To help bolster penile tension mechanically, we have tried implantation of silicone penile prostheses varying in type. Our simple and apparently successful procedures for organic impotence with the implantation of intrapenile silicone prostheses may well deserve recommendation in view of spinal impairment therapeutically categorized irreparable.

Erectile Dysfunction↗

PubMed1975

Antiarrhythmic effect of aprindine on several types of ventricular arrhythmias.

The antiarrhythmic effect of aprindine was compared with those of lidocaine and propranolol on several ventricular arrhythmias-epinephrine arrhythmias in cats, ouabain arrhythmias in cats and guinea pigs, ischemic ventricular arrhythmias in coronary-ligated Beagle dogs. Antiarrhythmic effects of aprindine and lidocaine were observed both in ouagain and ischemic arrhythmias, but not in epinephrine arrhythmias. While propranolol had a strong antiarrhythmic effect against epinephrine and ouabain arrhythmias, it did not increase sinus beats in ischemic arrhythmias. Marked anti-arrhythmic effects of aprindine in ischemic arrhythmias were observed in dogs using either single intravenous administration (4 mg/kg) or intravenous infusion (200 mug/kg/min, 2 mg/kg). Antiarrhythmic activity of aprindine is considered to be about twice as strong as that of lidocaine, but lidocaine is less toxic in experimental animals.

Ajmaline↗

PubMed1975

Impetus to transferring non-motile sperm in the seminiferous tubules into the epididymis.

Effect of intratesticular pressure was examined on non-motile sperms in the testis whether they move toward the epididymis when it is raised. The head portion of the epididymis of the dog was cut apart at the proximal portion to the testis fully exposing the lumen of the epididymis. The electric stimulation of perivascular nerves of the spermatic cord caused spermatozoa to flow out onto the incision site at 5 min. The number of them increased progressively, almost innumerable at 15 min. These results support the view that the elevated intratesticular pressure by electric stimulation surely works to transfer non-motile sperm in the seminiferous tubules into the epididymis.

Animals↗

PubMed1975

FSH, LH and testosterone levels in human seminal plasma.

Testosterone levels in the seminal plasma of 5 normal males, and 30 male sterility patients were measured by radioimmunoassay. In 9 random cases, seminal plasma levels of FSH and LH were determined by radioimmunoassay. The average level of seminal plasma testosterone for the normal males was 72 +/- ng/100 ml, higher than that of the patients: 52 +/- 41 ng/100 ml. The average levels of FSH and LH in the seminal plasma of the 9 random cases were 4.4 +/- 2.0 mIU/ml and 35.4 +/- 5.4 mlU/ml, respectively.

Follicle Stimulating Hormone↗

PubMed1975

Changes in plasma levels of LH, FSH and testosterone following the administration of synthetic luteinizing hormone-releasing hormone to cryptorchid patients.

The levels of LH, FSH and testosterone of three adult groups consisting of normal subjects, unilateral and bilateral cryptorcids were compared before and after LH-RH loading. It was found that both groups of cryptorchid had comparatively high plasma base line levels for both LH and FSH, particularly high in the bilateral group; and both groups responded to LH-RH loading. This indicates that their hypothalamo-hypophyseal systems were probably functioning normally. The plasma base line levels of testosterone were higher in unilateral cryptorchids than in the control group, and lowest in the bilateral cryptorchid group. But the reaction of testosterone levels to LH-RH loading was generally poor in both groups of cryptorchids, suggesting that, in cryptorchid cases, unilateral and bilateral, the capacity of the testicle to secrete testosterone is generally depressed, freeing central suppression. This probably accounts for the high values of plasma lh and FSH observed in such patients.

Adolescent↗

PubMed1975