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Biomedical subjects

S Mattsson

Publications and source records attributed to S Mattsson.

At least 127 records · Page 7Linked to original sources
PubMed1980

Incidence of thrombosis after gynecologic surgery evaluated by an improved 125I-fibrinogen uptake test.

Two hundred and seventy-six women over 50 years of age who had gynecologic surgery were followed postoperatively with the 125I-fibrinogen uptake test (125I-FUT) to detect deep venous thrombosis (DVT). By using a newly devised technique based on conventional 125I-FUT, the exact depth of thrombi could be determined. The correlation between the results with our new technique and those from phlebography was almost 100%. Forty-seven (17%) of the women developed DVT postoperatively, 60% of them occurring in the calf muscle veins. Patients subjected to abdominal hysterectomies for malignant diseases had the highest incidence of DVT (36%), whereas those operated on for benign diseases with the same technique had the lowest (11%). Patients operated on for uterine prolapse had an intermediate DVT frequency of 15% but advanced age and estrogens given preoperatively increased the frequency. Neither the type of anesthesia (epidural or general), nor the duration of the operation, significantly influence the incidence of DVT in this study.

Age Factors↗
PubMed1980

A method for determination of the depth of thrombi after injection of fibrinogen labelled with iodine 125.

By using a specific characteristic of 125I decay, the depth of thrombi located in the lower limb could be determined. Twelve thrombi in nine patients were studied with the method and their localization was in all cases confirmed by phlebography and clinical examination. The results of the phlebograms were in good agreement with those of the 125I-fibrinogen method. The present method offers a promising alternative to phlebography in the diagnosis of postoperative thrombosis.

Aged↗
PubMed1980

Plutonium in [99mTc] Pertechnetate for clinical use: concise communication.

Pertechnetate from 31 different Tc-99m generators was analyzed to determine if alpha-emitting radionuclides were present. Significant amounts of Pu(239 + 240) were found in the pertechnetate eluted from neutron-activated molybdenum distributed by one manufacturer. The Pu(239 + 240)/Tc-99m activity ratio in the first eluate from these generators varied between 1.3 . 10(-12) and 1.4 . 10(-11). The Pu(239 + 240) contamination is believed to originate from uranium impurities in the molybdenum batch. The build-up of Am-241, the daughter decay product of Pu-241, has also been demonstrated. The estimated Pu-241/Pu(239 + 240) activity ratio at the reference time was 8:1. It is strongly recommended that upper limits for the plutonium content of eluates from nonfission-produced molybdenum should be included in the various pharmacopoeias and that restrictions be placed on the uranium content of molybdenum used for the production of Mo-99 by neutron activation.

Americium↗
PubMed1979

Abnormal whole-body and cellular (erythrocytes) turnover of 22Na+ in normotensive relatives of probands with established essential hypertension.

1. Whole-body elimination rate of 22Na+ was decreased in normotensive or borderline first-degree relatives of hypertensive probands. 2. Whole-body potassium, exchangeable sodium and urine excretion of sodium, potassium and creatinine were similar in relatives and controls. 3. Erythrocyte net influx of 22Na+ was significantly increased in normotensive relatives. 4. Abnormal whole-body and cellular handling of sodium (22Na+) demonstrated in relatives indicates that this abnormality may have an important role in the development of essential hypertension in man.

Erythrocytes↗
PubMed1979

An X-ray fluorescence technique for in vivo determination of lead concentration in a bone matrix.

We have previously reported the in vivo detection of lead in the skeleton of man by means of X-ray fluorescence analysis using a 740 MBq 57Co source for excitation and a 1 cm(3) Ge(Li) detector for registration of the Pb Kalpha and Kbeta radiation. The varying geometry, density and atomic composition of the tissues of interest (mainly fingers) introduce several problems in estimation of the true concentration of a given element. A two-component cylindrical finger phantom was therefore constructed from silica paraffin wax and animal bone ash. The diameter of the finger bone was estimated from X-ray examinations in two orthogonal projections. The bone mineral concentration was then estimated from the quotient of the number of coherent and Compton scattered primary photons. The lead concentration in the finger bones was then derived from a measurement on a finger phantom made of silica paraffin wax and bone ash with the same size and bone mineral concentration as the real bone. The minimum detectable lead concentration in a finger bone was 14 microgram g(-1) for 15 min measuring time. The lead concentration measured in workers from a metal industry was found to be in the range of 40-100 microgram g(-1).

Bone Matrix↗
PubMed1979

Cardiac blood pool imaging--a clinical comparison between red blood cells labeled with 99mTc in vivo and in vitro and 99mTc-labeled human serum albumin.

In 25 patients undergoing radiocardiographic determination of ventricular function, three methods for blood pool imaging were compared. 99mTc was used to label human serum albumin (HSA) and red blood cells (RBC) in vivo or in vitro. The activity concentration of 99mTc in blood was measured during 2 hrs after injection and a significantly higher concentration was found with RBC compared to HSA already after 15 min. The left ventricular to background count rate ratio was significantly lower for HSA after 90 min compared to RBC. There was no statistical difference in 99mTc activity concentration in blood or in left ventricular to background count rate ratio during the two hrs when the two RBC-labeling procedures were compared. 99mTc-labeled RBC are superior to 99mTc-labeled HSA for gated blood pool studies and especially for repeated determinations of ventricular function. Because the in vivo labeling is the most convenient method it has been adopted as the clinical routine at our hospital.

