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Biomedical subjects

S M Hall

Publications and source records attributed to S M Hall.

At least 109 records · Page 6Linked to original sources

Partner support, psychological treatment, and nicotine gum in smoking treatment: an incremental study.

Smokers (N = 99) were randomly assigned to one of three conditions: nicotine gum (NG), nicotine gum plus psychological treatment (NG-PT), and nicotine gum plus psychological treatment and partner support (NG-PT-PS). Data were collected at Weeks 0, 4, 12, 26, and 52 from study start. Contrary to expectations, NG-PT-PS and NG-PT failed to increase abstinence rates. Subjects who were closer to their support partners had significantly lower abstinence rates with NG-PT-PS than with the other conditions, although not significantly at Weeks 26 and 52. Treatments without partner participation (NG-PT and NG) were significantly more effective for subjects who had an extremely close support partner outside the treatment setting than for those who did not at all weeks. The role of social support in smoking treatment is discussed.

Adult↗

A study of neuropathy in HIV infection.

A prospective study of possible aetiological factors for neuropathy associated with HIV infection was performed in 80 patients and 28 homosexual controls. At entry to the study twelve patients (15 per cent) had evidence of a generalized neuropathy not due to any other cause and a further three patients developed symptomatic neuropathy during a mean (SD) follow-up of 20 (7.5) months. All but two of these neuropathies were of the distal symmetrical sensory type. Electrophysiology was consistent with an axonal pathology and nerve biopsy confirmed this as the major pathological change. Warming threshold was the diagnostic test most frequently abnormal, sometimes in the absence of other electrophysiological abnormalities. No association was seen with opportunistic infection (cytomegalovirus, herpes simplex, Pneumocystis pneumonia, toxoplasmosis, Cryptococcus infection or tuberculosis). HIV proviral DNA could not be detected in paraffin sections of peripheral nerve in six patients with neuropathy. The presence of the neuropathy did not show significant correlation with depression of the number of CD4+ T cells in the blood, impaired T cell function tests, or IgG, IgM, or IgA levels. Immune complexes containing C1q, but not those containing IgG, IgM, IgA or C3c, were significantly more common among neuropathic patients (p = 0.01).

AIDS-Related Opportunistic Infections↗

Human listeriosis and paté: a possible association.

OBJECTIVES: To study trends in human listeriosis and determine possible sources of infection. DESIGN: Descriptive analysis of laboratory reports of human listeriosis together with a survey of subtypes of Listeria monocytogenes isolated from patients and foodstuffs and an interview survey of patients to obtain food histories. SETTING: United Kingdom and Republic of Ireland 1985 to 1990. RESULTS: There was a near doubling in the incidence of human listeriosis in England, Wales, and Northern Ireland between 1985 and mid-1989 followed by a sharp decline. The upsurge in cases was caused largely by two strains of L monocytogenes, which accounted for 30-54% of the annual totals. These strains were less common before 1987 and after July 1989. A survey of paté in England and Wales in July 1989 showed that it frequently contained L monocytogenes. A similar survey in July 1990 showed a reduction in the proportions of samples contaminated. In 1989 patés from a single plant (manufacturer Y) were more likely to be contaminated by L monocytogenes and at higher levels than those from other producers. Most strains of L monocytogenes recovered from manufacturer Y's paté in 1989 were indistinguishable from those responsible for the 1987-9 upsurge in human listeriosis and were uncommon among isolates from patés from other manufacturers and from a wide range of other foodstuffs. Patients infected with the types of L monocytogenes found in paté were significantly more likely to have recently eaten paté than those affected by other strains. The start of the decline in numbers of cases of listeriosis coincided with government health warnings on paté consumption and the suspension of supplies from manufacturer Y. CONCLUSIONS: Contamination of paté was a likely contributory cause of the increase in the incidence of listeriosis between 1987 and 1989.

England↗

Listeriosis surveillance: 1990.

