Biomedical subjects
S M Lim
Publications and source records attributed to S M Lim.
A pure class II MHC disparity does not induce rejection of cornea or heart grafts in the rat.
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Trans-Pacific sharing of kidneys requiring preservation for more than 50 hours: an analysis of 33 cases.
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Steroid treatment depresses the production of transplantation tolerance.
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Community attitudes to cystic fibrosis carrier testing in England: a pilot study.
Inexpensive and accurate carrier testing for cystic fibrosis (CF) will be possible in the near future. There are no existing studies on the attitudes of English persons in the community to carrier testing for CF or any other recessive disorder. We have conducted a trial study of 166 persons at two schools, two doctors' surgeries, and a family planning clinic. Only a minority had clear pre-existing knowledge of cystic fibrosis and its genetic nature. However, over 80 per cent of those questioned expressed interest in knowing their carrier status. Although it is well known that uptake can only be assessed when a service is in place, and while further studies are required to confirm that testing will be of interest to couples of reproductive age with no previous knowledge of CF, the data strongly suggest that there will be interest in community-wide testing for CF carrier status when such a test becomes available in the United Kingdom.
A requirement for continued graft presence in the maintenance of systemic tolerance induced by cyclosporin A (CyA) in rats.
We report on a requirement for the continued presence of a heart graft in the maintenance of systemic tolerance induced by cyclosporin A (CyA). Hearts from DA rats (RT1a) were grafted into PVG (RT1c) recipient. CyA-induced long-term survivors (LTS) bearing functioning heart grafts are systemically tolerant, as demonstrated by the significant prolongation (greater than 50 days) of donor-strain skin grafts. In contrast, donor-strain skins grafted 3 weeks after the removal of heart grafts from LTS are acutely rejected (median survival 10.0 days; P less than 0.005). Using an adoptive transfer assay, 5 x 10(7) splenic lymphocytes obtained from LTS 3 weeks after the removal of the heart grafts fail to mediate adoptive tolerance (median survival 17.0 days), in contrast to the tolerance achieved by splenic lymphocytes obtained from LTS with functioning heart grafts (median survival greater than 100 days; P less than 0.005).
The induction of allograft tolerance in immune rats.
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A technique of combined liver and pancreas transplantation.
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Splenectomy abrogates the ability of thoracic duct lymphocytes of tolerant rats to transfer suppression.
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Long-term residence of a graft is an insufficient stimulus for the induction of tolerance. Investigating the role of cyclosporine in class I-disparate heart grafts in the rat.
This study demonstrates that the induction of tolerance is possible across a class I only antigenic barrier that fails to produce heart graft rejection. However, the long-term residence alone of such a graft per se, does not necessarily lead to the establishment of systemic tolerance in the recipient. The important finding in this study with regard to the biology of allograft tolerance, is that while the class I antigen provides the stimulus, its presence alone is not sufficient for the induction of tolerance; indeed, the action of the Cyclosporine A (CyA) is a necessary adjunct to its induction.
The induction of tolerance by cyclosporine.
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Cyclosporine coverage during the risk period leads to 100% long-term graft acceptance in the rat.
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Unresponsiveness to class I antigens is not equal to tolerance to class I antigens induced by cyclosporine A.
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Heterotopic heart transplantation in the rat receiving FK-506.
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Identifying a susceptible period following cyclosporine A-induced tolerance of heart grafts in the rat.
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Minor and class I MHC incompatibilities do not cause rejection of heart grafts but influence the rejection of skin grafts.
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Cyclosporine A-induced acceptance of major histocompatibility complex-incompatible grafts differs immunologically from class I or minor antigen-mismatched grafts accepted in the absence of immunosuppression.
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A prospective randomized comparative trial of the Gravigard, Latex Leaf, Dalkon Shield and Multiload Cu 250 IUDs.
This prospective randomized trial in 843 patients compared the effectiveness and complications of 4 intrauterine devices. At 24 months the gross accidental pregnancy rate for the Dalkon Shield was higher than for the 7Cu200 (p less than 0.05) and the ML Cu250 (p less than 0.05). The 7Cu200 had a higher expulsion rate than the Dalkon Shield (p less than 0.01), Latex Leaf (p less than 0.001) and ML Cu250 (p less than 0.001). Use-related terminations were higher for the 7Cu200 than for the ML Cu250 (p less than 0.01). Removal for pelvic inflammatory disease was necessary in 8 women (2 for the Latex Leaf and 3 each for the 7Cu200 and Dalkon Shield). There was no significant difference in termination rates between the ML Cu250 and Latex Leaf but subsequently the Leaf has given problems with removal particularly in women who have defaulted follow-up for several years.