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Biomedical subjects

S M Golden

Publications and source records attributed to S M Golden.

26 records · Page 2Linked to original sources

Skin craters--a complication of transcutaneous oxygen monitoring.

Continuous transcutaneous oxygen monitoring has become standard practice in the management of infants who require supplemental oxygen. Previously described complications of tcPO2 monitoring consist of prolonged intense skin erythema or first degree burns. Two cases of premature infants who developed numerous, hyperpigmented skin craters following prolonged tcPO2 monitoring are reported. Although these lesions appear to be harmless, they have not resolved with time and long-term cosmetic implications are unknown.

Burns↗

Bilateral clinical anophthalmia: drugs as potential factors.

This case of bilateral clinical anophthalmia presents a host of interrelated drug reactions and potential teratogenic factors. While none of the drugs ingested by the mother has a high teratogenic potential, drug interactions, toxic potentiation, and unknown incompatibilities cannot be excluded. Although a single etiologic agent is not incriminated, the drugs ingested during pregnancy and their toxic effects and interactions are discussed. Use of drugs during pregnancy should be limited to those clinically indicated.

Abnormalities, Drug-Induced↗

Interobserver and method variability in tuberculin skin testing.

Accurate measurement and interpretation of tuberculin skin tests is essential both to avoid unnecessary prophylactic treatment with potentially hepatotoxic drugs and to ensure the proper institution of therapy in tuberculin-positive individuals. Although two methods are currently used for reading tuberculin skin tests, palpation and ballpoint, the optimal technique has not been established. We compared measurements obtained by each method on 101 patients tested with intermediate tuberculin purified protein derivative. Fifty-eight of these patients were also tested using Mono-Vacc. Excellent interobserver agreement among the five raters was demonstrated for both the palpation and ballpoint techniques. There was no significant difference between the two methods for any reader using the normal 10-mm cutoff point for a positive intermediate tuberculin purified protein derivative test. For any individual observer the decision as to whether the test was positive or negative was unaffected by the method in at least 93% of readings. We conclude that readings by physicians using palpation and ballpoint methods are comparable for clinical decision making.

Adolescent↗