Influence of the thymic polypeptidic extract (TP2) on the number of antibody-forming spleen cells of the mouse injected with heterologous red cells.
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Biomedical subjects
Publications and source records attributed to S M Milcu.
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Based on clinical observations made in the "C.I. Parhon" Institute of Endocrinology and in a clinic of catching diseases in Bucharest, the authors have isolated an endocrine syndrome of occult tuberculosis. The disease shows signs and symptoms of endocrine glands involvement. The paper presents the pathogenesis, epidemic spread and endocrino-tuberculostatic management.
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Administration of the TP2 extract containing thymic polypeptides of low molecular weight (under 10,000 daltons) was found to stimulate the delayed hypersensitivity reaction in guinea-pigs injected with BCG. It was also found to reduce the hemagglutination titre in mice injected with the APR 8 influenza virus and to raise the antiflagellar agglutinins titre in rats injected with TH Salmonella vaccine. The cellular type of immune reactions was stronger than the humoral one.
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The thymus polypeptide extract TP1 administered to X-rayed animals shows a protecting effect on the level of serum anti-influenza antibodies in the rats inoculated with A2 influenza vaccine and reduces the haemagglutinating titres in the mice inoculated with the A PR8 influenza virus.
The authors studied 434 cases of thyroid carcinoma. The sex distribution showed a strong predominance of women (67%). The highest percentage (47%) appeared between 30 and 49 years. Histologically the folliculo-papillary aspect predominated. Thyroid cancer was associated with the following thyreopathies: in 75% of the cases with an anisofollicular adenomatosis, in 12% with a chronic thyroiditis, and in 0.4% with Graves's disease. Only in 13% of the cases no association was found with other thyreopathies. Between 1967 and 1975 no increase of the number of thyroid carcinomas was found.
Administration of thymus polypeptide (TP) extracts to the mouse inoculated with the A2 AICHI influenza virus strain, causes a significant decrease in hemagglutination titres in the lung cells suspensions of the treated animals as compared to the nontreated controls.
The authors correlated the aeroions variations in January, February and March 1963 with urinary 17-KS variations in 5 adult subjects. The results revealed that the excess of positive aeroions induced an increase of the urinary 17-KS eliminations, whereas the excess of negative aeroions induced a decrease.