Biomedical subjects

S M Peters

Publications and source records attributed to S M Peters.

23 records · Page 2Linked to original sources

PubMed1983

Extracorporeal immunomodulation (EIM) by plasmaleukapheresis (PLP) in the treatment of steroid resistant renal rejection.

We report the use of plasmaleukapheresis (PLP) to treat renal allograft rejection which had failed to respond to conventional pulse corticosteroid therapy. Twenty-three patients who failed to respond to at least 3 boluses of IV methylprednisolone received PLP. Sixteen of these patients had either complete (12) or partial (4) response to PLP. In the responding group, the mean serum creatinine was 1.5 +/- 0.3 mg/dl. In the partially responding group, the mean serum creatinine was 3.9 +/- 0.3 mg/dl. Plasmaleukapheresis resulted in the reduction in levels of circulating immune complexes (CIC), and T and B cells. Circulating null cell levels increased. All 5 patients with low (less than 10%) pretransplant cytotoxic antibody levels had complete response to plasmaleukapheresis. We conclude that PLP, perhaps by removal of CIC, antibody and/or population of circulating T or B cells, may be capable of reversing steroid resistant rejection, especially in patients with low levels of pretransplant cytotoxic antibodies.

Adult↗

PubMed1983

Immunologic studies of human schistosomiasis. I. Clinical and immunological findings in acute and chronic schistosomiasis.

Sera and ascitic fluid of 26 patients with acute and chronic schistosomiasis were studied for the presence of circulating immune complexes (CIC's), IgG, IgM, IgA, complement C3 and C4, as well as their correlation with the clinical manifestations of the disease. Serum levels of CIC's and IgG were significantly increased in patients with acute S. mansoni and S. haematobium infections and in patients with chronic schistosomiasis. Serum IgA levels were evaluated in 20% of patients with S. mansoni infection, 67% with S. haematobium infections and in 100% of chronically infected patients. Complement C3 levels were normal in all patients. Ascitic fluid analysis revealed the presence of IgG, IgM, IgA, C3 and C4 and high concentrations of CIC's. A significant positive correlation was demonstrated to occur between serum CIC's and IgG, as well as between the serum and ascitic fluid levels of CIC's of chronic patients. These findings also correlated with the degree and severity of the clinical syndrome.

Acute Disease↗

PubMed1983

Immunologic studies of human schistosomiasis. II. Interrelationship of serum and ascitic fluid histamine, IgE and total eosinophils in acute and chronic human schistosomiasis.

Sera and ascitic fluid of 26 patients with acute and chronic schistosomiasis were studied for the determination of histamine levels, IgE and total eosinophil counts and their correlation with the clinical manifestations of the disease. Serum histamine levels were significantly increased in acute and chronically infected patients. Serum IgE levels were markedly increased in all patients with S. mansoni infection and S. haematobium infection and moderately elevated in chronic patients. Eosinophilia was found in 60% of patients with S. mansoni infection and in 83% with S. haematobium infection. Ascitic fluid analysis revealed the presence of IgE and high concentrations of histamine. There was also a significant positive correlation (p less than 0.01) between serum and ascitic fluid histamine levels, as well as to IgE levels. These results support the contention that histamine and other immune system components may play a role in the pathophysiology of different stages of schistosomiasis.

Acute Disease↗

PubMedDate not supplied

IgG4 FAST test in food allergic individuals: preliminary results.

We feel that one, the double blind oral food provocation protocol offers a reliable, realistic and objective method to make an observation and correlation of specific IgE and IgG4 antibodies to food allergy; second, these preliminary results thus far suggest a lack of "correlation" between history and skin tests, although there appears to be a better "correlation" between history and in vitro tests; third, these studies demonstrate a lack of "correlation" between skin tests and the presence of specific IgE and IgG4 antibodies to milk; and fourth, in spite of the positive symptom scores of the subjects, there was no direct relation between the numerical values of specific IgE and IgG4 milk antibodies to the oral milk provocation results.

Adolescent↗

PubMedDate not supplied

Dietary induction of sudden death syndrome in broiler breeders.

Sudden death syndrome in broiler breeders at the point of lay was a serious problem in Australia for 18 months. This condition was reproduced by a combination of dietary and management practices. Chickens fed a diet low in potassium, phosphorus, protein, and energy had plasma potassium and phosphorus levels significantly lower than the levels seen in the controls. The plasma values of the test breeders were similar to levels seen in field cases. There was a significant difference (P less than 0.01) in the venous acid-base balance between the test chickens and controls. Test chickens were alkalotic and had a 6% mortality rate between 18 and 30 weeks of age.

Acid-Base Equilibrium↗