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Biomedical subjects

S Magoun

Publications and source records attributed to S Magoun.

At least 37 records · Page 2Linked to original sources
PubMed1995

Morphine-augmented cholescintigraphy enhances duodenogastric reflux.

Morphine intervention in cholescintigraphy decreases imaging time to diagnose acute cholecystitis. Not infrequently we observe duodenogastric reflux during scintigraphy with and without morphine intervention. To evaluate occurrence of duodenogastric reflux related to morphine, we reviewed 55 patients who underwent cholescintigraphy with (32) and without (23) morphine intervention. Morphine was injected when there was bowel activity with non-visualization of the gallbladder at 60 min. Duodenogastric reflux was identified by the appearance of activity in the area just below or immediately adjacent to the tip of the left hepatic lobe laterally. Among 32 patients with morphine intervention, 19 had acute cholecystitis and 13 chronic cholecystitis. Eleven of 19 (58%) with acute cholecystitis had duodenogastric reflux and 6 of 13 (46%) had duodenogastric reflux in chronic cholecystitis. The total of duodenogastric reflux in the group with morphine injection was 53%. Two patients' duodenogastric reflux occurred before morphine injection and was more apparent after morphine was given. In the without morphine group, 3 had acute cholecystitis and 20 had chronic cholecystitis; 2 (one acute and one chronic cholecystitis) of these 23 (9%) had duodenogastric reflux. Our results indicate: (1) occurrence of DG reflux in morphine augmented cholescintigraphy is not significantly different in cholecystitis from that in chronic cholecystitis; (2) duodenogastric reflux in morphine augmentation occurs significantly more often than without morphine intervention (p < 0.001). We conclude that cholescintigraphy with morphine enhances duodenogastric reflux. The degree of duodenogastric reflux in the acute cholecystitis patients has been more severe than in the chronic cholecystitis patients.

Acute Disease↗
PubMed1994

Demonstrable photopenic lesion in Tc-99m pertechnetate thyroid imaging after recent contrast radiographic procedure.

Iodine-contained contrast media of a recent arteriogram can block normal thyroid uptake of Tc-99m pertechnetate or radioiodine, resulting in virtual nonvisualization of the thyroid gland and showing a prominent salivary activity. In Tc-99m pertechnetate thyroid imaging, however, diffuse soft-tissue uptake in the anterior neck surrounding a fluid containing (cystic) lesion may standout as photopenia. The authors present two patients with recent contrast radiographic procedures who underwent Tc-99m pertechnetate imagings that demonstrated photopenic lesions: one was a thyroid cyst and the other confirmed an abscess.

Abscess↗
PubMed1993

Surface and volume three-dimensional displays of Tc-99m HMPAO brain SPECT images in stroke patients by a three-headed gamma camera.

Twenty patients with strokes were studied to evaluate volume and surface three-dimensional (3D) displays in Tc-99m HMPAO brain SPECT imaging using a triple-head gamma camera interfaced with a 64-bit super computer. In each patient, after an intravenous injection of 20 to 30 mCi of Tc-99m HMPAO, a first-pass cerebral flow study and brain SPECT images at 30 to 60 minutes were obtained. Although the cerebral lesion was more clearly delineated with surface 3D and volume 3D, crossed cerebellar diaschisis in seven patients was more clearly exhibited by volume 3D rather than surface 3D imaging. Volume and surface 3D displays enhance continuity of structures and understanding of spatial relationships; these displays view the brain from all angles, and thus the location and extension of lesion(s) in the brain are much easier to appreciate. It is concluded that 1) both surface and volume 3D displays equally enhance SPECT interpretation; and 2) volume 3D display enhances demonstration of crossed cerebellar diaschisis, but surface 3D display does not.

Brain↗
PubMed1993

Extracardiac 'hot' and 'cold' areas on thallium-201 myocardial SPECT imaging.

A 72-year-old man underwent Persantine 201Tl myocardial SPECT imaging that showed a transient area of extracardiac radiotracer accumulation inferior to the inferior wall of the left cardiac ventricle, and a persistent, rounded, cold area in the liver. CT of the abdomen confirmed a cystic lesion in the liver corresponding to the cold area, and the transient extracardiac tracer accumulation area corresponded to a large aneurysm of the distal descending thoracic aorta. An extracardiac abnormal area of 201Tl localization, 'hot' or 'cold', should be included for scan interpretation to depict thoracic and/or upper abdominal lesions(s).

Aged↗
PubMed1993

Bile leak from gallbladder perforation mimicking bowel activity and a false-negative result in a morphine-augmented cholescintigraphy.

Cholescintigraphy of a patient with bile leak demonstrated intra-abdominal activity that mimicked normal bowel activity. Because the gallbladder was not visualized, morphine was injected intravenously. Gallbladder activity after morphine injection was misleading in the finding of chronic cholecystitis. Concurrent abdominal sonography and computerized tomography revealed a thickened gallbladder wall with a gallstone and pericholecystic fluid collection. Exploratory laparotomy confirmed acute and chronic cholecystitis, cholelithiasis, choledocholithiasis, and a pericholecystic abscess. The false-negative conclusion for acute cholecystitis in the patient's morphine-augmented cholescintigraphy resulted from an acceleration of bile leakage due to pre-existing gallbladder perforation.

Aged↗
PubMed1992

Prostate adenocarcinoma using Gleason scores correlates with prostate-specific antigen and prostate acid phosphatase measurements.

