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S Mangione

Publications and source records attributed to S Mangione.

15 recordsLinked to original sources
PubMed1992

[Protective action of 21-aminosteroids in post-ischemic shock (splanchnic artery occlusion). Experimental model].

In anesthetized Wistar female rats a post-ischemic shock have been induced by splanchnic artery occlusion (S.A.O.). In these condition all animals died at 90 min., past release of occlusion and splanchnic reperfusion. 100% of pretreated rats with 21-Aminosteroids (U74389F) at doses of 1.5 mg.kg-1 survive over 3-6 hours, and 50% over 12 hours. Moreover, TNF alpha in these animals decrease significantly (p < 0.05). These results shown that 21-Aminosteroids can cause protective activity on lipoperoxidative damage in post-ischemic shock.

Animals↗
PubMed1992

CompuLung: a multimedia CBL on pulmonary auscultation.

Cardio-pulmonary auscultation, a time honored art, is suffering a declining interest caused by competing diagnostic technology and inadequate training of physicians. Overreliance on diagnostic technology is expensive, not cost-effective and bound to lead to loss of our clinical heritage. We need novel methods to teach and revive this art. Computer-Based Learning (CBL), particularly multimedia supporting graphics plus sound-and-motion pictures, appears to be ideally suited for teaching and sharpening this skill. We present in this paper a multimedia CBL ("CompuLung"), that provides the user with a comprehensive and interactive tutorial on pulmonary auscultation.

Auscultation↗
PubMed1991

A comparison of computer-assisted instruction and small-group teaching of cardiac auscultation to medical students.

Cardiac auscultation is suffering from declining interest, caused by competing diagnostic technology and inadequate training of doctors. Computer-assisted instruction (CAI) supporting graphics and digitized sound could be ideally suited for teaching and sharpening this skill. To evaluate this premise we randomized 35 third-year medical students to 3 hours of seminar teaching plus the use of audiotapes (group 1), the self-use of a MacIntosh-based CAI (group 2), or both (group 3). All students took a pre- and post-test consisting of eight pre-recorded cardiac events and were also assessed for computer anxiety. Although there were no significant differences between pre- and post-tests for each group and among groups, group 1 had a 4.5% deterioration in its diagnostic score compared to the 7.2% and 3.2% improvements of groups 2 and 3 respectively. Group 2 used the CAI significantly more than group 3. We conclude that CAI is at least as effective as seminars in teaching cardiac auscultation to third-year medical students.

Clinical Competence↗
PubMed1991

Erythrocytes prevent inactivation of alpha 1-antitrypsin by cigarette smoke.

Red blood cells (RBC) possess strong antioxidant activity. We tested whether this activity was sufficient to prevent the oxidative inactivation of alpha 1-antitrypsin (alpha 1-AT) by cigarette smoke. We found that RBC in physiological concentrations completely prevented the inactivation of alpha 1-AT. The major erythrocytic antioxidants, catalase, superoxide dismutase and glutathione were then selectively inhibited and the RBC retested. Only the inhibition of catalase significantly impaired the protective ability of added erythrocytes. We suggest that RBC antioxidants may be an important variable in determining the degree of protection of alpha 1-AT against oxidation.

Catalase↗