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Biomedical subjects

S M Feldman

Publications and source records attributed to S M Feldman.

32 records · Page 2Linked to original sources
PubMed1977

Course evaluation by committee.

An intradepartmental course evaluation committee has been established in the Department of Community Dentistry at the University of Louisville School of Dentistry. This committee's review of student evaluation mechanisms was a major focus in the assessment of all departmental courses. An evaluation technique, based on a comparison of existing student evaluation mechanisms against criteria established by the committee and approved by the departmental faculty, was designed and applied. The committee was viewed as successful by departmental course directors; however, its suggestions were not widely implemented by the departmental faculty. Several reasons are cited for this, as well as suggestions for future modifications of the committee's procedures.

Curriculum↗
PubMed1975

Reversal of hypercoagulable state by bilateral nephrectomy.

The hypercoagulable state associated with select cases of glomerulonephritis is difficult to diagnose by standard laboratory techniques but is clinically manifested by recurrent shunt and fistula thrombosis which may be refractory to anticoagulant therapy. Bilateral nephrectomy reversed this hypercoagulable state. After renal allograft, however, the patient experienced hyperacute rejection, and transplant nephrectomy was required to cure the recurrent hypercoagulable state. The mechanism of this previously unreported phenomenon and its implications with regard to renal transplantation are discussed.

Adult↗
PubMed1967

Somatosensory thalamic neurons: effects of cortical depression.

Deafferented somatosensory thalamic neurons showed hyperactivity, followed by greatly reduced activity, after initiation of cortical spreading depression; local cooling of sensorimotor cortex was followed only by the inactive phase. Stimulation of contralateral midbrain reticular formation during the inactive phase failed to induce the typical increase in discharge rate of somatosensory thalamic neurons, but produced desynchronization in unaffected cortex. These results indicate that corticothalamic discharge is necessary for sustaining the ongoing activity of deafferented somatosensory thalamic neurons and for maintaining their responsiveness to stimulation of the reticular formation.

Animals↗
PubMedDate not supplied

Sodium nitroprusside (SNP) hypotension: intracranial pressure (ICP) and hemodynamics in pial arteriole in the rat.

A detailed description is made of an acute closed cranial window method. The method is used for the study of cerebral pial microcirculation by intravital microscopy in the rat. Using these methods and techniques, the effects of systemic hypotension by SNP, i.v., on pial microvessel hemodynamics and on ICP were simultaneously measured and characterized under normophysiological conditions. The pH, PO2, PCO2 and temperature of the artificial cerebrospinal fluid (CSF) in the closed cranial window, intermittently measured, remained relatively constant, 30 to 60 min following the period of stabilization of the preparation. The infusion of SNP (6.2-35.0 micrograms/kg/min, 0.02% sol., i.v.) significantly decreased BP (52.1 +/- 13.4 mm Hg, mean +/- SD). From measurement of microvessels internal diameter (I. D.) and microhemodynamics, significant increases in pial arteriolar I.D. (from 35.4 +/- 10.1, microns, to 47.1 +/- 5.7, microns, mean and S.D., 33.0%) and estimated bulk flow (51.2%), occurred during the hypotension. The changes in hemodynamic parameter were predominantly in the arteriolar system. Only minimal changes in the venular diameter occurred during the SNP hypotension. The observed moderate (22.0%) increase in ICP during SNP hypotension in pentobarbital anesthetized rat correlates well with the microhemodynamic changes of the cerebral microcirculatory system.

Animals↗