Search PubMed⌕ Search

Biomedical subjects

S Ludwig

Publications and source records attributed to S Ludwig.

At least 127 records · Page 7Linked to original sources

Child homicide: emergency department recognition.

Homicide is escalating as a cause of sudden death in childhood. With the ever-rising rate of child abuse in the United States, the emergency physician is increasingly likely to encounter cases of attempted homicide. In order to improve survival in such cases, the emergency department (ED) staff must be alert to the subtle signs and symptoms of this form of trauma and be prepared to institute life-saving therapy. We reviewed 12 cases of child homicide seen in our ED between 1981 and 1983 and summarized the findings on these unfortunate children. The typical victim was a young child in the second half of the first year or in the second year of life. The most common forms of fatal injury were CNS injury and abdominal trauma. In both types of injuries, there were often subtle findings on external physical examination. It was important for the physician to have a high index of suspicion based on a protean chief complaint, a lack of preceding history of illness, the time of presentation to the ED, and more subtle physical findings such as minor skin bruising, retinal hemorrhage, and distended abdomen. A low hematocrit was also suggestive of traumatic cause for the child's critical state. In addition, autopsy findings for the 12 patients are presented.

Autopsy↗

Rhabdomyolysis and myoglobinuria as manifestations of child abuse.

Rhabdomyolysis should be suspected in cases of physical child abuse in which there is extensive soft tissue injury. It is easily investigated using the urinalysis and serum CPK levels. Renal failure is the most common complication and manifests itself as acute tubular necrosis, sometimes accompanied by the following specific laboratory abnormalities: elevated creatinine-to-BUN ratio, hyperkalemia, and myoglobinuria. Treatment is aimed at the preservation of renal function and the prevention of complications caused by electrolyte abnormalities. A full recovery can be expected for adults with this disorder, but information about the pediatric population is sparse. Our series suggests rapid improvement with appropriate therapy.

Acute Kidney Injury↗

An intervention to improve follow-up of patients with otitis media.

We evaluated the effects of an educational intervention and telephone reminders on compliance with medication-taking and appointment-keeping for children with otitis media. During an initial interview we examined parents' health beliefs and other factors associated with compliance in our outpatient setting. The children were then systematically assigned to one of five study groups (G1-5). Parents in G1 received an educational session with a nurse and two follow-up telephone reminders. Parents in G2 received only two telephone reminders. Parents in G3 met with the nurse for an educational session only. Parents in G4 were exempted from interventions, while parents in G5 were exempted from the interventions and the initial interview. The telephone reminder significantly increased the return rate for follow-up appointments (p less than 0.05). This effect was not enhanced by combining it with an educational intervention focusing more on medication compliance. Relatively simple and inexpensive interventions such as the ones described here improve follow-up appointment-keeping for children with otitis media. This enhanced compliance behavior is important in obtaining better health outcomes for children with acute illnesses.

Acute Disease↗

Objective evaluation of symptomatic alkaline reflux after antrectomy.

The purpose of this study was to compare the endoscopic and histologic findings in gastric mucosa, the total bile acids in the gastric contents, and the gastric emptying of a solid food in symptomatic and asymptomatic patients after vagotomy and antrectomy. Eleven male patients with typical symptoms of alkaline reflux were compared to six asymptomatic patients. There were no significant differences between the groups in output or concentrations of bile acid in fasting gastric juices. Evidence for gastritis by endoscopic or histologic features was present in asymptomatic as well as symptomatic patients. Gastric emptying of radiolabeled liver was faster in the symptomatic group, but the difference was not significant. In conclusion, these tests do not distinguish between patients with symptoms of alkaline reflux and asymptomatic patients after vagotomy and antrectomy.

Bile Acids and Salts↗

Shaken baby syndrome: a review of 20 cases.

Twenty cases of shaken baby syndrome are reviewed to determine important signs, symptoms, physical findings, laboratory parameters, and prognosis. The signs and symptoms of this form of head trauma are nonspecific. The findings may mimic infection, intoxication, or metabolic abnormalities. Diagnosis depends on a high index of suspicion and the physical findings of a bulging fontanelle, head circumference greater than the 90th percentile, and retinal hemorrhage. The finding of bloody fluid from a lumbar or subdural tap is also highly suggestive. Computed cranial tomography findings confirm the diagnosis. The prognosis in the shaken baby syndrome is poor. Three of our 20 patients died and ten others sustained significant morbidity. The emergency physician must be alert to making this diagnosis in order to promptly institute therapy for acute head trauma.

Brain Injuries↗

Management of lymphadenitis in childhood: the role of percutaneous needle aspiration.

