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Biomedical subjects

S Lewis

Publications and source records attributed to S Lewis.

At least 343 records · Page 19Linked to original sources
PubMed1990

Visual analogue measurement of pain.

Two separate studies were carried out to determine if three visual analogue scales for various feelings including pain could be marked consistently by patients, without reference to previously completed scales. Sixty patients undergoing extraction of their lower third molars had measurements of acute preoperative anxiety, expected postoperative pain and postoperative perceived pain three times in quick succession. There was no significant difference between the three measurements for any of the feelings. Although a correlation was detected between expected pain and preoperative anxiety, there was no meaningful relationship between perceived postoperative pain and expected pain or preoperative anxiety. Eighty patients suffering from a wide range of chronic painful states completed three identical scales for pain, anxiety, depression and mood during their first visit. These measurements were repeated at a later time following a treatment, with the addition of a visual analogue scale for pain relief. Mean scores for anxiety, mood and pain relief were consistent, but mean pain scores were more variable. There was a very close correlation between any two feelings expressed on these visual analogue scales during both the initial and second visits. Litigation or social problems were not associated with increased pain scores.

Adolescent↗
PubMed1990

The radiographic demonstration of the pterygopalatine fossa and canal.

This article considers the importance of the pterygopalatine fossa and canal and how it might be demonstrated on plain radiographs. Given the possibility that certain lesions in this region may go undetected in standard projections, the value of keeping 'reject' lateral radiographs is considered.

Humans↗
PubMed1989

Childhood cancer survivors' knowledge of their diagnosis and treatment.

PURPOSE: To determine what factors correlated with the failure of the survivors of childhood cancer to acknowledge their diagnosis. STUDY DESIGN: A follow-up interview with 1928 adults who survived childhood cancer to evaluate the late effects of cancer and its treatment. Cancer was diagnosed in these survivors between 1945 and 1974 before they reached age 20: subjects had to have survived for at least 5 years and to have reached age 21. RESULTS: Fourteen percent of the survivors of malignancies at sites other than the central nervous system said that they had not had cancer. This proportion differed according to the survivors' race, the type of tumor and its treatment, the level of their father's education, the year of diagnosis, and the center where the tumor was diagnosed. Among survivors who knew that they had cancer previously, however, most (81%) correctly identified the type of treatment they had received. CONCLUSIONS: Physicians should be aware that a substantial proportion of long-term survivors of childhood cancer may not reveal their past history of cancer and its treatment, and possible clues to the cause of the presenting condition may thus be missed.

Adult↗
PubMed1989

Vocational training. A year of opportunity.

Vocational training, a stepping stone or a wasted year? The response speaks for itself. The need was perceived for some sort of cushioning between under-graduate protection and the harsh realities of a working day in general practice. The support for the scheme from dental students was overwhelming. The worried conversations of some final year students, discussing their futures, should change dramatically. The new graduate can now face the challenges of his first steps in the real world with more confidence and security. Yet, argues Simon Lewis, vocational training offers much more than just a stepping-stone.

Education, Dental↗
PubMed1989

Coexpression of myosin isoforms in muscle of patients with neurogenic disease.

Three well-characterized antimyosin heavy chain monoclonal antibodies (McAbs) were used as immunocytochemical reagents to study myosin isoform expression in relationship to adenosine triphosphatase (ATPase) defined fiber types in human muscle. The biopsy specimens were from patients with neurogenic muscle disease whose muscle exhibited fiber type grouping and group atrophy. The use of McAbs revealed heretofore unrecognized coexpression of multiple myosin isoforms in selected fibers in the pathologic samples which was not apparent with ATPase reactions and not present in normal muscle. The fibers containing multiple myosin isoforms were probably undergoing neurally directed fiber type transformation. Furthermore, a small population of fibers in neurogenic specimens expressed a "prenatal" myosin signifying the presence of regenerating fibers. We also demonstrated immunocytochemical evidence of the persistence of adult slow myosin in denervated mature human skeletal muscle despite the reputed necessity of innervation for maintenance of expression of this myosin isoform proffered by others.

Biopsy↗
PubMed1989

Single tooth implants.

Explore the source record for details and available documents.

Dental Implantation, Endosseous↗
PubMed1989

The restoration of improperly inclined osseointegrated implants.

