Biomedical subjects

S Matsui

Publications and source records attributed to S Matsui.

437 records · Page 25Linked to original sources

PubMedDate not supplied

Migration of Gianturco expandable metallic stents in the upper trachea.

Endotracheal expandable metallic stents have been shown to be useful in treating malignant tracheobronchial stenosis. We report two cases of early stent migration in the upper trachea after what appeared to be a successful stent placement. We conclude that care should be taken when placing Gianturco stents across short, extrinsic, stenotic lesions with smooth mucosa located in the upper trachea because they have a tendency to migrate.

Aged↗

PubMedDate not supplied

Helical CT demonstration of dilated right inferior phrenic arteries as extrahepatic collateral arteries of hepatocellular carcinomas.

PURPOSE: The purpose of this work was to demonstrate the appearance of the right inferior phrenic artery (RIPA) on CT in patients with hepatocellular carcinoma (HCC). METHOD: We assessed the biphasic helical CT scans using 10 mm collimation in 16 patients with arteriographically proven HCCs supplied by the RIPAs. Size of the right and left inferior phrenic arteries and origin of the RIPA were evaluated and correlated with arteriographic images. RESULTS: Helical CT showed dilated RIPAs on the right diaphragmatic crus as foci of high attenuation on arterial-phase images in all patients. Diameter of the RIPA (average 3.3 mm) was larger than that of the left inferior phrenic artery (average 1.5 mm). The origin of the RIPAs was correctly predicted in 13 of 16 (celiac artery 6, abdominal aorta 5, right renal artery 2) patients. CONCLUSION: Asymmetric dilatation of the RIPA as an indicator of extrahepatic collateral of HCC can be demonstrated on the right diaphragmatic crus with arteriographic images of biphasic helical CT.

Aged↗

PubMedDate not supplied

CT demonstration of dilated gonadal vein as a portosystemic shunt of mesenteric varices.

PURPOSE: The purpose of this work was to assess CT demonstration of the enlarged gonadal vein as a portosystemic shunt of mesenteric varices. METHOD: The clinical records and CT images of eight patients with angiographically confirmed mesenteric varices were studied retrospectively. We measured the size of the right gonadal vein of these eight patients and also measured the size of the right gonadal vein in 60 patients without mesenteric varices. RESULTS: In all eight patients, CT demonstrated that the mesenteric varices drained into the inferior vena cava through the dilated right gonadal vein (diameter 6-10 mm) in all and that the left gonadal vein was not dilated (diameter 2-3 mm). In 60 patients without mesenteric varices, the diameter of the right gonadal vein was 1-5 mm. CONCLUSION: CT demonstrates the dilated gonadal vein as a portosystemic shunt of the mesenteric varices. Awareness of a dilated gonadal vein in patients with portal hypertension may be helpful to consider the possibility of mesenteric varices.

Adult↗

PubMedDate not supplied

Clinical evaluation of five tumor marker assay in patients with lung cancer.

Five tumor markers (CA19-9, CEA, NSE, SCC, TPA) were measured concomitantly in the serum of 128 patients with primary lung cancer (LC), 148 patients with benign disease (B) and 43 normal volunteers. The positive rates for all the tumor markers were significantly higher in the LC group than in the B group. When multiple tumor markers were quantitated, the specificity for the detection of lung cancer became lower although the sensitivity increased. However, this negative point was made up for to some extent by evaluating the number of positive markers. In monitoring the clinical course, independent changes were observed in markers in some cancer patients. These results implied that measuring multiple tumor markers was of clinical value in monitoring the clinical course of cancer patients as well as in assisting the diagnosis of lung cancer.

Antigens, Neoplasm↗

PubMedDate not supplied

Topoisomerase-I inhibitor SN-38 can induce DNA damage and chromosomal aberrations independent from DNA synthesis.

BACKGROUND: SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11). Generally, topo-I inhibitors stabilize the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage. Therefore, topo-I inhibitors are regarded as S-phase specific. The present study investigated S-phase dependent and independent effects of SN-38. MATERIALS AND METHODS: Effects of exposure of A2780 cells to SN-38 (2 hours) were studied by assessing DNA/protein crosslinks, DNA damage and cytogenetic aberrations. RESULTS: A close correlation (r2 = 0.97) was established between drug-induced DNA/protein crosslinks and double stranded DNA breaks. Cytogenetic analysis revealed near maximum clastogenic effects already evident immediately following 2 hours drug exposure. However, qualitatively, chromatid breaks at 24 hours were different from those at 0 hours, in that at 24 hours they were associated with radial chromosome configurations and sister chromatid exchanges. CONCLUSION: The data corroborate that the S-phase dependent mechanism of action of topo-I inhibitors is also applicable to SN-38. The cytogenetic data indicate two distinct interactions of SN-38 with DNA: immediate induction of chromatid breaks independent from DNA synthesis, and induction of chromatid breaks associated with radial chromosome configurations dependent on DNA synthesis.

Camptothecin↗