Measles and rubella: old problems in a new generation.
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Biomedical subjects
Publications and source records attributed to S M Nelson.
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In a voice reaction time task, subjects named target digits that were horizontally flanked by noise digits or by a neutral symbol (#). For the control subjects, the noise digits were uncorrelated with the target digit, whereas for three experimental groups, the value of the noise digit predicted the target digit by an arithmetic rule (target = noise, target = noise + 1, target = noise - 1) on 75% of the trials. Patterns of reaction time facilitation and inhibition relative to the control condition among the four subject groups illustrated differing time courses of involuntary and expectancy-based priming. For prediction rules requiring an arithmetic transformation (expect N = 1 and expect N - 1), responses to predicted targets were slowed by response competition at short stimulus-onset asynchrony (SOAs) but greatly facilitated by expectancy at longer SOAs.
A team of trained technicians in a specially equipped mobile van conducted a mass screening effort on the Navajo Reservation from 1978 to 1980 to detect and refer individuals with ear disease and hearing loss; 15,890 school children were examined. The prevalence data and correlations of hearing level with ear disease are presented: 4.0% of the children had TM perforations, 2.3% middle ear effusions, 1.9% TM atelectasis, and 0.4% had sensorineural hearing loss. Microtia was found in 1:935, with a cluster on the Western one-fourth of the reservation. Cholesteatoma was rare. The patterns of ear disease are contrasted with other groups.
The in vitro activities of three new beta-lactam antimicrobial agents, cefodizime, ceftazidime, and aztreonam (formerly azthreonam), were compared with those of cefotaxime, cefuroxime, cefoxitin, and penicillin against 100 beta-lactamase-negative and 42 beta-lactamase-positive Neisseria gonorrhoeae strains. The three new antimicrobial agents showed excellent activity against N. gonorrhoeae regardless of beta-lactamase production. Cefodizime was as active as cefotaxime and more active than the other test antimicrobial agents. It inhibited all isolates at a concentration of less than or equal to 0.016 micrograms/ml.
The in vitro activity of Sch 29,482, a new oral beta-lactam antimicrobial agent, was compared with those of norfloxacin, rosoxacin, ampicillin, erythromycin, and tetracycline against 142 Neisseria gonorrhoeae strains. Sch 29,482 was as active as norfloxacin and rosoxacin. Its activity was greater than the other three antimicrobial agents. It inhibited 90% of the isolates, regardless of beta-lactamase activity, at a concentration of less than or equal to 0.06 micrograms/ml.
The in vitro activity of a new oral antimicrobial agent, norfloxacin (MK-0366), was compared with those of nalidixic acid, nitrofurantoin, co-trimoxazole, trimethoprim, sulfamethoxazole, cinoxacin, tetracycline, ampicillin, carbenicillin, and cephalexin against 628 urinary bacterial isolates. Norfloxacin was the most active antimicrobial agent tested against the gram-negative bacilli. It was less active than a few of the other antimicrobial agents against enterococci and Staphylococcus aureus.
Angiolymphoid hyperplasia with eosinophilia (Kimura's disease) is a relatively uncommon subcutaneous lesion, which can be confused with angiosarcoma. A case is presented. The differential diagnosis and therapy are discussed.