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Biomedical subjects

S Marshall

Publications and source records attributed to S Marshall.

260 records · Page 15Linked to original sources

Morbidity and death due to child abuse in New Zealand.

The purpose of this study was to explore under-diagnosis and racial bias among child abuse morbidity and mortality data from New Zealand. Computerized files of all intentional injury fatalities among children 16 years of age and under for 1978-87, and all hospital discharges for intentionally injured children 16 and under for 1988, were analyzed for evidence of physical abuse and sexual abuse. Among the 92 fatalities, only 21 of 68 deaths due to physical and/or sexual abuse were so coded. In both the mortality and the morbidity data, there was an association between the diagnosis of child abuse and race. In the case of fatalities, Maori and Samoan abuse victims were more likely to be assigned an E-code of E967 ("child battering and other maltreatment") than were "others" (p = 0.04), controlling for sex. In the case of hospitalizations, the association between E967 and whether or not the victim was European was significant for physical abuse only (p = 0.05). Assignment of N-code = 995.5 ("child maltreatment syndrome") as the reason for admission was significantly associated with race for those cases considered by us to have been abused, controlling for age (p = 0.002) or sex (p = 0.004).

Adolescent↗

1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT) and reduced bone mineral density.

The organochlorine pesticide 1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT), is a well-known and widely dispersed "environmental estrogen" (World Health Organization Criteria no. 9; Geneva, Switzerland [1979]). Kelce et al. (Nature, 1995; 375:581-85) recently identified the DDT metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), has also recently been identified as a potent androgen receptor antagonist. The authors examined the relationship between serum levels of DDE and bone mineral density in 68 sedentary women who reported adequate dietary intake of calcium. Reduced bone mineral density was correlated significantly with age (r = -.36, p = .004), as well as with increases in the log of DDE levels in serum (r = -.27, p = .03). The authors also used multiple-regression analysis to examine the influence of other predictor variables on the relationship between log DDE and bone mineral density. The strongest model (p = .002) included log DDE (p = .018), age (p = .002), and years on hormone replacement therapy (p = .10) as predictor variables, and this model afforded prediction of 21% of bone mineral density variation. These results suggest that past community exposures to DDT may be associated with reduced bone mineral density in women.

Absorptiometry, Photon↗

Life experiences among urban adolescents: examining the role of context.

Interest in the influence of context on the psychosocial development of adolescents led to the examination of neighborhood effects on the experience of adolescent life stress. Because of concerns regarding the population and ecological validity of existing measures of adolescent life events, the research group developed a scale for the measurement of life events among urban adolescents based on data from focus group interviews in the community of interest. Investigators utilized three strategies to examine the impact of neighborhood on adolescents' perceptions of life stress in a sample of 114 adolescents (mean age = 15). Results indicated that life stress in the peer domain varied by the adolescent's neighborhood of residence. In addition, family/community stress was linearly related to neighborhood indices of economic resources.

Adolescent↗

The study of CTLA-4 and vitamin D receptor polymorphisms in the Romanian type 1 diabetes population.

Several studies suggested that part of the genetic susceptibility for Type 1 diabetes (T1DM) is encoded by some polymorphisms of CTLA-4 gene (2q33) and of Vitamin D Receptor gene (VDR; 12q12-14). Our aim was to assess their contribution to T1DM genetic susceptibility in the Romanian population. We typed CTLA-4 49 A/G and VDR FokI (F/f), ApaI (A/a) and TaqI (T/t) polymorphisms by Sequence Specific Primer PCR (SSP-PCR) in 204 Romanian diabetic families (756 individuals: 212 T1DM probands and 544 unaffected parents and siblings). We studied alleles transmission using the Transmission Disequilibrium Test (TDT). We found an increased transmission of CTLA-4 49G allele to diabetics (54.8%, p=0.11). The transmission of F (56.1%, p=0.063), a (55.7%, p=0.061) and T (51.8%, p=0.37) alleles of VDR gene to diabetics was increased but did not reach statistical significance. In conclusion we found the same increased transmission of CTLA-4 49 G allele to diabetics as previously reported. VDR FoqI F allele seems to be predisposing while TaqI T allele seems to be protective.

Abatacept↗

Survey of GPs' views of learning disability services.

This survey aimed to examine GPs' awareness of the learning disabilities services in Sandwell, West Midlands, and their attitudes towards them. Sixty-two per cent of GPs participated in the study which involved completion of a short questionnaire or interview. The questionnaire was either administered to the GP during a short interview, or completed by a GP who returned the completed questionnaire to the researcher. Only information obtained in response to the questionnaire has been used in collating the data for this survey. The results show that GPs are very confused about what constitutes a learning disability and have only a limited knowledge of the specialist services available to this client group; furthermore, where they were aware of the services available, accessing them was often problematic. Reasons for these findings, along with recommendations, are discussed.

Community Health Services↗

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Education, Nursing, Diploma Programs↗

State study of pyrotechnics-related injuries and property damage.

In December 1993, the State of North Carolina legalized the sale of certain types of fireworks. To date, no study has examined the impact of legalization of fireworks on health care and public safety. The purpose of this study was to examine the impact of legalized pyrotechnics specific to our state with regard to injury, property damage, and suppression costs. The population groups surveyed were the state fire departments, county fire marshals, hospital emergency departments, and county forest rangers. Each group was asked to complete a questionnaire on all incidents involving pyrotechnics devices, both legal and illegal, used during the study period. A total of 233 responses were received from the 1644 agencies surveyed. Forty-one injuries and 129 fireworks-related fires were reported. Total property loss was $185,570. Property loss, injury costs, and fire suppression costs totaled $799,450. This study provides a very conservative estimate of the problem within our state. Stronger legislation to restrict access to pyrotechnics may reduce the damage and costs they cause.

Blast Injuries↗