Bacterial lymphadenitis occurs commonly during childhood, but the preferred initial therapy has not been clearly established. We studied lymphadenitis in children to determine the course of patients with fluctuant and nonfluctuant infections, and to assess the role of percutaneous needle aspiration as a form of therapy. Of 32 patients diagnosed as having lymphadenitis, 30 were followed successfully (26 with initially nonfluctuant and four with initially fluctuant infections). Fluctuance subsequently developed in four of 26 lymph nodes that were initially firm to palpation. In all eight children with fluctuant lesions the infections were resolved following percutaneous needle aspiration and antibiotic therapy, and 25 of 26 with initially nonfluctuant infections were cured with antibiotic therapy alone or with antibiotics accompanied by percutaneous aspiration when fluctuance developed (four cases). Thus we recommend initial percutaneous aspiration for the treatment of lymphadenitis whenever abscess formation is detected clinically.

Adolescent↗

Pediatric cardiopulmonary resuscitation. A review of 130 cases.

Cardiopulmonary resuscitation (CPR) records of 130 pediatric patients with cardiac arrest were reviewed. Ninety-six resuscitations were performed on patients hospitalized on the Medical and Surgical units of the Children's Hospital of Philadelphia (HP) and 34 on Emergency Department patients (EDPs). In HP, initial survival was 90%. In 27% of HPs, airway and breathing techniques alone were life saving. A mean of 2.45 drugs per patient were used for HP. In EDP, initial survival was 56%. There had been advanced CPR during the prehospital transport phase for the EDPs. All but two EDPs required drug management. The mean was 4.25 drugs per patient. Lidocaine and direct current defibrillation were used only rarely. Glucose was used frequently (33%) and should be considered in the list of essential resuscitation drugs. The necessity for resuscitation was most commonly associated with pulmonary diseases. These findings reflect differences between pediatric CPR and adult CPR, and suggest limitations in applying adult standards to infants and children. It is suggested that the medical community develop separate pediatric CPR courses as independent modules for those who assume responsibility for resuscitating children.

Adolescent↗

Interpretation of pediatric x-ray films by emergency department pediatricians.

This study compared the interpretation of pediatric roentgenograms by emergency department pediatricians and radiologists. Data were available from 532 of 600 children who had 564 radiographic studies during a six-week period: 217 examinations of the chest, 200 of the extremities, 74 of the skull, 35 of the abdomen, and 38 of miscellaneous structures. The emergency department pediatricians and the radiologists were in agreement in 91.1% of the cases. Among the 50 of 564 (8.9%) discordant studies, only seven (1.2%) required changes in therapy. The results attest to the accuracy of emergency department pediatricians in interpreting the usual types of films ordered in their department. However, this group specifically erred in the identification of subtle fractures and the detection of abnormalities incidental to the primary purpose for which the film was obtained. Future educational programs should address these areas of deficiency.

Adolescent↗

Fever in children with sickle cell hemoglobinopathies.

To estimate the frequency of bacteremia in children with sickle cell hemoglobinopathies (SCHs) and to evaluate the usefulness of various findings in predicting septicemia, we reviewed the charts of 153 patients with SCH who made 326 emergency department visits in a one-year period. Ninety children were febrile (greater than 38.0 degrees C). Four children, three of whom were 2 years old or younger, were bacteremic with Streptococcus pneumoniae. A temperature greater than 40 degrees C occurred in three of the four and was more common than in those who had sterile blood cultures. Two of the five patients who were 2 years old or younger and who had the combination of a WBC count of 20,000/cu mm or more and a temperature of 39.5 degrees C or higher were bacteremic. These children were significantly more likely to have bacteremia than those with lower temperatures and WBC counts.

Adolescent↗

Pediatric training in emergency medicine residency programs.

Endorsed emergency medicine (EM) residency programs were surveyed as to the nature and extent of training they provided in pediatric emergency care (PEC). In the surveys returned (82%) there were several important findings. The amount of time in PEC training was generally two months per year of training. This accounted for 16% of training time. However, the volume of pediatric patients was 25% of the overall patient population. There was wide variation in the sites of PEC training. Didactic sessions often did not cover even core topics. The training program directors were equally divided in their satisfaction with this aspect of their programs. Changes were recommended by 80% of the directors. Changes most often suggested were increasing pediatric patient exposure and obtaining PEC specialists as trainers.

Emergency Medicine↗

Pedodontics.

Explore the source record for details and available documents.

Child↗

Categorization of etiology of failure to thrive.

To develop predictors of organic vs nonorganic causes of failure to thrive, we performed a retrospective chart analysis of 82 hospitalized children. We evaluated predictors by using decision analysis. We estimated potential cost reduction that would have resulted from early categorization of these patients. Twenty-one cases had organic causes, 34 had nonorganic causes, and 19 had both organic and nonorganic causes. Physical examination proved to be a sensitive indicator of an organic component. The composite psychosocial and clinical history, together with the physical examination, accurately predicted the final category. The use of laboratory tests was primarily for confirmation. The use of these factors to identify purely nonorganic growth failure and an evaluation of such cases in an intermediate care facility could save almost $8-- per patient. In-depth psychosocial evaluation is important in all cases of failure to thrive.

