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Biomedical subjects

S M Hecht

Publications and source records attributed to S M Hecht.

At least 145 records · Page 8Linked to original sources
PubMed1971

Chemical modifications of transfer RNA species. Desulfurization with Raney nickel.

A single, modified nucleoside in Escherichia coli tRNA, 6-(3-methyl-2-butenylamino)-2-methyl-thio-9-beta-D-ribofuranosylpurine, has been desulfurized with Raney nickel to afford its probable biosynthetic precursor. The limitations of the reaction at the nucleoside and tRNA levels and its lack of inhibition of the amino acid acceptor activity of tRNA are described.

Catalysis↗
PubMed1971

Cytokinins: development of a potent antagonist.

A systematic search has resulted in the synthesis of a class of cytokinin antimetabolites. The development and biological properties of the anticytokinins are discussed in terms of one member of the class, 3- methyl - 7 - (3 - methylbutylamino)pyrazolo[4,3 - d]- pyrimidine.

Antimetabolites↗
PubMed1969

Cytokinin of wheat germ transfer RNA: 6-(4-hydroxy-3-methyl-2-butenylamino)-2-methylthio-9-beta-D-ribofuranosylpurine.

A new modified nucleoside is responsible, in part, for the cytokinin activity of transfer RNA from wheat germ. The structure as judged by mass spec-trometry is 6-(4-hydroxy-3-methyl-2-butenylamino)-2-methylthio-9-beta-D-ribofuran-osylpurine. Unequivocal synthesis afforded material having ultraviolet, mass spectral, and chromatographic properties identical with those of the natural product.

Chromatography↗