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Biomedical subjects

S Lindeberg

Publications and source records attributed to S Lindeberg.

43 records · Page 3Linked to original sources
PubMed1987

A management programme for Rh alloimmunization during pregnancy.

A management programme for the control and treatment of Rh0 (D) immunized during pregnancy is presented. A total of 34,650 births were registered during a 4.5 year period and included 63 D positive newborns to D-immunized mothers. The outcome of all infants has been evaluated according to the severity of the haemolytic disease. Exchange transfusion was unnecessary in 43 mild cases (68.3%). Fourteen infants (22.2%) required exchange transfusion, and in 6 severe cases (9.5%) maternal plasma exchange and exchange transfusion was performed. No detrimental effects or deaths occurred among the infants suffering from Rh haemolytic disease. We recommend that the frequency and volume of plasma exchange therapy should be individually adjusted to suit each patient and the effect monitored regularly through maternal anti-D levels using a sensitive quantitative technique.

Amniotic Fluid↗
PubMed1985

A prospective controlled trial of metoprolol-hydralazine treatment in hypertension during pregnancy.

In an open, controlled trial, treatment with a combination of metoprolol and hydralazine was compared with non-pharmacological management of mild and moderate hypertension in pregnancy. One hundred and sixty-one women participated in the study. The drug-treated group showed significantly better blood pressure control than the group not given antihypertensives. Induction of labor before term, because of maternal or fetal complications, was somewhat more frequent in the control group. Nine women in the treatment group and 5 in the control group developed albuminuria. Three infants in the drug-treated group died perinatally, and one in the control group. The outcome for the newborns was similar in both groups concerning birth weight, head circumference and Apgar score and in the frequencies of respiratory distress, bradycardia and hypoglycemia. The better blood pressure control achieved with these drugs makes it possible to treat the patient at home and reduce the risk of emergency delivery, but treatment does not seem to be mandatory for a good outcome of the pregnancy in cases of mild and moderate hypertension during pregnancy.

Adult↗
PubMed1984

Blood lactate accumulation during arm exercise in world class kayak paddlers and strength trained athletes.

Blood lactate accumulation was studied during progressive arm exercise in male and female world class kayak paddlers (K male, K female, n = 11), weight-/power-lifters (WL/PL, n = 6), bodybuilders (BB, n = 8) and non-athletes (NA, n = 6). The heavy resistance trained athletes exhibited greater upper-body muscle volume than the other subject groups. During low submaximal exercise intensities, blood lactate concentrations were significantly lower both in male and female kayakers compared with WL/PL, BB, and NA. Mean values at 120 W were 1.9 (K male), 2.1 (K female), 4.8 (WL/PL), 4.5 (BB), and 5.1 (NA) mmol X l-1. At higher power outputs the difference between females and non-kayakers diminished, while the difference between K male and all other groups increased. Exercise tolerance was greatest in K male and was equal among the other groups. Our results suggest that factors other than the muscle mass per se involved in exercise are responsible for the blood lactate response during this kind of work. Moreover, the physiological response observed in kayakers probably represents the upper limit of man's ability to perform continuous progressive arm-cranking exercise.

Adult↗
PubMed1984

Disposition of the adrenergic blocker metoprolol in the late-pregnant woman, the amniotic fluid, the cord blood and the neonate.

Pharmacokinetic studies on the concentration of the beta 1-blocker metoprolol have been performed in maternal plasma, amniotic fluid, breast milk and the plasma of the newborn. The concentration of metoprolol in maternal plasma exceeded that in the amniotic fluid initially , but not later on. The quotient between the metoprolol concentration in the maternal venous blood and the mixed cord blood at the time of parturition is at about 1. In the maternal plasma the metoprolol concentration decreases rapidly after the latest dose, probably because of an increased clearance rate. Blood levels of metoprolol during the first postnatal hours increase almost fourfold and are generally followed by a decrease over the next 15 hours. Active metabolites of metoprolol (alfa-OH-metoprolol and 0-demethyl-metoprolol) are found in the urine of the newborn. The breast milk concentration of metoprolol is three times as high as in the maternal plasma but the suckling newborn will only show very low or unmeasurable plasma levels between consecutive breast feeding periods, in the majority of cases.

Amniotic Fluid↗
PubMed1983

Disposition of the adrenergic blocker metoprolol in the late pregnant women, the amniotic fluid, the cord blood and the neonate.

Pharmacokinetic studies of the concentration of the beta 1-blocker metoprolol have been performed in maternal plasma, amniotic fluid, breast milk and the plasma of the newborn. The concentration of metoprolol in maternal plasma exceeds that in the amniotic fluid initially but not later on. The quotient between the metoprolol concentration in the venous maternal blood and the mixed cord blood at the time of delivery is at about 1. In the maternal plasma the metoprolol concentration will decline in a rapid way after the latest dose probably because of an increased clearance. Blood levels of metoprolol during the first postnatal hours will increase almost fourfold and are generally followed by a decrease over the next 15 hours. Active metabolites of metoprolol (alfa-OH-metoprolol and O-demethyl-metoprolol) are found in the urine of the newborn. The breast milk concentration of metoprolol is 3 times higher than in the maternal milk but the sucking newborn will only show very low or unmeasurable plasma levels between consecutive breast feeding periods in the majority of cases.

Adrenergic beta-Antagonists↗