Costs and Cost Analysis↗

Cellulitis: initial management.

Although Staphylococcus aureus and Streptococcus pyogenes cause the majority of cellulitis, recent studies have shown a significant role for Hemophilus influenzae in facial, and less frequently, nonfacial infections. We devised an algorithm for the initial management of cellulitis based on our previous investigations showing a correlation of this organism with fever, leukocytosis, and facial involvement. Children were divided into four groups characterized as follows: Group I - extremity, temperature less than 38.5 C; Group II - extremity, temperature greater than 38.5 C, WBC less than 15,000/cu mm; Group III - extremity, temperature greater than 38.5 C, WBC greater than 15,000/cu mm; and Group IV - facial. Forty-five children were successfully followed. There were 34 in Group I, five in Group II, one in Group III, and five in Group IV. Two children in Group IV and the only child in Group III had H influenzae, recovered form the blood (3) or a direct aspirate (1). All three were febrile, with a range of 39.5 C to 40.1 C and has an elevated white blood cell count with a range of 19,200/cu mm to 26,000/cu mm. With one exception, children with cellulitis not due to H influenzae did not have both fever and leukocytosis. This algorithm allows the clinician to identify children with H influenzae cellulitis who are at risk for septic complications while minimizing unnecessary diagnostic or therapeutic interventions.

Adolescent↗

Direct protection against acetaminophen hepatotoxicity by propylthiouracil. In vivo and in vitro studies in rats and mice.

Hepatotoxicity caused by acetaminophen can be prevented by enzyme-catalyzed conjugation of its reactive metabolite with glutathione (GSH). Since we have shown in previous studies that 6-N-propyl-2-thiouracil (PTU) can substitute for GSH as a substrate for the GSH S-transferases, we examined the possibility that PTU might also protect against acetaminophen hepatotoxicity by direct chemical interaction with the reactive metabolite of acetaminophen. In an in vitro system consisting of [(3)H]acetaminophen, liver microsomes from phenobarbital-pretreated rats, and an NADPH-generating system, we found that PTU had a dose-dependent additive effect with GSH on inhibition of acetaminophen covalent binding. PTU administration also resulted in a dose-dependent decrease in both GSH depletion and covalent binding in vivo in acetaminophen-treated mice. To examine the possible mechanisms by which PTU exerts its protective effect, we studied the action of PTU on both acetaminophen conjugation and metabolic activation. PTU had no effect upon acetaminophen pharmacokinetics in phenobarbital-pretreated rats, as examined by measuring acetaminophen concentration in bile, urine, and blood after an intraperitoneal dose, nor did it alter the total amount of polar conjugates formed. Microsomes from PTU-treated rats were unaltered in cytochrome P-450 concentrations and p-nitroanisole-O-demethylase, benzo-alpha-pyrene hydroxylase, and cytochrome c-reductase activities. Furthermore PTU did not decrease acetaminophen-GSH adduct formation in vitro, suggesting that there was no reduction in drug activation. However, in bile from [(35)S]PTU and [(3)H]acetaminophen treated rats, as well as in incubates of the two drugs with liver microsomes, a new (35)S- and (3)H-containing product could be identified. By both thin layer chromatography and high pressure liquid chromatography this new product, which co-eluted with [(3)H]acetaminophen, was separated from unreacted [(35)S]PTU. The formation of this product in vitro was a function of PTU concentration and reached a maximum of 0.06 mumol/min per mg protein at 0.5 mM PTU. In vivo, the total biliary excretion of this product over 4 h (116 nmol) equaled the net reduction in acetaminophen metabolite covalent binding in the liver of phenobarbital-pretreated rats (108 nmol). We conclude that PTU, independent of its antithyroid effect, diminishes hepatic macromolecular covalent binding of acetaminophen reactive metabolite both in vivo and in vitro, and it does so by detoxifying the reactive metabolite through direct chemical interaction in a manner similar to GSH. These observations may define the mechanism by which PTU is protective against liver injury caused by acetaminophen.

Acetaminophen↗

A multidisciplinary approach to child abuse.

The multidisciplinary approach has been utilized extensively by health care professions working with child abuse and neglect families. The multidisciplinary approach has allowed nurses, physicians, social workers, and mental health workers to collaborate in resolving complex problems. Multidisciplinary teams have taken many forms, depending on the demonstrated needs of the clinical setting. The many functions of the team may be summarized as: information-sharing, decision-making, support, and planning. Additional advantages include role clarification and many benefits for patients and families. Despite a number of well-recognized disadvantages, the multidisciplinary approach appears to have become well established in the child abuse field. Its application to other health care problems may lead to further collaboration among members of the health care professions.

Child↗