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Biomedical subjects

S M Bergman

Publications and source records attributed to S M Bergman.

27 records · Page 2Linked to original sources

The value of whole lung tomography in the early detection of metastatic disease in patients with renal cell carcinoma and testicular tumors.

The value of whole lung tomography was compared to chest x-rays in patients with renal cell carcinoma and germ cell testicular tumors. We studied 83 patients with testicular tumors and 34 with renal cell carcinoma. At least 1 metastatic lesion was present on whole lung tomography in 11 of 64 patients (17 per cent) with testicular tumors and 2 of 21 (10 per cent) with renal cell carcinoma who had negative chest x-rays. Of the patients with a solitary lesion on the chest x-ray 3 of 10 (30 per cent) with testicular tumor and 5 of 11 (45 per cent) with renal cell carcinoma had multiple metastatic lesions on whole lung tomograms. Falsely positive chest x-rays were noted in 6 of 15 patients (40 per cent) with renal cell carcinoma and 6 of 16 (37 per cent) with testis tumor. These falsely positive results were caused by overlapping shadows, vessels or granulomas.

Adenocarcinoma↗

Urinary tract obstruction secondary to cerebrospinal fluid cysts.

Bilateral hydroureteronephrosis secondary to mechanical kinking of the ureteral-conduit anastomosis or ureteral compression caused by a large intra-abdominal cerebrospinal fluid cyst should be considered in patients who have ventriculoperitoneal shunts, abdominal ascites, and deteriorating upper tracts. Therapy directed at correction of the cerebrospinal fluid cyst should be sufficient to correct the urologic dysfunction.

Abdomen↗

Abnormal seminiferous tubule cells associated with choriocarcinoma: immunoperoxidase study.

A case is presented of widely metastatic choriocarinoma, associated with an intratubular proliferation of atypical germ cells in the testis and a minute adult cystic teratoma. Immunoperoxidase study of the intratubular germ cells did not confirm their trophoblastic origin. Intratubular proliferation of undifferentiated germ cells may be associated with choriocarcinoma.

Adult↗

Correlation of the cell surface antigens with stage and grade in cancer of the bladder.

We examined 76 bladder tumors of various stages and grades for the presence of the ABO (H) cell surface antigen, using the specific red cell adherence technique. Of the grade I lesions studied 70 per cent were positive for the cell surface antigen and none of the 26 grade III tumors retained the antigens. When correlated with clinical stage the tumors showed no antigens for those of stages B1 to D, while 12 of 16 stage A lesions were positive for the antigen. When stage A lesions were studied and the findings were correlated with recurrence and metastasis/invasion rates the cell surface antigen was present on the initial tumor in only 1 lesion that recurred at an invasive stage. The findings of this study show that the specific red cell adherence technique may be valuable for predicting malignant potential in low grade, low stage cancer of the bladder. If supported by further investigation this technique may offer the capability of selecting low grade, low stage bladder tumors that are destined to invade or metastasize while they are at curable stages.

ABO Blood-Group System↗

Complication with mechanical stapling device in creation of ileoconduit.

Of 296 patients with pelvic malignancy and ileal urinary conduits, urinary tract calculi developed in 14. Calculi which ordinarily require surgical intervention because of their size may pass spontaneously in patients with ileoconduits because of the presence of a chronically dilated colllecting system and the surgical elimination of three of the four sites of stone impaction (pelvic brim, ureterovesical junction, and ureteral orifice). In 1 patient multiple calculi developed around the surgical staples used to create the proximal end of the ileal conduit. We recommend that autosuture with stapling devices not be used to create the proximal end of an ileal urinary conduit.

Carcinoma↗

Postoperative management of patients with pheochromocytoma.

The optimal preoperative and postoperative management of patients with pheochromocytoma demands a multidisciplinary approach. We report on 5 recent patients to illustrate the large volumes of fluid needed in the early postoperative period. This large fluid requirement is owing to a combination of a change in vascular compliance after excision of a pheochromocytoma, the residual effects of specific preoperative medications (phenoxybenzamine and alpha-methyl-p-tyrosine) and the loss of fluid into the retroperitoneal compartment (third space) produced by extensive dissection. It takes 3 half-lives (36 hours) to dissipate the effects of phenoxybenzamine and alpha-methyl-p-tyrosine, which corresponds to the time in which these patients require large volumes of intravenous fluids.

Adrenal Gland Neoplasms↗

Block copolyurethanes in the urinary system.

Free floating segments of block copolyurethane were implanted into rat bladders and compared with similar implants of silicone rubber. This urethane was far superior to silicone rubber in its ability to withstand incrustation in the rat bladder. Ten dogs had a segment of right ureter replaced by a tubular segment of smooth (or film) urethane and were followed with intravenous urography. At 1 month, eight of 10 dogs had right hydronephrosis. At the time of sacrifice (4 or 8 months) seven dogs had reduced hydronephrosis, and in three dogs intravenous urography was unsatisfactory for grading. Only two of the ten dogs had significant urinary infection. A smooth protein-like coasting appeared along the lumen of the graft, incrustation was minimal, and new mucosa and smooth muscle regeneration was seen. This material was well tolerated in the urinary tracts of dogs and rats.

Animals↗