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Biomedical subjects

S Lindgren

Publications and source records attributed to S Lindgren.

At least 199 records · Page 11Linked to original sources
PubMed1982

IgM in primary biliary cirrhosis. Physicochemical and complement activating properties.

In PBC, common features beyond cholestasis and presence of mitochondrial antibodies are signs of complement activation and high levels if IgM. In order to characterize this IgM physicochemically and immunologically, we studied IgM from 15 patients with PBC in comparison with that from patients with high levels of polyclonal IgM without signs of liver disease (idiopathic hyper-IgM-emia) and normals. Agarose electrophoresis, immunofixation, gel filtration, and ultracentrifugation studies gave no evidence of any abnormal IgM populations such as complexes, aggregates, 7S IgM, or oligoclonality. However, IgM in PBC is highly cryoprecipitable, precipitable with 2.5% PEG (mol. wt. 6000) and binds to conglutinin. In addition, purified IgM from PBC patients rapidly converts complement factor C3 in fresh normal serum, mainly via the classical pathway, in contrast to IgM in the same concentration from normals or patients with idiopathic hyper-IgM-emia. IgM from PBC patients behaves like an immune complex, although it has the same molecular size and electrophoretic properties as normal IgM. No evidence of any antigen(s) bound to IgM in vivo in PBC was found in this study.

Antigen-Antibody Complex↗
PubMed1981

Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: a prospective multicenter trial of the Scandinavian Glioblastoma Study Group.

In a controlled, prospective, randomized investigation, started in 1974, 118 patients with supratentorial astrocytoma Grade III--IV were divided into three groups. Groups 1 and 2 received 45 Gy postoperatively to the whole supratentorial brain. Bleomycin in 15-mg doses and a total dose of 180 mg or placebo was given intravenously three times a week, one hour prior to radiotherapy, during weeks 1, 2, 4 and 5. Group 3 received conventional care but no radiotherapy or chemotherapy. Median survival rates of patients were 10.8 months in Groups 1 and 2, and 5.2 months in Groups 3, a statistically significant difference. With regard to performance, the patients in Group 3 deteriorated faster than patients in Groups 1 and 2. Bleomycin had no positive or negative influence on survival.

Adult↗
PubMed1981

IgM deposition in skin biopsies from patients with primary biliary cirrhosis.

Immunofluorescence studies on skin biopsies from 14 patients with primary biliary cirrhosis (PBC) showed granular papillary deposition of IgM in all. In addition, 6 patients had C3 deposition. Control patients with various other liver diseases, idiopathic high plasma levels of igM and extrahepatic cholestasis were only sporadically positive for IgM and not at all for C3. IgM deposition in dermal papillae in PBC does not merely reflect high plasma IgM levels or cholestasis but probably represents an immunochemically abnormal IgM population.

Biopsy↗
PubMed1981

[Not Available].

Explore the source record for details and available documents.

Demography↗
PubMed1980

Pharmacokinetics of dipotassium chlorazepate in patients after repeated 50 mg oral doses.

Dipotassium chlorazepate (DPC) was administered to ten patients (five males and five females), ages 18-37 years (mean 27.4), as a once daily dose of 50 mg until a steady state was reached. Plasma concentrations of the main metabolite N-desmethyldiazepam (DMD) were monitored by a high pressure liquid chromatographic (HPLC) method during the medication period and for 5 days after withdrawal of the drug. The plasma half life (t1/2), the elimination coefficient (K beta), the steady state concentration (Css), and the apparent volume of distribution (V beta), were calculated at steady state and the mean values +/- SEM were 44 +/- 5 h. 0.0184 +/- 0.0026 h(-1), 1590 +/- 163 ng/ml and 1.41 +/- 0.17 l/kg, respectively. A moderate inter-individual variability was observed. There was no tendency towards dose dependent elimination.

Adolescent↗
PubMed1978

Influence of bed rest on the pharmacokinetics of phenazone.

The pharmacokinetics of a single dose of phenazone was studied in six objects while ambulant and during bed rest for 3 days. Elimination of the drug was followed for 12 h after oral and intravenous administration. The elimination rate constant and total body clearance were significantly increased during bed rest as compared to the ambulant period, but the differences were small. The apparent volume of distribution decreased significantly. No consistent change due to bed rest was found in the rate of absorption or bioavailability of the oral dose.

Administration, Oral↗
PubMed1978

Metabolism of phenazone in man after hydrocortisone administration.

The influence of a high plasma concentration of hydrocortisone on the metabolism of phenazone in humans has been studied. Two series of experiments were carried out, Group A to demonstrate any enzyme-inducing effect of hydrocortisone, and Group B to study the immediate effect of hydrocortisone on the metabolism of phenazone. 9 subjects (Group A) received a total 250--400 mg hydrocortisone i.m. twice daily for three days and the 24-hour elimination of phenazone was studied before and afterwards. In a further 5 subjects (Group B) the elimination of phenazone was examined during administration of hydrocortisone of placebo. The elimination rate and the apparent volume of distribution of phenazone remained unchanged under both experimental conditions.

Adult↗
PubMed1977

Glial cell characteristics in bulk-prepared cell fractions from human brain tumours.

The heterogeneity of brain tumours, especially in the glioblastoma group, makes biochemical characterization of pieces of the tumours hazardous even with extensive histological controls. This study employs a technique by which separate cell populations are subsequently isolated from the tumours by means of density gradient centrifugation. Cells isolated from glial brain tumours with low density sedimentation rates show the highest levels of glial cell characteristics, i.e. S-100 content and active uptake of the neurotransmitter GABA.

Astrocytoma↗
PubMed1977

Pharmacokinetics of N-desmethyldiazepam in healthy volunteers after single daily doses of dipotassium chlorazepate.

Dipotassium chlorazepate was administered to 12 healthy volunteers (8 males and 4 females), aged 22-38 years, as a single daily dose of 20 mg for 14 days. Plasma concentrations of N-desmethyldiazepam were monitored with a gas-chromatographic method during the medication period and for 5 days after withdrawal of the drug. The plasma half-life (t1/2), the elimination coefficient (Kbeta), the concentration (Css), and the apparent volume of distribution (Vbeta) were calculated at steady state, and the mean values +/- SEM were 53 +/- 6 h, 0.0147 +/- 0.0013 h-1, 884 +/- 73 ng/ml, and 1.13 +/- 0.08 1/kg, respectively. A moderate interindividual variability was observed regarding these parameters. There was no tendency toward a biexponential elimination. A significant difference in the apparent volume of distribution was found when males and females were compared.

Adult↗