The annual numbers of reports of listeriosis in England, Wales and Northern Ireland received by the PHLS Communicable Disease Surveillance Centre (CDSC) and the Division of Microbiological Reagents (DMR) have shown remarkable changes in recent years. There was a near doubling in 1987 compared to 1986; a further increase in 1988; a sharp decline in 1989 (which occurred in the second half of that year) and, finally, the total in 1990 was the lowest since 1984. The rise and fall particularly (but not exclusively) involved pregnancy-associated cases and illness caused by serotype 4. The epidemiological and clinical features reported in 1990 were otherwise similar to those reported in previous years and in other countries. Patients with the non pregnancy-associated (also called 'adult/juvenile') type were in the majority, most of whom had an underlying disorder associated with impaired immunity. The reason for the changes in reported incidence is not completely understood but is probably due to the emergence and disappearance of a common food source of the organism. There is, however, no cause for complacency. Diagnostic vigilance must be maintained and vulnerable groups should adhere to existing dietary advice.

Adolescent↗

Sarcoid neuropathy.

In a case of subacute sensory and motor polyneuropathy associated with sarcoidosis, multiple epineurial and endoneurial granulomas were demonstrated in a sural nerve. Neighbouring nerve fibres were displaced by the granulomas and some were undergoing axonal degeneration. Ultrastructural and teased fibre studies showed axonal atrophy and degeneration with secondary demyelination. Histochemical studies indicated the presence of HLA-DR antigen on epithelioid cells in the granulomas. A non-specific inflammatory process in the nerve does not cause significant primary demyelination.

Aged↗

Anesthesia and ventilation for the uremic child.

This article reviews the management of the uremic child from the perspective of an anesthesiologist and cardiopulmonary clinician. The acute stresses of anesthesia, surgery, and mechanical ventilation mandate a systematic, functional approach to addressing rapidly progressing complications that may occur in these patients. Chronic renal failure may be the result of many different renal diseases, but most share common implications during anesthesia. Furthermore, anesthesia can be associated with acutely decreased function of both normal and diseased kidneys.

Cardiovascular System↗

Partner interaction and smoking cessation: a pilot study.

This was an exploratory study of precessation interaction between 21 smokers and their partners enrolled in a partner support smoking treatment program. The aim was to identify the partner interactions and proposed quitting strategies that were associated with cessation. Significant results (p less than .05) and trends (p less than .10) were reported. Both smoker and partner interactions predicted cessation. Failure to quit was predicted by smokers' negative behavior (prosmoking statements, interrupting the partner, and criticism/rejection of help) and by partners' suggestion to disengage from the quitting process. Partner's suggestion to disengage may be a reaction to the smokers' negative behavior because it was positively correlated with it. Successful quitters and their partners proposed more self-help strategies than did nonquitters and their partners. Nonquitters proposed more cooperative strategies than did successful quitters. Thus, suggesting strategies that encourage autonomy and self-mastery, rather than dependence on another person, may lead to more positive outcomes.

Adult↗

Social support and relapse: commonalities among alcoholics, opiate users, and cigarette smokers.

Links between social support and relapse were examined in a study of alcoholics, cigarette smokers, and opiate users completing treatment for drug use (N = 221). Subjects were followed weekly until relapse for a maximum of 12 weeks after the end of treatment. Structural and functional social support and support for abstinence and drug use were investigated. With demographic variables and drug-treatment group controlled, greater structural support (as measured by an index of social integration and by partner status) predicted a lower risk of relapse. Greater experienced partner support for abstinence also predicted lower risk. Social network members' use of the subject's problem drug predicted heightened relapse risk, but the effect was not statistically significant. This study contributes to a cross-drug model of relapse. It highlights the importance of social integration and abstinence-specific functional support in predicting the risk of relapse, independent of the particular drug of abuse.

Adult↗

Effects of commitment to abstinence, positive moods, stress, and coping on relapse to cocaine use.

In a prospective study of 104 cocaine patients, a baseline assessment was conducted while Ss were in treatment. After treatment completion, Ss were assessed once a week for 12 weeks, then 6 months from study start. A goal of absolute abstinence, greater expected success in quitting, and positive moods predicted a lower risk of a lapse in the first 12 weeks of follow-up. Stress (negative moods, physical symptoms, hassles, and life events) did not predict. Use of more coping strategies predicted abstinence for Caucasian but not for African-American Ss. Baseline measures of expected success and desire to quit predicted continuous abstinence at 6 months but not at statistically significant levels. Results suggest that solidifying abstinence goals and enhancing positive moods may facilitate early abstinence.

