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Biomedical subjects

S M Fox

Publications and source records attributed to S M Fox.

61 records · Page 4Linked to original sources
PubMedDate not supplied

Changes in plasma cortisol concentrations in bitches in response to different combinations of halothane and butorphanol, with or without ovariohysterectomy.

Changes in plasma cortisol concentrations were assessed in bitches in response to nine treatments: control, anaesthesia, analgesia, analgesia followed by anaesthesia, anaesthesia followed by analgesia at intubation, anaesthesia followed by analgesia at extubation, anaesthesia plus surgery, analgesia followed by anaesthesia plus surgery, and anaesthesia plus surgery followed by analgesia. The anaesthetic was halothane, the analgesic was butorphanol (0.4 mg kg(-1)) and the surgery was ovariohysterectomy. Blood samples, for plasma cortisol assays, were taken regularly from before treatment for five hours and then again after 24 hours. A small transient rise in plasma cortisol concentration in the control group was attributed to mild distress associated with novel experiences. A more pronounced and protracted rise in cortisol concentration in the analgesia group was ascribed to a dysphoric state of bitches under the influence of the agonist-antagonist butorphanol. Halothane anaesthesia alone resulted in no change in plasma cortisol concentration. When butorphanol was given after anaesthesia was induced or while the animal was still under the influence of anaesthesia (immediately after tracheal extubation), there was no immediate rise in plasma cortisol concentration and low concentrations were maintained for up to 60 minutes after halothane withdrawal. A marked rise in plasma cortisol concentration, which was sustained above pretreatment values for at least five hours, occurred in all surgery groups. Giving intravenous butorphanol 30 minutes prior to surgery had no effect on the surgically-induced rise in plasma cortisol concentration and no effect on the postsurgical plasma cortisol concentration. In contrast, butorphanol given at extubation did reduce plasma cortisol concentrations during the postsurgical period. These observations did not support the hypothesis that preoperative use of butorphanol would reduce the cortisol response after surgery under halothane anaesthesia.

Analgesia↗
PubMedDate not supplied

Ununited anconeal process: lag-screw fixation.

A technique of lag-screw fixation for ununited anconeal process is described, and the results of surgery in eight dogs (on 10 elbows) treated by this technique are presented. Approximation of the process was confirmed postoperatively, and union was confirmed by radiographic followup in six of the 10 forelimbs from two-to-six months after surgery. Four other cases were lost to radiographic follow-up. This report of a limited number of cases suggests encouraging results obtained by lag-screw fixation.

Animals↗
PubMedDate not supplied

Reconstruction of the medial collateral ligament for tarsocrural luxation in the dog: a preliminary study.

Seven cases of tarsocrural subluxation/luxation resulting from ruptures of the medial collateral ligament were treated by double prosthetic replacement. The technique was a revision of an earlier described method without the use of metallic implants. Six (100%) of six cases not involving additional joint fractures had excellent clinical results with minimal compromise to range of joint motion. In three (50%) of six cases where braided polyester sutures were implanted as the prosthesis, fistulating tracts developed. Drainage resolved with removal of the suture in each of these three cases, and two of the three proceeded to excellent results after replacing the braided suture with monofilament suture.

Animals↗
PubMedDate not supplied

Anesthetic effects of ketamine or isoflurane induction prior to isoflurane anesthesia in medetomidine-premedicated dogs.

Dogs were given medetomidine (10 microg/kg body weight, intramuscularly) followed in 10 minutes by either ketamine (4 mg/kg body weight, intravenously) or isoflurane mask induction and maintained on isoflurane for 30 minutes. Medetomidine induced lateral recumbency in all dogs. Endotracheal intubation was faster and smoother when dogs were given ketamine than when induced with isoflurane. Analgesia was excellent in all groups. Respiratory depression was more profound when dogs were given ketamine. Recovery quality was smooth and similar among all groups. Medetomidine-premedicated dogs could be induced with either ketamine or isoflurane and maintained on 1.3% isoflurane to achieve good analgesia with smooth recovery from anesthesia.

Anesthesia, Inhalation↗