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Biomedical subjects

S Matsuda

Publications and source records attributed to S Matsuda.

At least 793 records · Page 44Linked to original sources
PubMed1978

Inhibition of platelet function by sulbenicillin and its metabolite.

The effect of sulbenicillin and its major metabolite, alpha-sulfobenzylpenicilloic acid, on platelet function was investigated. Sulbenicillin caused inhibition of platelet aggregation and release reaction in the same manner as carbenicillin. alpha-Sulfobenzylpenicilloic acid was found to cause much stronger inhibition of platelet function. The results indicate that the strong inhibitory action of alpha-sulfobenzylpenicilloic acid may also take part in impaired platelet functions following administration of sulbenicillin to humans.

Blood Platelets↗
PubMed1978

Hepatitis B core particles with endogenous DNA polymerase activity from chimpanzee liver.

Hepatitis B core antigen (HBcAg) particles, approximately 27-28 nm in diameter and rho = 1.30-1.35 g/cm3, were purified from the liver of a chimpanzee experimentally infected with hepatitis B virus (HBV) while under cyclophosphamide treatment. The purified HBcAg particles incorporated radioactive deoxythymidine triphosphate. The product was precipitable by trichloroacetic acid and sensitive to DNase, but resistant to digestion by RNase. The reaction required four deoxyribonucleosise triphosphates- dATP, dCTP, dGTP and dTTP. Exogenous template did not enhance the reaction. From these findings, it was suggested that HBcAg particles purified from the HBV-infected chimpanzee liver contained DNA polymerase and endogenous DNA.

Animals↗
PubMed1978

Antihypertensive effect of trichlormethiazide in spontaneously hypertensive rats.

Antihypertensive and diuretic effects of trichlormethiazide (TCM) were investigated in the spontaneously hypertensive rats (SHR). The antihypertensive effect of TCM in an acute experiment was observed in male SHR only at a dose over 10 mg/kg given intraperitoneally and not in female SHR and normotensive Kyoto Wistar rats. In a subacute experiment (6 weeks), TCM retarded the development of hypertension in the male SHR loaded with 1% saline solution at an oral dose over 1 mg kg-1 day-1 and such had a diuretic effect. Oral administration of TCM and hydrochlorothiazide (HCT) at 10 mg kg-1 day-1 retarded the development of hypertension in the saline loaded female SHR to the same degree, but the relationship between antihypertensive and diuretic effects of both compounds was obscure. Except for decreases of water contents in the thoracic artery and wet weights of hearts, the electrolyte, uric acid, catecholamine and 5-hydroxytryptamine contents in the serum or/and organs were not affected by either TCM or HCT. It is concluded that the antihypertensive effect of TCM and HCT can be observed in SHR with a saline-load, and that the effect may be due to diuretic actions in the male. The relationship was not apparent in female SHR.

Animals↗
PubMed1978

Hemodynamic mechanism of erection in the human penis.

Six infertile patients and one patient with ureteral calculus were studied to elucidate the intrapenial hemodynamics of erection. Xe-133 was infused into the corpus cavernosum and visual sexual stimulation (V.S.S.) provided to induce erection. Xe-133 clearance curves declined at a uniform rate in the nonerect penis without V.S.S. Xe-133 clearance curves for five patients with complete erection at V.S.S. indicated a sudden drop upon erection. Unlike previous reports, it was noted that penial erection can occur independently of a venous-return blocking mechanism.

Adult↗