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Biomedical subjects

S Maki

Publications and source records attributed to S Maki.

At least 163 records · Page 9Linked to original sources
PubMed1982

Hemodynamic effects of prostaglandin E1 during cardiopulmonary bypass in infants and children.

Effects of prostaglandin E1 (PGE1) and phenoxybenzamine (POB) on the hemodynamics during cardiopulmonary bypass (CPB) were studied in 30 infants and children. Patients were grouped into three; PGE1 was given to ten patients, POB to another ten, and the other ten patients served as the control. Vasodilating drugs were withheld. PGE1 was infused at 0.01 to 0.02 microgram/kg/min during CPB, and POB at 1.0 mg/kg within the initial 10 minutes of bypass. There was a significant drop in arterial and venous pressure at the time of initiation of bypass in both the PGE1 and POB groups. In the PGE1 group in particular, such a stable hemodynamic condition of over 60 mm Hg in mean arterial pressure, 7.5 to 12.5 cmH2O in central venous pressure, 1300 to 1700 dynes . sec . cm -5 in systemic vascular resistance was maintained throughout CPB, as compared with the other two groups. PGE1 contributed to an adequate diuresis and the preservation of platelets. Our findings indicate that PGE1 has potential clinical advantages for application during CPB.

Alprostadil↗
PubMed1982

Urinary fibrinogen and fibrin fragments in children with renal disease.

Fibrinogen fragments (X, Y, D and E) and fibrin fragments (D-dimer and E) were examined in the urine of 52 patients with various types of renal diseases. One or more of the fibrinogen fragments were detectable in all the urine specimens. D-Dimer together with fibrinogen fragments was found in 38 of the 52 patients. The clearance ratio of D-dimer to IgG, which indicates D-dimer generated in the kidney, was lower than 1 in all the patients with the minimal changes nephrotic syndrome, and was greater than 1 in the majority of patients with acute glomerulonephritis, rapidly progressive glomerulonephritis, mesangial proliferative glomerulonephritis and membranoproliferative glomerulonephritis. Our results suggest that urinary fibrin/fibrinogen degradation products (FDP) in renal diseases are derived primarily from increased filtration of FDP from the plasma through a damaged glomerular basement membrane, and that the mechanism of lysis of cross-linked fibrin deposited in the glomeruli occurs simultaneously in some types of glomerulonephritis. It seems that the determination of the clearance ratio of D-dimer to IgG may be useful in assessing the activation of the coagulation and fibrinolysis systems in the kidney in patients with renal diseases.

Adolescent↗
PubMed1982

Heterophile Hanganutziu-Deicher antibodies in sera of patients with Kawasaki diseases.

The heterophile antibody levels in sera from patients with Kawasaki disease (49 sera from 39 cases) were measured by sheep erythrocytes (SRBC) agglutination and radioimmunoassay in microplates coated with Hanganutziu-Deicher (H-D) antigen-active glycosphingolipid, equine hematoside. The antibody levels were low in the first week of illness, increased rapidly in the 2nd week, and thereafter gradually decreased. The SRBC agglutination titers and H-D antibody titers of sera from patients with Kawasaki disease from week 2 to 8 of illness were significantly higher than those of healthy children (44 sera) and normal cord blood (13 sera).

Antibodies, Heterophile↗
PubMed1981

Transient remission of juvenile rheumatoid arthritis after measles.

A 4-year-old Japanese girl with systemic juvenile rheumatoid arthritis had an attack of measles. On the day following the first signs of measles she became afebrile and free of joint pain even though aspirin therapy was discontinued. The remission lasted for 10 days. It appears that the measles virus infection may have been responsible for the brief remission in this patient. The observation of a remission of juvenile rheumatoid arthritis after measles is extremely rare.

Arthritis, Juvenile↗
PubMed1981

Plasma factor XIII levels in children with renal disease.

Plasma levels of coagulation factor XIII determined quantitatively were found to have a tendency to be decreased in more severely affected cases of acute poststreptococcal glomerulonephritis and Henoch-Schönlein nephritis, and found to be decreased in patients with rapidly progressive glomerulonephritis and chronic renal failure in comparison with normal controls. It seems that the degree of decrease in factor XIII reflects the intensity of glomerular damage. In contrast, the patients with the nephrotic syndrome showed significant elevation of plasma factor XIII levels and it was closely correlated with the increase in serum triglycerides. The elevation of factor XIII levels in the nephrotic syndrome is suggested to be mainly attributed to enhanced protein synthesis in connection with urinary loss of proteins.

Adolescent↗
PubMed1980

Safe limit of hemodilution in cardiopulmonary bypass -comparative analysis between cyanotic and acyanotic congenital heart disease.

A safe limit of hemodilution in cardiopulmonary bypass (CPB) for open heart surgery was investigated by analyzing of the perfusion results of 100 patients with tetralogy of Fallot (TOF) and ventricular septal defect (VSD). The higher perfusion flow was necessary to compensate for the reduced oxygen carrying capacity and to maintain adequate arterial pressure in proportion to the increase in hemodilution. Once the dilution ratio reached over 40% in TOF and 50% in VSD, however, adequate oxygen transfer and stable hemodynamic conditions could not be maintained. The former was due to inadequate oxygen delivery and the latter to an impaired venous return. In these cases, various complications caused by residual diluent in the body space despite of extensive diuretic therapy occurred immediately postop. The safe limit of hemodilution is 50%. However, that of cyanotic disease, even in the presence of remarkable polycythemia, must be limited to less than 40%.

Cardiopulmonary Bypass↗
PubMed1980

Combined use of phenoxybenzamine and dopamine for low cardiac output syndrome in children at withdrawal from cardiopulmonary bypass.

The combined use of phenoxybenzamine and dopamine was applied in infants and children when it was difficult to come off cardiopulmonary bypass for low cardiac output. The rationale of this method is to prevent the alpha-adrenergic action of dopamine by phenoxybenzamine and to encourage the beta-adrenergic and direct specific action of dopamine. Dopamine was used in dosage of 10 to 30 micrograms/kg per min after the additional administration of a half of the initial dosage of phenoxybenzamine; this was infused by drip always in a dosage of 0.5 to 1.0 mg/kg during the first half of cardiopulmonary bypass. It was possible to come off cardiopulmonary bypass with a stable haemodynamic state (mean arterial pressure more than 60 mmHg and total peripheral vascular resistance less than 2000 bynes s cm-5) and a good urinary output.

Cardiac Output, Low↗
PubMed1978

Complications of trochanteric osteotomy in total hip replacement.

Nearly 5 per cent of 728 hips showed separation and migration of the trochanteric fragment after total hip replacement using the transtrochanteric approach and a cruciate two-wire technique of reattachment. In the 728 consecutive hips, thirty-five trochanters showed separation and eighteen patients had a positive Trendelenburg test. The abductor weakness was correlated with the amount of separation especially if it exceeded two centimeters. Trochanteric separation was attributed to osteoporosis or poor technique in all but two hips, and trauma was implicated in one.

Arthroplasty↗