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Biomedical subjects

S M Andrews

Publications and source records attributed to S M Andrews.

22 records · Page 2Linked to original sources

Distribution of trace element pollutants in a contaminated grassland ecosystem established on metalliferous fluorspar tailings. 2: Zinc.

Concentrations of zinc in vegetation, invertebrates and small mammals in a grassland ecosystem derived from a mine waste vegetation scheme indicated the high concentration of zinc in the original tailings. However, the considerable differences in soil and vegetation zinc concentrations between the tailings and an uncontaminated site were not reflected in the invertebrate and small mammal communities. Invertebrate zinc levels and total body concentrations in Microtus agrestis L. (field vole) and Sorex araneus L. (common shrew) suggested a notable buffering of zinc absorption and tissue accumulation in the presence of substantially elevated dietary zinc. In the small mammals the skeleton appeared to function as the major storage site for zinc, possibly contributing to homeostasis in the soft tissues.

Journal Article↗

Distribution of trace element pollutants in a contaminated grassland ecosystem established on metalliferous fluorspar tailings. 1: lead.

Concentrations of lead in vegetation, invertebrates and small mammals in a grassland ecosystem evolved from a mine waste revegetation scheme indicated the high concentration of lead in the original tailings. Lead levels in invertebrates reflected dietary concentrations and feeding strategy, a pattern also true of the indigenous small mammals. Total body and tissue concentrations of lead in the herbivorous Microtus agrestis L. (field vole) and insectivorous Sorex araneus L. (common shrew) were significantly higher in the contaminated grassland than in an uncontaminated area, but concentration ratios (body:diet) were less than unity and there was no evidence of age-dependent accumulation of lead.

Journal Article↗

The metabolism and disposition of [2-14C]diazepam in the streptozotocin-diabetic rat.

The oral administration of [2-14 C]diazepam to streptozotocin (STZ)-diabetic rats resulted in decreased faecal and biliary levels of metabolites with a concomitant rise in urinary radioactivity when compared to control values. This situation was reversible upon insulin treatment. The increased urinary metabolite excretion could not be ascribed to the diuresis observed in STZ-diabetic rats. No alteration in the phase I or II routes of [14C]diazepam metabolism in diabetic animals was observed either in vivo or in vitro. Following i.v. administration of [2-14C]diazepam, blood 14C levels in diabetic rats were elevated above those observed in normal animals.

Animals↗