Adult↗

Evaluation of a new method of neural anastomosis using nitrocellulose paper.

Nerve regeneration was examined in 108 mouse sciatic nerves in a prospective morphometric study in which a new anastomotic technique using nitrocellulose paper was compared with conventional suturing and simple sectioning. Mice were randomly allocated to one of the three arms of the trial and sciatic nerves were examined following surgery at time intervals up to 8 weeks. Serial sections were taken for qualitative and quantitative morphometric analyses. Counts demonstrated that the rate of regeneration was faster in the nitrocellulose group than following nerve section alone, but that the suture group was even better. However, 8 weeks after surgery, there were no significant differences in myelinated axon counts 4mm distal to the site of section between any of the experimental groups. The superlative regenerative capacity of rodent axons may limit the applicability of this model to human nerve tissue.

Anastomosis, Surgical↗

Relapse prevention.

Although knowledge about relapse prevention is still at an early stage, the extant data highlight the importance of several constructs. 1. Motivation for abstinence remains central. The construct itself is often clouded because of its association with mystical notions such as willpower and self-control. We know that manipulation of environmental events can increase motivation. These interventions are effective, however, only as long as the contingencies are in effect. We need to develop and evaluate strategies for transferring contingency management to the natural environment, that is, to institutions and groups that can perpetuate them for the long term. Also, clarification of the kinds of abstinence goals needed to prevent relapse is important. 2. Coping skills have been studied by several investigators, but research on these, except for job-finding skills, is not encouraging. The skills usually taught may be too basic. Skills training oriented to complex targets, such as building nondrug-using networks, may be useful and should be further explored. 3. Social support is clearly important, yet we do not know how best to use it to promote abstinence. The little research available suggests that both familial and nonfamilial systems should be mobilized. We need to define abstinence-promoting supportive behaviors, identify and engage important support systems in treatment, and help patients expand their nondrug-using contacts. 4. Negative affect may be causally related to relapse. We need to continue efforts to identify dysphoric patients and develop interventions to ameliorate dysphoria concurrent with drug abuse treatment (cf. Zweben and Smith 1989). 5. Drug cue reactivity and extinction to drug cues have been demonstrated in the laboratory. What is needed in this promising line of research are (1) investigation of cues and cue-reactivity phenomena in the natural environment or in conditions closely mimicking that environment and (2) extinction methods that transfer from the treatment setting to the outside world. Other phenomena are not well understood but seem intuitively important. Maladaptive ways of responding to lapses, such as the AVE, are included here. Another is stress, which our patients and our clinical intuition tell us must play a role in relapse. Its exact role is far from clear.

Humans↗

Experimental frostbite: freezing times, rewarming times, and lowest temperatures of pig skin exposed to chilled air.

Frostbite was produced in the skin of five Hanford Miniature Swine by exposing local areas to chilled air (-75 degrees C) for 1, 3, 5, 10, or 20 min. A copper-constantan thermocouple was inserted into the dermis to measure the temperature. The mean freezing time (the time required to reach 0 degrees C) was approximately 1.9 min. The mean lowest temperatures were 8.8, -15.7, -20.9, -22.5, and -23.4 degrees C for the 1-, 3-, 5-, 10-, and 20-min freezes, respectively. The mean times to rewarm the skin to 25 degrees C were 3.1, 4.5, 5.5, 7.0, and 8.6 min for the 1-, 3-, 5-, 10-, and 20-min freezes, respectively. Significant linear correlations existed between duration of freeze and rewarming times, duration of freeze and lowest temperature, and lowest temperature and rewarming times.

Animals↗

Detection of Eperythrozoon suis DNA from swine blood by whole organism DNA hybridizations.

A procedure is described for isolating Eperythrozoon suis DNA of sufficient quantity and purity to serve as a probe in whole-organism DNA hybridizations for detecting parasitized swine. The E. suis organisms were isolated from the blood of infected swine; the DNA was recovered and digested with restriction endonucleases and resolved on agarose gels. In DNA hybridizations using recovered E. suis DNA, blood samples from parasitized swine could be differentiated from uninfected, control samples. A high salt lysate recovery technique was used in sampling swine whole blood for E. suis DNA and found to offer many advantages in the collection and recovery process.

Animals↗