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Biomedical subjects

S M Podos

Publications and source records attributed to S M Podos.

209 records · Page 12Linked to original sources
PubMedDate not supplied

Epinephrine as the initial therapy in selected cases of ocular hypertension.

The authors believe that the epinephrines should be employed as the initial therapy in both primary open angle glaucoma and, when treated, ocular hypertension. Unlike pilocarpine, epinephrine does not produce miosis and accommodative spasm. Because of longer experience with epinephrine than with costly timolol, its longterm effectiveness and side effects are better known. Although the side effects of epinephrine are usually not serious, they may be intolerable to the patient. However, allergic blepharoconjunctivitis may be ameliorated by concomitant hydroxymesterone therapy. The availability of dipivalyl epinephrine (DPE) may decidedly shift the balance of the treatment of ocular hypertension, when indicated, to an epinephrine compound.

Costs and Cost Analysis↗
PubMedDate not supplied

A comparative study of latanoprost (Xalatan) and isopropyl unoprostone (Rescula) in normal and glaucomatous monkey eyes.

Latanoprost (PhXA41, Xalatan) and isopropyl unoprostone (UF-021, unoprostone, Rescula) two new prostanoid derivatives, have been shown to reduce intraocular pressure (IOP) significantly in patients with glaucoma or ocular hypertension. This study was designed to compare the ocular hypotensive effects of latanoprost and unoprostone in cynomologus monkeys with glaucoma and characterizes the prostanoid's mechanisms of action in normal cynomolgus monkey eyes. Intraocular pressure was measured daily at 0, 0.5, and 1 hour and hourly for 5 additional hours during 1 baseline day, 1 vehicle-treated day, and 5 days of therapy with either 0.005% latanoprost or 0.12% unoprostone applied twice daily, at 9:30 AM and 3:30 PM, to the glaucomatous eye of eight monkeys with unilateral laser-induced glaucoma. Outflow facility was measured in six normal monkeys 3 hours prior to dosing and 1 hour after unilateral dosing with either drug. Aqueous humor flow rates were measured in six normal monkeys hourly for 4 hours on 1 baseline day and on 1 treatment day beginning 1 hour after administration of either drug to one eye. Intraocular pressure was significantly (P < 0.005) reduced after the first application for 4 hours with latanoprost and for 2 hours with unoprostone, up to 5.4 +/- 0.8 mm Hg (mean +/- SEM) (latanoprost) and 3.8 +/- 0.5 mm Hg (unoprostone). Intraocular pressure was significantly (P < 0.005) reduced for at least 18 hours following each PM dose of latanoprost. Intraocular pressure was not reduced (P > .05) 18 hours after each PM dose of unoprostone. An enhancement of the ocular hypotensive effect was observed from day 1 to day 5 with repeated dosing of either drug. Latanoprost produced a greater magnitude of IOP reduction for a longer duration of time than unoprostone after each application. Neither drug altered outflow facility or aqueous humor flow rates. Latanoprost and unoprostone appear to reduce IOP in monkeys by enhancing uveoscleral outflow. Latanoprost appears to be more efficacious and potent than unoprostone in reducing IOP in glaucomatous monkey eyes.

Administration, Topical↗
PubMedDate not supplied

Visual field progression in open-angle glaucoma patients presenting with monocular field loss.

Twenty-one patients with primary open-angle glaucoma were followed an average of 4.4 years after developing monocular field loss. Nine of the undamaged fellow eyes developed field loss, while 16 of the 21 eyes presenting with field loss showed progression of field changes. In 13 patients, the presenting eye had a greater progression of field loss than the fellow eye, and asymmetry of pressure control explained this in only five patients. Eleven patients with symmetric pressure control had progressive field changes in one or both eyes, and in seven, the presenting eye showed greater progression than its fellow. This suggests that an eye with field loss may be more susceptible to progression of field changes at similar pressure levels than an eye without previous damage. Furthermore, patients with unilateral field loss have a greater incidence of field loss in the undamaged fellow eye than do patients with bilateral ocular hypertension.

Adult↗