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Biomedical subjects

S Margolis

Publications and source records attributed to S Margolis.

140 records · Page 8Linked to original sources
PubMed1967

Separation and size determination of human serum lipoproteins by agarose gel filtration.

A method is described for the separation of the three major classes of human serum lipoproteins by gel filtration on columns of 4 and 6% agarose gel. After calibration of the columns, the elution volumes of the lipoproteins were used to calculate the molecular sizes and molecular weights of these macromolecules. The technique was employed to demonstrate aggregation of low density lipoprotein following partial delipidation, partial proteolysis, or mild heat denaturation. Agarose gel filtration shows promise as a useful method for the isolation, purification, and characterization of lipoproteins.

Chemical Phenomena↗
PubMedDate not supplied

Automated data entry and retrieval for health-care management.

The development and implementation of a unique system for medical information management are described. An automated, optically scanned data entry system (OpScan) was combined with a generalized, interactive, storage and retrieval system, the Medical Information Management System (MIMS). OpScan-MIMS operates via a time-share system and requires minimal acquisition and maintenance of hardware. The primary advantages of OpScan-MIMS are its efficient and rapid method for data entry, lack of requirement for technical skills, user-generated programs, and cost-effectiveness. OpScan-MIMS has been utilized in a clinic for sexually transmitted diseases for immediate audit of medical records, monitoring of quality-assurance systems, retrieval of data for statistical analysis and clinic management, and as a teaching instrument for medical and paramedical trainees. Further applications to other systems of health-care management are being developed.

Community Health Centers↗
PubMedDate not supplied

The dawn phenomenon, an early morning glucose rise: implications for diabetic intraday blood glucose variation.

Eleven insulin-dependent (type I) diabetic subjects were studied during a 24-h period to assess intraday blood glucose (BG) variation and related free insulin (FI) levels. Ten patients exhibited the dawn phenomenon, a rise in early morning fasting blood glucose (123 +/- 81.1 m/dl; mean +/- SD). This increase was positively and significantly correlated with the morning postprandial BG peak (r = 0.723; P = 0.012). FI/BG ratios were highest during the night (0.717 and 0.666 at 2200 and 0400 h, respectively) and lowest during the early morning (0.294 at 0800 h) (P less than 0.01). Three of the four observed hypoglycemic episodes occurred during the period when free insulin levels were high relative to BG. We conclude that the dawn phenomenon contributed directly and significantly to the BG maximum and indirectly, in some cases, to nocturnal hypoglycemia. It thus played an important role in the intraday blood glucose variation of such patients.

Adolescent↗
PubMedDate not supplied

Public health aspects of Down's syndrome (Mongolism).

Down's syndrome (trisomy 21) which is associated with childbearing in older women has declined in incidence as childbearing in older women has declined. Expectation of life has increased markedly over the same period, leading in turn to a rise in prevalence at older ages. Prenatal diagnosis now makes it technically possible to screen at risk pregnancies. Public health needs to consider the implications of the demographic and obstetric changes.

Down Syndrome↗
PubMedDate not supplied

Primary health care patients' knowledge about diabetes in the United Arab Emirates.

This study defined the baseline level of knowledge about diabetes and the perceived effectiveness of sources of diabetes information in an urban primary health care centre in Al-Ain. A validated questionnaire was administered to 300 randomly chosen adult patients with diabetes. Patient knowledge about diabetes was directly related to their level of general education. Written and electronic media, and contact with a nurse or doctor were effective sources of education on diabetes while "conversation with significant others", dietician or pharmacist were not effective. Nurse- or doctor-centred education appears to be an effective choice for future programmes to provide information to patients with diabetes.

Adult↗