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Biomedical subjects

S M Robinson

Publications and source records attributed to S M Robinson.

At least 91 records · Page 5Linked to original sources
PubMed1977

Prediction for secondary structures of ten proteins from the 50S subunit of the Escherichia coli ribosome.

Predictions of the secondary structures of the following 10 proteins from the large subunit of the E. coli ribosome were made using their known amino acid sequences: L6, L16, L19, L27, L28, L30, L31, L32, L33, and L34. The predictions were made according to 4 different methods and the results for each protein are presented as diagrams indicating the conformational states, helix, extended structure, turn, and random coil, of each residue. From these diagrams, regions of highly probable secondary structure for the proteins are calculated. Estimates are made of the maximum possible lengths of the proteins in order to correlate these with the results obtained from antibody binding sites in the 50S subunit as determined by electron microscopy.

Amino Acid Sequence↗
PubMed1977

Secondary structures of proteins from the 30S subunit of the Escherichia coli ribosome.

The secondary structures of the proteins S4, S6, S8, S9, S12, S13, S15, S16, S18, S20 and S21 from the subunit of the E. coli ribosome were predicted according to four different methods. From the resultant diagrams indicating regions of helix, turn, extended structure and random coil, average values for the respective secondary structures could be calculated for each protein. Using the known relative distances for residues in the helical, turn and sheet or allowed random conformations, estimates are made of the maximum possible lengths of the proteins in order to correlate these with results obtained from antibody binding studies to the 30S subunit as determined by electron microscopy. The influence of amino acid changes on the predicted secondary structures of proteins from a few selected mutants was studied. The altered residues tend to be structurally conservative or to induce only minimal local changes.

Alleles↗
PubMed1976

Amelioration of the symptoms of acute mountain sickness by staging and acetazolamide.

Treatment by 4 d of residence at 1600 m plus the administration of 500 mg acetazolamide b.i.d. for the last 2 d at 1600 m and the first 2 d at 4300 m was compared with no treatment prior to ascent to 4300 m for prophylaxis of acute mountain sickness. The treatment successfully prevented almost all symptoms of acute mountain sickness. It had no effect on the diminished capacity for maximal or prolonged heavy physical work. The treatment produced a relative acidosis and a comparatively greater arterial oxygen tension at 4300 m.

Acclimatization↗
PubMed1975

2-Deoxy-D-glucose inhibition of prostaglandin E1 hyperthermia and yeast fever in mice.

2-Deoxy-D-glucose (2-DG) and sodium salicylate were evaluated relative to their effects on body temperature in mice with prostaglandin E1 (PGE1)hyperthermia or yeast fever. Injection of 2-DG into the cerebral ventricles of conscious mice abolished the hyperthermia of PGE1 and reduced the fever produced by yeast, while sodium salicylate was effective only in yeast fever. The data are suggestive of glucose dependency of thermoregulatory centers in the brain.

Animals↗