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Biomedical subjects

S Mattila

Publications and source records attributed to S Mattila.

At least 163 records · Page 9Linked to original sources

The effects of beta-adrenergic agents on the contractility of transplanted canine heart.

The effects of isoprenaline and adrenalin on the myocardial contractility of transplanted heart were studied in 6 mongrel dogs which had undergone orthotopic cardiac transplantation. Isoprenaline and adrenaline produced a fall in end-diastolic and end-systolic volumes, and an increase in stroke volume, cardiac output and velocity of contraction when the heart rate was increased. Similar changes were observed in 4 mongrel dogs tested as controls, with the exception of a less pronounced increase of cardiac output after administration of isoprenaline and adrenalin and a fall in stroke volume associated with a higher acceleration of heart rate after administration of isoprenaline. These minor differences between the transplanted and intact heart were thought to be a reflexion of the increased blood volume following heart transplantation.

Animals↗

Diaphragmatic pulmonary sequestration.

Two cases of diaphragmatic extralobar pulmonary sequestrations are described. One of them simulated a suprarenal tumour and the other was associated with a diaphragmatic hernia. Both of them were firmly attached to the left hemidiaphragm and were partly located within it. They had an arterial supply from the abdominal aorta. Both sequestrations were treated surgically by sequesterectomy. The patients had an uneventful recovery.

Adolescent↗

Spontaneous mediastinal emphysema: hamman's syndrome.

A case of spontaneous mediastinal emphysema (Hamman's syndrome) is described. The patient was a 21-year-old man, who had a sudden onset of substernal chest pain at rest associated with typical findings of Hamman's syndrome: subcutaneous emphysema of the neck, a precordial crunching sound synchronous with the heart beat and air in the mediastinum on chest x-ray. He recovered uneventfully. The pathogenesis and clinical picture of this rare condition are discussed.

Adult↗

Traumatic rupture of the pericardium with luxation of the heart. Case report and review of the literature.

A report is made of a case of left diaphragmatic and pericardial rupture with luxation of the heart from the pericardial sac, resulting from a steering wheel injury. The patient was successfully treated surgically. In the treatment of this injury, correcting the hemodynamic derangement caused by incarceration and torsion of the heart is stressed. A review of the literature on pericardial ruptures is presented.

Acidosis, Respiratory↗