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Biomedical subjects

S Martinoli

Publications and source records attributed to S Martinoli.

At least 73 records · Page 4Linked to original sources
PubMed1984

[The effect of proximal-selective vagotomy in gastroduodenal ulcer].

In a recently concluded prospective multicenter trial, pyloric (PU) and prepyloric (PPU) ulcers showed a significantly higher recurrence rate after proximal gastric vagotomy (PGV) without drainage than duodenal (DU) or gastric ulcers (GU). The secretory pattern of the PU and PPU cannot explain the failure of PGV. However, PU and PPU (and some GU) exhibit a distinct and probably irreversible alteration of the muscular layer at the pylorus and distal antrum. This could be one factor which helps to explain the failure of vagotomy alone in these ulcer types. To deal with this antropyloric distrophy, addition of drainage or antrectomy to PGV must be considered. A refined concept for surgical treatment of peptic ulcer is proposed.

Humans↗
PubMed1983

[Surgical treatment possibilities in colonic cancer].

The standard patient with colonic cancer is described. For the last 30 years surgery has been able to cure nearly 50% of colorectal cancers with 5% perioperative mortality. Technical novelties such as the stapler, antibiotics and colon wash have not improved this crude rate. Moderate improvement in cure rates can reasonably be expected from early detection methods. Surgery and endoscopic surgery are complementary and not competitive techniques.

Colectomy↗
PubMed1980

[Long-term results of thoracic truncal vagotomy and pyloroplasty in complicated reflux disease].

In advanced cases of esophagitis with acquired short esophagus and stricture, operative treatment to eliminate gastroesophageal reflux may be difficult or impossible. 24 such patients were treated by transthoracic truncal vagotomy and pyloroplasty. In a long-term follow-up 9--11 years later 12 patients were examined by X-ray and esophagoscopy. In 9 patients symptoms due to reflux or obstruction had improved, 5 of them were symptom-free. At endoscopy and barium-swallow 2 patients showed back-formation of their stricture, the other patients had generally unchanged findings. Transthoracic truncal vagotomy with drainage seems to be able to prevent progression of severe esophagitis and to improve its symptoms.

Esophageal Stenosis↗
PubMed1978

[Pre- and postoperative manometeric findings in the esophagus in proximal selective vagotomy].

15 patients with duodenal ulcer underwent clinical and manometric studies to assess distal esophageal function before and after proximal selective vagotomy. Position, pressure and function of distal esophageal high pressure zone were not altered by the operation. No rationale has been found for the trend to combine proximal selective vagtomy with antireflux procedures.

Duodenal Ulcer↗
PubMed1977

[Proximal selectivive Vagotomie. Intra-operative Vollständigkeitskintrolle].

In the treatment of peptic gastroduodenal ulcers the modified vagomotor electrotest according to Burge has yielded remarkably good results as an intraoperative test for the completeness of proximal selective vagotomy (PSV). The test is as useful for the surgeon in training as for the expert in vagotomy. Moreover the clinical value of the test is demonstrated. If, according to this test, vagotomy is complete, an extreme reduction of gastric acid and a very low rate of relapsing ulcers are seen in our patients. We cannot recommend performing the PSV without this test.

Duodenal Ulcer↗
PubMedDate not supplied

[Initial results with the AO Dynamic Hip Screw (DHS)].

The report is based on a follow-up of over 54 osteosyntheses employing the Dynamic Hip Screw (DHS) of the AO on the proximal femur. The patients, of an average age of 72 years, exhibited the following lesions: fractures of 7 femoral necks, 43 fractures in the pertrochanteric region, 3 reverse fractures and 1 subtrochanteric metastasis. An unstable fracture was present on 26 occasions. The follow-up, carried out personally, was done from 3 to 26 months postoperatively on 38 out of 40 patients still alive. The average age was 68 years. In not a single case was an implant failure or a protrusion of the screw into the joint observed. Technical faults were present in 4 cases (7.4%) that led in 1 case to an infection (1.85%). 37 patients (97%), of which 23 were between 70 and 90 years of age, were able to walk during the follow-up. 34 (89%) of the patients showed symmetrical, or less than 20 degrees of limited hip movement while 12 (32%) sporadically complained of slight pain or weather dependency. 2 of the 7 patients with femoral neck fractures and 4 of the remaining 47 patients with trochanteric fractures (including 1 subtrochanteric metastasis) had to be reoperated. The DHS proved to be a simple and efficient fixation device for proximal femoral fractures in the hands of ten different surgeons. The telescopic sliding of the screw enables a compulsory sintering of the fracture, without leading to penetration of the femoral head or breakage of the implant.

Adult↗
PubMedDate not supplied

Randomized multicenter trial of adjuvant intraportal chemotherapy for colorectal cancer (SAKK 40/81). An interim report.

A prospective, randomized trial of adjuvant portal infusion of 5-fluorouracil in combination with mitomycin C was conducted on 469 patients with operable colorectal cancer. A single postoperative course of the cytotoxic agents was compared with radical surgery alone. The actuarial 5-year survival (median follow-up 48 months) was 70 +/- 3% in the chemotherapy group and 57 +/- 4% in the control group (p = 0.10). The respective figures for disease-free survival were 62 +/- 4% and 53 +/- 4% (p = 0.09). Among the 195 cases with strict adherence to the protocol for adjuvant chemotherapy there were 59 recurrences and 44 deaths in the follow-up period, whereas in the 274 with no or incomplete chemotherapy there were 120 recurrences and 99 deaths (p less than 0.05). Perioperative adjuvant chemotherapy via portal infusion proved to be feasible in a multicenter setting. Follow-up will be continued, in order to provide definitive information on survival according to randomization.

Adenocarcinoma↗