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Biomedical subjects

S Müller-Lissner

Publications and source records attributed to S Müller-Lissner.

At least 19 recordsLinked to original sources
PubMed1992

[Side effects of laxatives].

The side effects of anthraquinones, diphenylmethane derivatives (e.g. bisacodyl, sodium picosulphate), saline laxatives, lactulose, and cisapride are discussed. When taken in recommended doses, no relevant side effects have been observed, except for hypermagnesemia following magnesium containing cathartics in renal insufficiency. This holds also true for the time of pregnancy and lactation. (Pseudo-)melanosis coli is characterized by pigment loaded macrophages without apparent functional consequences. It occurs mainly after anthraquinones, but to a lesser degree also after diphenylmethane derivatives. Clinically relevant side effects of the above laxatives have been published exclusively after excessive dosing. They consist in electrolyte disturbances (mainly hypokalemia), metabolic alkalosis, renal tubular dysfunction, and other less frequent side effects. Cases of "cathartic colon" have not been published during the last decades. It was probably due to laxatives which are no longer used.

Acid-Base Equilibrium↗
PubMed1991

[Interaction of motility and secretion of the stomach--pathophysiologic aspects].

The pathophysiologically most important disturbances in gastrooesophageal reflux disease are inappropriate relaxations and decreased basal pressure of the lower oesophageal sphincter. Slowed gastric emptying probably is an additional factor which may increase the likelihood of reflux. Changes in gastric secretion are of minor importance. In duodenal ulcer, the feedback inhibition of gastric emptying which is normally seen when acid is perfused in the duodenum is disturbed. Hence the duodenal bulb is exposed for a longer time to a low pH. Gastric vagatomy leads not only to decreased gastric secretion but also to quicker gastric emptying, in particular when a drainage procedure is performed concomitantly.

Duodenal Ulcer↗
PubMed1989

[Disorders of stomach emptying].

During the course of viral infections, acute delays in gastric emptying are common. Usually, dietary measures suffice, but treatment with dopamine antagonists with their additional antiemetic effect, may be beneficial. The major causes of chronic delayed emptying are diabetes mellitus with autonomic neuropathy, connective tissue diseases such as systemic sclerosis, and gastroparesis following gastric surgery. Diet alone is rarely effective, and prokinetic drugs should be prescribed. The new compound cisapride seems to be particularly effective. Abnormally rapid emptying occurs exclusively following surgical destruction of the gastric outlet and may lead to the dumping syndrome. In general this can be adequately controlled by dietary measures.

Diagnosis, Differential↗