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Biomedical subjects

S Mark

Publications and source records attributed to S Mark.

41 records · Page 3Linked to original sources
PubMedDate not supplied

Fourier transform infrared microspectroscopy as a quantitative diagnostic tool for assignment of premalignancy grading in cervical neoplasia.

The early diagnosis and proper identification of cervical squamous intraepithelial lesions plays an important role in a good prognosis for the patient. However, the present practice of screening based on PAP (Papanicolaou) smear and histopathology makes it tedious and prone to human errors. We assess the validity of FTIR microspectroscopy (FTIR-MSP) of biopsies as a method to properly assign the correct stage of premalignancy in patients with symptoms of cervical intraepithelial neoplasia. For the first time we evaluate the biopsies based on the FTIR spectra for different grades of neoplasia in tandem with probabilistic neural networks (PNNs) and histopathology. The results show that the grading of neoplasia based on FTIR-MSP and a PNN differentiates the normal from premalignant with a high level of accuracy. The false positive identification of the normal as cervical intraepithelial neoplasia 1 (CIN1), CIN2, and CIN3 patients is 9.04, 0.01, and 0.01%, respectively. The false negative identification of CIN2 patients as normal and CIN1 patients is 0.01 and 4.4%, respectively. Similarly, the false negative identification of CIN3 patients as normal, CIN1, and CIN2 is 0.14, 6.99, and 9.61%, respectively. The small errors encountered in the grading are comparable to current methods, encouraging advanced studies for the development of mechanized equipment for the diagnosis and grading of premalignant cervical neoplasia.

Algorithms↗
PubMedDate not supplied

[The fat ration for the premature infant].

The authors studied cantitative and calitative fat dietary intake in conditions of isocaloric energetic diets and effects on somatic development and on plasma levels of fats in 3 randomized populations of premature infants. They concluded that dietary intake of 3-6.4 g fats/kg b.w./24 hours permitted a satisfactory somatic development (weight, height, cranial circumference). In conditions of isocaloric energetic diets, levels of fat intake of 3g/kg b.w./24 hours delivered only the energy for proteic syntheses and levels of 5.6-6.4 g/kg b.w./24 hours also permitted the constitution of body deposits. The levels of total lipids and cholesterol were related to the dietary intake of fats. In case of dietary supplementation of linoleic acid, the plasma levels of cholesterol were reduced and the plasma levels of HDL were augmented.

Birth Weight↗
PubMedDate not supplied

Hypercalcaemia in an immobilised patient with pneumonia.

Hypercalcaemia is a serious complication of sepsis and prolonged immobility. Hormonal, humoral and mechanical factors play a complex role in its development. Because hypercalcaemia is associated with a significant increase in morbidity and mortality, early treatment is recommended. Pamidronate is an effective pharmacological agent and should be considered as primary therapy for this syndrome.

Diphosphonates↗