Search PubMed⌕ Search

Biomedical subjects

S Lundberg

Publications and source records attributed to S Lundberg.

At least 73 records · Page 4Linked to original sources
PubMed1979

Serum enzymes with special reference to CK-MB following coronary bypass surgery.

In a consecutive series of 25 coronary bypass operations, the postoperative serum activity levels of total creatine kinase (CK) and its more heart-specific isoenzyme CK-MB were examined and related to the levels of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and thermostable lactate dehydrogenase (LD-T), to electrocardiographic (ECG) findings and to surgical characteristics. Detectable CK-MB activity was found in all patients, usually appearing while the operation was still in progress. Peak CK-MB occurred earlier than peak total CK. There was no ECG evidence of myocardial infarction in any patient. The degree of postoperative CK-MB elevation, however, correlated to the duration of extracorporeal circulation (ECC) and aortic cross-clamping (AC). After 120 min of ECC and 70 min of AC, release of CK-MB, as well as of the other enzymes studied, increased considerably. There was a significant correlation between high CK-MB activity and high early postoperative activities of total CK, ASAT and LD-T. When CK-MB determinations are not available, ASAT is preferable to total CK or LD-T in the early evaluation of operative myocardial injury. From the fourth postoperative day, only LD-T is informative in this respect; a second rise of ASAT and ALAT is probably of hepatic origin.

Adult↗
PubMed1977

Latent carcinoma of prostate at autopsy in seven areas. The International Agency for Research on Cancer, Lyons, France.

A world-wide comparative study of the frequency and characteristics of latent carcinoma of the prostate was undertaken in seven areas, using standardized methods and "blind" microscopic evaluation in order to reduce selection and observer bias. The morphological features of 350 latent carcinomas found in 1,327 prostates were examined. Two Chinese populations, from Hong Kong and Singapore, showed a low frequency of latent carcinoma in comparison with western Europeans in Sweden and the Federal Republic of Germany and negroes from Jamaica; an intermediate position was found for Israelis and black Ugandans. The frequency of small latent carcinomas was about 12% in all the areas investigated and did not vary with age. Rates for larger latent carcinomas increased sharply with age ans showed an area-to-area variation resembling that of clinical carcinoma of prostate. The small carcinomas were almost exclusively situated in the outer half of the prostate and latent carcinomas of all sizes were evenly distributed between the anterior and posterior halves of the prostate and the right and left sides of the outer prostatic shell. Certain disagreements in diagnosis were noted when the sections from each area were evaluated independently by a different pathologist. Most of these disagreements were resolved by re-reading the sections; their occurrence had no significant effect on the geographical comparisons.

Age Factors↗
PubMed1976

Evaluation of a new spirometer based on a fluidistor technique.

Using a mechanical model and human subjects a new spirometer based on fluidistor principles was evaluated. At normal minute volumes the fluidistor was accurate to within +/-5% when compared with a Bernstein spirometer. It underread at low volumes and overread at high. Prolonged expiratory time constant as well as the use of gas with low density increased the error. The instrument was somewhat sensitive to variation in breathing frequency and gas flow pattern but insensitive to moisture. The resistance to gas flow of the instrument itself was fairly high. The fluidistor is based on a sound and simple principle (no movable parts). It proved to be stable and easy to handle and accurate enough for clinical use in anaesthesia and intensive care. The tendency of the spirometer to underread at low flow and to overread at high flow could possibly be substantially reduced if the instrument was provided with several flow heads so that the oscillation volume could be individually adapted to the gas flow rate to be studied.

Airway Resistance↗
PubMed1975

Airway compliance during artificial ventilation.

The relationship of anatomical deadspace to transpulmonary pressure was studied in eight subjects awake, breathing spontaneously without endotracheal intubation, and anaesthetized intubated and ventilated artificially. Anatomical deadspace was determined according to the equal area method (Fowler) using carbon dioxide as a tracer gas. Volume measurements were performed using a pneumotachograph. Transpulmonary pressure was measured using an oesophageal balloon and a catheter which was connected to the mouthpiece during spontaneous breathing and inserted into the endotracheal tube during artificial ventilation. Anatomical deadspace was approximately the same during artificial ventilation and spontaneous breathing, despite bypass of the upper airway during anaesthesia. Anatomical deadspace was related linearly to transpulmonary pressure. The regression lines indicated an airway compliance of 3.6 ml/cm H2O during spontaneous breathing and 7.4 ml/cm H2O during artificial ventilation. The alteration in airway compliance caused by artificial ventilation is ascribed to a reduction in bronchial muscle tone.

Adult↗