To evaluate a relationship between Gleason scores of histopathology of prostate carcinoma and concurrent serum prostate-specific antigen (PSA) and prostate acid phosphatase (PAP) values, 65 men with prostate carcinoma were studied. These patients' cumulative Gleason scores were obtained by totaling the primary and secondary patterns, resulting in two groups: 42 patients received high (6-10) and 23 received low (2-5) Gleason scores. Serum PSA and PAP values were measured by radioimmunometric assay 1 to 7 days before surgical procedures or biopsy for prostate carcinoma. Mean serum PSA for patients in the high Gleason score group was 134.39 ng/mL (normal range: 0 to 4), and the mean serum PSA for patients in the low Gleason score group was 23.62 ng/mL. Mean serum PAP for patients with high scores was 28.08 ng/mL (normal range: 0 to 5), and the mean serum PAP for patients with low scores was 18.19 ng/mL. Patients with high Gleason scores showed significantly greater elevation of serum PSA than those with low Gleason scores (P = .047), using two samples to test for groups having unequal variants. Prostate acid phosphatase levels of patients with high scores were not significantly higher than the levels in patients with low scores (P = .60). These results indicate that PSA levels but not PAP levels correlate with Gleason scores.

Acid Phosphatase↗
PubMed1990

I-123 HIPDM planar brain images demonstrating crossed cerebellar diaschisis.

I-123 HIPDM or IMP brain planar images, as well as SPECT images, have been useful in the detection of large lesion(s) of the cerebral cortex. Planar imaging may be useful not only for cerebral lesions, but also for a cerebellar abnormality and in certain clinical situations, such as phobia to a gantry or being too heavy for the imaging table, when SPECT imaging cannot be performed. The authors concur that a large cerebral lesion can be detected by planar images; in addition, cerebellar lesions, such as the presence of crossed cerebellar diaschisis (CCD), may be detectable by planar imaging using I-123 HIPDM. This article presents a patient with a large cerebral infarct detected by planar imaging whose CCD has been demonstrated by planar images.

Aged↗
PubMed1990

Serum osteocalcin measurements in prostate carcinoma patients with skeletal deposits shown by bone scintigram: comparison with serum PSA/PAP measurements.

The correlation of technetium-99m-HMDP bone scintigraphic findings, serum osteocalcin as a measure of bone turnover and prostate-specific antigen (PSA) and/or prostate acid phosphatase (PAP) was determined in 19 men with bone metastasis due to prostatic carcinoma. Six of the 19 patients with metastases on bone scan showed elevation of osteocalcin. These patients had extensive metastatic disease. All 19 men with positive bone scans had high serum PSA and/or PAP levels. Serum osteocalcin measurement is less sensitive to detection of bone deposits than PSA/PAP measurements (p less than 0.0008).

Acid Phosphatase↗
PubMed1989

Correlation of prostate-specific antigen and technetium-99m HMDP bone imaging.

For an evaluation of the clinical utility of prostate-specific antigen (PSA), 32 prostatic carcinoma patients (ages 54-76) and 13 nonprostatic carcinoma patients (ages 60-70) underwent PSA measurements and bone imaging. At the time of bone imaging, each patient's PSA value was measured by a monoclonal immunoradiometric assay. All 13 nonprostatic carcinoma patients (11 bronchogenic, 1 colon, and 1 urinary bladder) gave normal PSA values, although 6 had metastatic bone disease. The 32 prostatic cancer patients were divided into 2 groups of 16 each; PSA levels in Group 1 were abnormal (greater than or equal to ng/ml): PSA levels in Group 2 were normal (less than 4 ng/ml). In Group 1, bone images of 14 patients showed bone metastases; 6 of the 14 showed progression of metastases in a 6- to 12-month period. Two patients in Group 1 were negative for skeletal metastases. Twelve patients in Group 2 were negative for skeletal metastases; bone imaging in 1 showed regression of skeletal metastases; and 3 patients had unchanged bone lesion(s). The data indicate that PSA measurements may enhance bone imaging interpretation and provide valuable clinical monitoring of prostatic carcinoma. In the case of a patient with positive bone imaging and an unknown primary, PSA measurements may definitively determine if metastases originated from prostatic carcinoma.

Aged↗
PubMed1988

Intense bone imaging agent uptake in the soft tissues of the lower legs and feet relating to ischemia and cold exposure.

We present a patient with diffuse and intense uptake in the soft tissues of both lower legs and feet seen on 99mTc-HMDP bone scintigraphy. This finding presumably resulted from compromised blood supply to the lower legs plus a cold environment. The extraosseous bone imaging agent localization was presumably related to an existing ischemic condition that was exacerbated by cold. Differential diagnosis of the scan pattern should be differentiated from the artifact of socks contaminated by radioactive urine.

Aged↗
PubMed1988

Paget's disease mimicing skeletal metastases in a patient with coexisting prostatic carcinoma.

We present a 93-year-old man with prostatic carcinoma whose 99mTc-HMDP skeletal images showed multiple areas of abnormally increased radioactivity in the bone and virtual absence of renal activity. These findings were interpreted as representing multiple skeletal metastases. When correlated with concurrent radiographs, the abnormalities were found to be due to Paget's disease. Multiple areas of bone involvement are not rare in Paget's disease. We reemphasize that an abnormal bone scintigram should always be correlated with regional radiographs to rule out conditions other than malignancy.

Aged↗
PubMed1988

Malunion of a femoral fracture mimicking osteomyelitis in three phase bone imaging.

A case of greatly increased blood flow in the region of a fracture with malunion of the left femur, both in the flow and immediate blood pool studies during three phase bone imaging, is presented. The sluggish left femoral artery flow resulted from the greatly increased regional perfusion and is similar to the findings in acute osteomyelitis. The sluggish left femoral artery flow and greatly increased regional perfusion of the site is probably best explained as a regional "neurovascular flush" resulting from the pain caused by the malunion of the fracture and/or hyperemia in the area of the malunion responding to inflammation.

Aged↗