[Influence of stress (electric and audiogenic) on the development of Walker 256 carcinosarcoma in rats].
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Biomedical subjects
Publications and source records attributed to S M Milcu.
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Six forms of regulation of neuroendocrine system pathology are here presented. For this pathogenic category it was proposed the term of "systemic neuroendocrine pathology" (1979) and that of "endocrine cybernosis (1971) for its clinical forms. Clinical and pathogenic peculiarities of endocrine blocking cybernoses with negative feed-back disappearance, substitution cybernose as in Graves-Basedow's syndrome and hormonal circadian rhythm troubles are described. The semiology of the clinical forms is partly known, but their pathogeny is still locally and regionally interpreted. There are primary and secondary lesions, characteristic of each clinical category of the systemic pathology, but the prevailing expression is the systemic one. The treatment of neuroendocrine cybernoses must be dominated by regulatory medication.
Evaluation of the role of cell-mediated immunity (CMI) in thyroid-gland pathology has been carried out by calculating the percentage of nonimmune (ER) and immune rosettes (EAC)--(erythrocyte-antibody-complement), i.e. of T--(thymus-dependent) and B lymphocytes (bursa equivalent) in the peripheral blood. The mean percentages found in the 10 normal subjects under study were of 65.8% ER (ranging between 56.6% and 74.9%) and 15.1% EAC (ranging between 12.2% and 17.9%. In the 8 nontreated patients with Graves' disease the means were of 77.5% and 12.9%, respectively. For the same parameter the following values were also found: in 6 patients in remission, 62.2% and 22.7%, respectively; in 8 patients with acute and subacute thyroiditis, 87.5% and 13.4%, respectively; in 7 patients with thyroiditis under remission, 64.1% and 24.2%, respectively.
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