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S M Marcus

Publications and source records attributed to S M Marcus.

At least 37 records · Page 2Linked to original sources

Use of succimer.

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Drug Industry↗

Adjunctive therapy of phenytoin overdose--a case report using plasmaphoresis.

Phenytoin is widely used as an anticonvulsant. In overdose situations phenytoin demonstrates saturable metabolic kinetics making treatment difficult. Phenytoin's high protein binding makes it a poor candidate for hemodialysis or hemoperfusion. We report a case of an attempted suicide in which plasmaphoresis was used in an attempt to lower plasma levels and reduce toxicity. A review of the use of plasmaphoresis in acute intoxications is included.

Adult↗

Oven-cleaner pads: new risk for corrosive injury.

Over a six-month period, the New Jersey Poison Information System received 61 calls related to exposures to alkaline corrosives. Seven of these calls related to a new oven-cleaner product, oven-cleaner pads. These pads are sealed in a protective plastic wrap and contain lye in excess of 5%. Use of these products requires careful opening of the seal and caution in application. Five of the callers sustained injuries from their exposure, and three of these sustained burns, one in the oral cavity and one in the eye. None suffered permanent sequelae, but the potential for such is considerable. The method of application, concentration of base, and prolonged exposure to a widely covered area may make this product particularly hazardous.

Adult↗

A regional poison control system. Effect on response to hypothetical poisonings.

Poisoning of young children frequently results in parents seeking help. Parents either telephone for poison treatment information or go directly to a physician's office, hospital clinic, or emergency room. To determine if a regional poison control system reduces the inappropriate use of medical treatment services, parents attending suburban and inner-city clinics were presented hypothetical pediatric poisoning episodes and asked how they would respond. Parents living in a state serviced by a regional poison information center (Massachusetts) telephoned for information significantly more often and consequently used medical treatment services 19% less than did parents living in a state with only local poison information centers (New Jersey). In both states, inner-city populations went for care whereas suburban populations called. Both inner-city and suburban populations responded to a regional poison center but to a different extent. More severe ingestions tended to increase the use of the regional center by the Massachusetts suburban population, whereas other populations tended to use even more direct services.

Ambulatory Care Facilities↗

The acoustic correlates of "speechlike": a use of the suffix effect.

The stimulus suffix paradigm has been used to establish the importance of precategorical acoustic storage (PAS) as a theoretical construct in the investigation of attention and speech perception. Morton and Chambers concluded that sounds must have typical "speechlike" properties extracted at an early stage of processing in order to act as suffixes. In this article we use the suffix effect to investigate the conditions under which a sound is treated by the acoustic system as speechlike. On the basis of our findings we then perform other studies that reaffirm the essentially precategorical nature of the memory source termed PAS by Crowder and Morton. In Experiments 1-13 we demonstrate the complex basis on which sounds are classified. Our experiments show that a completely regular sound, in which a single pitch pulse from a naturally spoken vowel was repeatedly reproduced, still produced a substantial suffix effect. In addition a natural sound had to be quite severely filtered before the suffix effect began to vanish. However, a combination of regularity and filtering proved very effective, the two dimensions dramatically interacting in neutralizing the effect of the sound as a suffix. In two further experiments (14 and 15) we show that the classification parameters can be shifted by changing the acoustic properties of the stimulus list. However, forcing the subjects to make a linguistic classification of suffix sounds did not lead to any changes in their potency as suffixes. The classification of sounds, and thus the suffix effect, is an acoustic question, not a subjective one. The distinction between subjective and acoustic influences was further demonstrated when subjects rated a variety of sounds for their naturalness and for their similarity to the original suffix (Experiments 17-22). These measures showed themselves sensitive to the filtering operations we performed but, unlike measures of suffix effectiveness, were insensitive to regularity. Another suffix that produced a full suffix effect was shown to be rated as very nonspeechlike. Contrary to recent claims, these results reinforce our view of a distinction between central, subjectively controllable factors and a strong precategorical effect that is automatic in action and is based on the decision of whether a sound is speechlike.

Adult↗

Multiple system involvement in chronic lead poisoning.

Whenever unusual physiological derangements occur in concert, an intoxicant should be considered. When exposure to lead exists, poisoning from that metal should be considered in an etiological determination. Treatment of such lead intoxications can result in reversal of abnormal physiology.

Adult↗