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S Mason

Publications and source records attributed to S Mason.

107 records · Page 6Linked to original sources
PubMedDate not supplied

The role of alpha1D-adrenoceptors in prostatic contraction examined using protection studies.

1 The aim of the study was to investigate the role of the alpha1D-adrenoceptor in alpha1-adrenoceptor-induced contraction of human prostate by means of protection experiments. 2 Responses of human prostate strips to noradrenaline were recorded, along with responses of rat aorta and vas deferens, tissues possessing predominantly alpha1D- and alpha1A-adrenoceptors respectively, for comparison. alpha1-adrenoceptors were then inactivated by incubation with the irreversible antagonist phenoxybenzamine. In some tissues alpha1A- or alpha1D-adrenoceptors were 'protected' from inactivation by incubation in the presence of the selective alpha1A- or 1D-adrenoceptor antagonists 5-methylurapidil and BMY 7378 before recording further responses to noradrenaline. 3 Phenoxybenzamine reduced the maximum noradrenaline-induced response and the potency of noradrenaline in all tissues. In rat vas deferens and human prostate, 5-methylurapidil protected alpha1A-adrenoceptors in a concentration-dependent manner. In rat aorta, 10 nM BMY 7378 almost fully protected alpha1D-adrenoceptors. However, concentrations of BMY 7378 up to 30-fold higher failed to protect receptors in the human prostate. 4 These results suggest that in human prostate functional alpha1D-adrenoceptors do not contribute to noradrenaline-induced contractile responses.

Adrenergic alpha-1 Receptor Antagonists↗
PubMedDate not supplied

Implementation of an aspect of self-care.

This article describes how a nursing development unit (NDU), through the evolution of a self-care philosophy, responded to the changing needs and demands of patients. Patients in the NDU appeared to want to be more informed and involved in their health care. In addition, decreased length of stay as a result of increased sophistication of medical techniques and the need to have a faster throughput of patients has meant that a philosophy is required which is focused around empowering patients to take ownership for their own health care. The application of this philosophy is demonstrated through a case study which describes the experience of a gentleman who was cared for within the NDU.

Clinical Nursing Research↗
PubMedDate not supplied

The ethical dilemma of the do not resuscitate order.

Tingle (1988) stated that doctors and nurses frequently find themselves in the position of making decisions which are not solely medical or nursing but of a moral or ethical nature. To illustrate this concept the author describes and analyses how the ethical arena has impinged upon her practice. Professional accountability and patient involvement are critical issues which need to be addressed. Do not resuscitate decisions should be based on a collaborative approach centred around the patient.

Attitude of Health Personnel↗
PubMedDate not supplied

Combination therapy with indinavir, ritonavir, and delavirdine and nucleoside reverse transcriptase inhibitors in patients with HIV/AIDS who have failed multiple antiretroviral combinations.

PURPOSE: Ritonavir (RTV) and delavirdine (DLV) are inhibitors of cytochrome P450 (CYP) 3A4, the specific CYP that metabolizes indinavir (IDV). We hypothesized that patients who have failed multiple therapies containing protease inhibitors would still respond to IDV if high plasma concentrations were achieved. We retrospectively examined the antiviral efficacy of the combination of RTV, DLV, and IDV in heavily antiretroviral-experienced patients. METHOD: A chart review of patients treated with IDV/RTV/DLV and two nucleoside reverse transcriptase inhibitor (NRTI) drugs was performed. Only patients who failed at least three highly active antiretroviral therapy (HAART) regimens and remained on IDV/RTV/DLV therapy for at least 2 months were included. Plasma concentrations for IDV and RTV were obtained if patients were still on therapy. RESULTS: Ten participants were identified who qualified for this study. The median plasma HIV RNA prior to initiating IDV/RTV/DLV was 359,300 copies/mL. Nine of the 10 patients had failed nonnucleoside reverse transcriptase inhibitor (NNRTI)-containing regimens in the past. Eight out of 10 patients had at reduction in HIV RNA. Four of eight patients maintained the 1 log(10) reduction in HIV RNA past 6 months. Mean CD4 cell count increased from 142+/-99 to 273+/-126 cells/mm(3). Genotypic data available on six patients showed multiple protease gene mutations. Plasma concentration of IDV in three patients (two troughs and one 7 hours postdose) were >1,000 ng/mL. CONCLUSION: Our data suggests that in heavily antiretroviral drug-treated patients, partial antiretroviral response to RTV/IDV/DLV can still be achieved. The use of IDV/RTV/DLV and two NRTIs as salvage therapy has merit in patients who have no viable treatment options. A prospective trial utilizing this drug combination is warranted.

Adult↗
PubMedDate not supplied

Alzheimer's disease and carers.

This paper is based on the author's impressions of his placement in mental health centres in North Lincolnshire. The focus is on the nature of the relationship between the older person with dementia and those who care for them--nurses and relatives.

Activities of Daily Living↗
PubMedDate not supplied

Custody planning with HIV-affected families: considerations for child welfare workers.

Most of the literature on permanency planning is based on the assumption that HIV-infected parents have custody of their children. A growing number of children entering child protective services, however, have an HIV-infected parent. Whether reunification or adoption is the permanency goal, these parents are concerned about their children's future after the parents' death. This article is drawn from research on custody planning with HIV-infected parents, from clinical literature and experience, and from a training curriculum for child welfare workers developed and implemented by the author. The lessons learned about custody planning with HIV-involved families are applied to practice with families who are involved with the state because of abuse or neglect of their children.

Child↗