radiation therapy and 74% +/- 11% for radiation monotherapy) did not differ greatly from those of a normal male population of the same age (77%). High-voltage therapy of carcinoma of the prostate can thus be classified as a curative method of treatment.

Aged↗
PubMed1981

[Suppression of testicular testosterone production by irradiation of the testis in prostatic cancer].

Irradiation of the tests of 11 patients with carcinoma of the prostate in the age from 68 to 78 years with 20 Gy (5 X 2 Gy per week) decreased the plasma testosterone levels to an average of 70,3% of the initial values. After operative orchidectomy, however, a decrease of the plasma testosterone level to only 5% the values before operation was observed. Therefore, the operative orchidectomy cannot be replaced by the irradiation of the testes. Higher irradiation doses may cause skin injuries and there is the possibility of being a real carcinogen noxe for the irradiation region too.

Aged↗
PubMed1979

[Diagnostics and therapy of the carcinoma of the prostate (author's transl)].

By well organized preventive examinations early tumour stages can be recognized. The diagnosis of prostatic cancer has to be secured by biopsy. The primary reliability of aspiration biopsies (cytology) was 94% compared with punch biopsies (histology) amounting to 73%. Indications and results of aspiration biopsies, radiological and nuclear medical techniques in diagnosing prostatic cancer are described. The combined anti-androgenic hormonal therapy (infusions of cytonal, subcapsular orchiectomy, permanent administration of oestrogen) is considered to be the unchanged basis of treatment. Comparative cytologic investigations in therapy indicate that high-voltage treatment connected with hormonal therapy seems to be superior to exclusive hormonal treatment. Observations after additional therapy by a radionuclid (89-Strontium) for affecting metastases are encouraging. Indications of a therapy by cytostatica in progressive prostatic cancer are explained.

Antineoplastic Agents↗
PubMed1979

[Diagnosis and therapy of carcinoma of the cervix wtih metastasation and recurrence (author's transl)].

Reported in this paper are 201 patients who had been treated for carcinoma of the cervix with recurrence and metastasation, between 1960 and 1970. -- Three quarters of all cases had been irradiated before. Standardised methods of metaphylaxis are described together with their relevance to early detection of recurrence. Reference is made also to the present approach taken to carcinoma of the cervix with recurrence and metastasation following exclusive surgical treatment or surgery plus irradiation or exclusive irradiation. Various radiotherapies, surgical techniques, and methods of treatment, using cytostatics, are expounded.

Female↗