Erythrocytes↗
PubMed1978

Patella alta and gonarthrosis.

The frequency of patella alta as defined by the method of Insall & Salvati in knees with femoro-patellar osteoarthrosis was determined. Patella alta was six times as frequent in knees with osteoarthrosis than in those with a normal femoro-patellar joint. Patella alta is more common in women and is often bilateral.

Female↗
PubMed1978

[Prosthetic fitting in the geriatric leg amputee (author's transl)].

This retrospective study regarding prosthetic fitting in geriatric amputees showed that only about 50 per cent of the patients could be fitted with a prosthesis. The time interval from the amputation until the patients walked adequately with the prostheses was very long. This was due to problems with the healing of the stump, as well as insufficiencies in the medical organization. An increased coordination of the care of these patients before and after an amputation would improve the whole course of events. It is suggested that the main responsibility for these patients should be transferred to physicians, specialized in long-term care medicine.

Age Factors↗
PubMed1977

The reversibility of disuse osteoporosis. Studies of bone density, bone formation, and cell proliferation in bone tissue.

One hind leg of 80 adult rats of the Sprague-Dawley strain was made osteoporotic by immobilization for 9 weeks. Osteoporosis was noted in both the femur and the tibia when the hydrated gross bone density and the bone surface areas were measured. No signs of reversibility were observed during 10 weeks after the period of immobilization. Tetracycline and DCAF labelling failed to show significant signs of increased bone formation during the 10 weeks after remobilization. At the moment of remobilization and for some weeks thereafter, there were signs of depressed mitotic activity in the bone cells when expressed as the 3H-thymidine/DNA ratio. The conclusion was that neither the cell-proliferation rate nor the cellular activity increases sufficiently for restitution of the disuse osteoporosis.

Animals↗
PubMed1976

X-ray fluorescence analysis of lead in human skeleton in vivo.

The lead concentration in the skeleton of living man was measured by X-ray fluorescence analysis. Five former workers from a metal industry were studied. The mean lead concentration in their skeletons was estimated to be 62 mug/g with a standard error of +/- 5 mug/g. A comparison with the "normal" skeletal concentrations of lead in people from southern Sweden showed the skeletal concentrations of the men studied to be about three to nine times higher.

Bone and Bones↗
PubMed1976

Changes in composition and metabolic activity of the skeletal parts of the extremity of the adult rat following immobilisation in a plaster cast.

Immobilisation of the one hind leg in adult male rats was followed by characteristic changes of the bone mass and the percentage composition of the tibia and the femur of the immobilised leg. These changes were studied during an immobilisation period of 1 to 24 weeks. The tibia of the immobilised leg showed significant loss of bone mass expressed as a decrease of its organic and ash weights as compared with the tibia of the non-immobilised leg. There was a significant increase of its percentage water content and significant decrease of its organic and its ash contents. The specific activity of the tibia was increased throughout but the increase was independent of time. The observed changes in bone mass and in percentage composition of the femur of the immobilised leg were almost identical with those of the immobilised tibia. The specific activity of the femur showed a positive almost linear regression. There were observations indicating that the skeletal changes recorded for the tibia were progressive during the period of observation. The changes noted in the femur seemed to be stabilised or even somewhat declining towards the end of the experiment.

Animals↗
PubMed1976

Chemical composition of the skeletal parts of the extremity of the adult rat following below-knee amputation and immobilisation in a plaster cast.

The chemical composition, i.e. ash and calcium contents and organic, hydroxyproline, and hexosamine contents of the acetone-dried diaphyseal cortical bone powder of the tibias and the femurs, was studied in adult rats after a) below-knee amputation and b) immobilisation of the one hind leg in a plaster cast. There were no significant differences in the chemical composition of the chemical composition of the bones of the treated extremity as compared with the corresponding bones from the non-treated control leg, either at different times after the amputation and immobilisation, respectively, or when all obtained values from each bone were tested together. The percentage hydroxyproline content of the tibia was found to be significantly higher than that of the femur in both extremities, both in the amputation and in the immobilisation experiment. The pro mille hexosamine content of the tibia, on the other hand, was significantly lower than that of the femur in both extremeities in the immobilisation experiment.

Amputation, Surgical↗
PubMed1976

Studies on the volume and the activity of the parathyroid glands in osteoporosis of disuse in the adult rat.

Inactivity of the right hind leg was brought about in adult male Sprague-Dawley rats by a) immobilisation in a plaster cast and b) by resection of the sciatic nerve. Determinations of the volume and the activity of the parathyroid glands by morphological methods showed that the parathyroids were, on the whole, not affected by the treatment. Some significant differences observed in some examined parameters should, however, suggest hypofunction of the glands. The serum-calcium level was significantly higher in the treated than in the control rats in the first experiment. No significant differences in serum calcium between treated and control animals were observed in the second experiment. These observations were considered to indicate that the development of localised osteoporosis in these two forms of inactivity did not depend on hyperactivity of the parathyroids. The observed differences in serum-calcium content between the two experiments may suggest that localised osteoporosis in the two cases developed through different pathomechanisms.

Animals↗