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Biomedical subjects

S Maglajlić

Publications and source records attributed to S Maglajlić.

3 recordsLinked to original sources

[Multicystic dysplastic kidney. Therapeutic dilemmas and personal experience].

A multicystic dysplastic kidney (MCDK) is one of the most frequent causes of abdominal mass in the neonate. Prenatal echography permits early and frequent diagnostics. It is a nonfamilial disease without associated cystic disease of the pancreas, liver or lungs. Indications for elective surgery are clear when there is a symptomatic disease. However, treatment of asymptomatic patients is controversial. A rising number of authors prefer nonsurgical approach, leaving MCDK intact with a close follow-up of patients for possible severe complications (malignancy, hypertension, infection, pain, rupture). We treated 15 patients with MCDK from 1984 to 1994. Diagnosis was passed antenatally in 7 (47%) patients, accidentally in 2, and based on the presence of abdominal mass in 6 patients. Two patients had renal failure due to the abnormal contralateral kidney. Nine patients were operated on and 6 were treated nonsurgically. The risk of complications associated with nonsurgical treatment, easiness of efficient surgery at the age of 3-6 months, avoiding stress in the child and family due to long-term follow-up, all suggest operative treatment. We suggest to parents both operative and nonoperative options, explaining the risk and danger of both. We believe that nephrectomy is the best solution in a child with MCDK who is growing, develops hypertension, with uncertain diagnosis or when adequate follow-up is impossible.

Female↗

[The Crigler-Najjar syndrome, type I. Therapeutic dilemmas].

Crigler-Najjar syndrome type I is a rare hereditary disease that is manifested by high concentration of unconjugated bilirubin in serum, which may lead to neurologic disorders. Management consists of conservative therapy and partial liver transplantation and, since recently, hepatocyte transplantation. Both therapeutic procedures have been continually improved and are yielding better results. We present a girl, aged three and a half years, who has been living at the Neonatology Department of the University Childrens Hospital in Belgrade since birth due to the permanent need for phototherapy and other measures so as to keep her bilirubin at minimal level. We present numerous management dilemmas, having in mind the controversial attitudes of physicians from other world centres, starting from those who consider that surgery should be done before the age of six years to those who consider that the patient should be treated conservatively only. Our attempts to avoid neurological disorders developing in our little patient surpasses professional interest only, because this girl is an exceptionally lovely and smart child with IQ 128.

Child, Preschool↗