Search PubMed⌕ Search

Biomedical subjects

S M Kuznetsova

Publications and source records attributed to S M Kuznetsova.

At least 19 recordsLinked to original sources
PubMed1997

Intracellular distribution and characteristics of Ca(2+)-transporting systems in cells of ciliate protozoan Tetrahymena pyriformis.

A significant digitonin-sensitive calcium pool has been shown to exist in Tetrahymena pyriformis cells. In the presence of exogenic energy sources, calcium released from the digitonin-sensitive pool can be accumulated by mitochondria or endoplasmic reticulum. The kinetic characteristics of the mitochondrial and reticulum systems of Ca2+ transport and their sensitivity to various inhibitors were studied.

Adenosine Triphosphate↗
PubMed1992

Calorimetric study of interactions of toxin from Radianthus macrodactylus with erythrocyte membrane.

Differential scanning microcalorimetry, intrinsic protein fluorescence and SDS-electrophoresis have been applied for the study of the hemolytic toxin from sea anemone, Radianthus macrodactylus, when it is incorporated into pure sphingomyelin/water systems and upon its effect on the human and dog erythrocyte membranes. The results obtained by using these techniques showed that one molecule of toxin withdraws six sphingomyelin molecules from the cooperative transition. Effect of hemolytic toxin on human erythrocyte ghosts causes an appearance of a new heat sorption peak in their differential scanning calorimetric curve with a maximum of 36 degrees C and, moreover, it leads to a loss of one of cytoskeleton proteins (actin). These effects are essentially weaker in the case of dog erythrocyte ghosts. This suggests differences in the structural organization of human and dog erythrocyte membranes.

Animals↗
PubMed1990

[Ethnic characteristics of age-related changes in the development of electric activity of the brain during aging].

Clinico-electrophysiological examinations of the indigenous population of Azerbaijan and of Russians who had moved to the indicated region over 150 years before made it possible to define the ethnic traits of the ageing of the central nervous system. Overall 495 persons were examined. In Russians, the age-associated alterations in brain bioelectrical activity were found to set in 15 to 25 years earlier than in Azerbaijanians.

Action Potentials↗
PubMed1990

[Synergism in the action of gamma radiation and cardiac glycosides].

Synergism of gamma radiation with 137Cs and cardiac glycosides was investigated in experiments on mice and transplantable Raji tumor cells. A single ip administration of these drugs at nontoxic concentrations 30-60 min. after irradiation at the LD30/30 resulted in the survival of 13-20% of animals and the reduction of the mean survival time up to 8.4-12.5 days versus 22.3 days in the control group. Synergism was slightly decreased at administration of glycosides 24 h after irradiation. Glycosides introduced in the irradiated (at a dose of 1-2.5 Gy) human lymphoblastic line caused sharp suppression of lymphoma growth and cellular lysis in experiments in vitro. One hundred per cent death of cells was noted after the use of the drugs at mean toxic concentrations.

Animals↗
PubMed1990

[Age-related features of the functional state of the brain in patients with circulatory encephalopathy].

Complex clinico-physiological examinations was performed in 300 patients of middle and old ages with early and pronounced dyscirculatory encephalopathy of atherosclerotic and, in most cases, hypertensive etiologies. The cerebral hemodynamics was found to be relatively independent of the central one in patients with early atherosclerotic encephalopathy; the level of the systemic circulation and that of the median regional cerebral flow were found to correlate in early and advanced hypertensive encephalopathy cases. The cerebral function was shown to be more associated with the cerebral flow in the early encephalopathy in elderly patients than in middle-aged ones. The individual and personal traits of the patients were largely related to the disease stage rather than to the predominant etiological factor.

Adult↗
PubMed1990

[Amikacin in the treatment of infectious-inflammatory diseases in patients at a therapeutic hospital].

Amikacin sensitivity of 157 strains which caused infectious inflammatory diseases in patients of a therapeutic hospital was studied. It was shown that 52 and 42.9% of the isolates from patients with bronchopulmonary infections were highly and moderately sensitive to amikacin, respectively. 5 pneumococcal strains were resistant to amikacin. Among the isolates from urine of the patients with urinary infections there were no strains resistant to amikacin. Study of amikacin pharmacokinetics demonstrated expediency of antibiotic endobronchial administration to patients with bronchopulmonary diseases and aggravation of chronic purulent inflammatory processes. A favourable clinical effect of amikacin after its intramuscular or endobronchial administration was observed in 53.3% of the patients. In 30% of the patients the effect was satisfactory. In 16.7% of the patients the treatment failed. Satisfactory antibiotic tolerance in the majority of the patients was stated.

Amikacin↗
PubMed1989

A dynamic model for in-vitro evaluation of antimicrobial action by simulation of the pharmacokinetic profiles of antibiotics.

The general principles of in-vitro simulation of drug pharmacokinetic profiles for linear one-, two- and multi-compartment models are described. An in-vitro dynamic model constructed on the basis of these, incorporating a novel filtration unit to provide efficient filtration of drugs at constant inoculum size, was used to study the antimicrobial action of sisomicin on Escherichia coli A 20363, in conditions simulating the pharmacokinetic profile observed in humans after a single intramuscular dose of 1 mg/kg.

Anti-Bacterial Agents↗
PubMed1987

Polymorphism of heterochromatin areas on chromosomes 1, 9, 16 and Y in long-lived subjects and persons of different ages in two regions of the Soviet Union.

Variants of chromosome polymorphism were analyzed in long-lived individuals and in subjects aged 40-79 years (170 persons) in two regions of the Soviet Union. The results of this analysis allow the suggestion that there is an association between the individual variants of chromosome polymorphism as regards C heterochromatin and the longevity phenomenon. Large size C segments on the human Y chromosome and the long Y chromosome were found both in the Ukrainian and Abkhasian long-lived males. In the long-lived females the chromosome polymorphism variants were associated with a region of their residence. The long-lived females of Abkhasia had a decreased relative size of C segments on chromosome 1 and an increased absolute and relative size of C segments on chromosome 9, while in their Ukrainian counterparts there was an increased relative size of C segments on chromosome 1 and a decreased one on chromosome 16.

Adult↗