Improper implant angulation is one of the most difficult problems to overcome in the fabrication of implant-supported and implant-retained restorations. Several techniques using the "UCLA" abutment have been developed to solve these problems. The creation of large screw-access holes for moderate angulation and the fabrication of telescopic copings and overlay castings for severe angulation problems are discussed.

Dental Implantation, Endosseous↗
PubMed1989

Quadriceps strength training using two forms of bilateral exercise.

The purpose of this study was to determine the effectiveness of quadriceps strength training in 15 women using bilateral constant resistance computerized exercise equipment that enabled only concentric contractions. To facilitate this investigation, data from an experimental control group (n = 14), using bilateral variable resistance exercise equipment which enables both concentric and eccentric muscle contractions, and a nonexercise control group (n = 17) were incorporated into the study design. Through a random selection process, subjects were assigned to one of three groups that participated in this 10-week study. Analysis, including univariate and multivariate statistical techniques, revealed no significant changes in strength between the two experimental groups. However, compared with the nonexercise group, there were significant increases in strength in the experimental exercise groups; yet, these increases were significant in both groups only on the right legs. In addition, the development of transient knee pain in two subjects engaged in both concentric and eccentric exercise training required their removal from the study. This finding, in concert with previous experimental evidence of an association between eccentric exercise and the development of transient pain, must be integrated into future studies. Results suggest that further investigation is necessary to reveal the neurologic or biomechanical factors which may result in unequal training stimuli to the limbs with bilateral strength training on various types of equipment.

Adult↗
PubMed1988

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

Pre-B and pre-T cell lines from mutant mice with severe combined immune deficiency (scid mice) were transfected with plasmids that contained recombination signal sequences of antigen receptor gene elements (V, D, and J). Recovered plasmids were tested for possible recombination of signal sequences and/or the adjacent (coding) sequences. Signal ends were joined, but recombination was abnormal in that half of the recombinants had lost nucleotides from one or both signals. Coding ends were not joined at all in either deletional or inversional V(D)J recombination reactions. However, coding ends were able to participate in alternative reactions. The failure of coding joint formation in scid pre-B and pre-T cells appears sufficient to explain the absence of immunoglobulin or T cell receptor production in scid mice.

Animals↗
PubMed1988

Pulmonary interstitial emphysema: selective bronchial occlusion with a Swan-Ganz catheter.

A 26 week preterm infant ventilated for hyaline membrane disease developed severe pulmonary interstitial emphysema with extensive right sided bullous formation, mediastinal shift, and subsequent left sided atelectasis. A paediatric Swan-Ganz catheter was used for selective bronchial occlusion with dramatic improvement in the infant's clinical condition and radiographic findings.

Catheterization, Swan-Ganz↗
PubMed1988

Reduced therapy for Wilms' tumor: analysis of treatment results from a single institution.

From 1968 to 1986, 192 patients from 0 to 17 years of age were enrolled in three consecutive protocol-controlled studies of Wilms' tumor at St Jude Children's Research Hospital. Tumors were completely excised at the time of diagnosis whenever possible, and patients were subsequently treated with chemotherapy and radiotherapy according to the initial extent of disease. All patients received dactinomycin and vincristine, with doxorubicin added to the regimens in studies 2 and 3. Chemotherapy was extended to 18 months in study 2 (n = 53), but was limited to 12 months for most patients in study 3 (n = 107). In the third study, radiation was eliminated altogether for patients with stage I or II tumors and was reduced to 12 Gy for those with more advanced disease. Intensification of chemotherapy in study 2 improved the 5-year relapse-free survival rate over that in study 1 (82% v 52%), but the accompanying increase in toxicity was considered unacceptable. Comparison of 2-year relapse-free survival rates in studies 2 and 3 indicated that the reduction of therapy in the latter trial did not jeopardize disease control: 88% v 86% for patients with stage II or III disease, favorable histology; 75% v 57% for the same stages, unfavorable histology; and 57% v 61% for stage IV patients. At least 80% of all patients enrolled in study 3 will be long-term survivors. We conclude that rescheduling of effective antitumor drugs and eliminating or reducing radiotherapy are feasible alternatives in the treatment of Wilms' tumor with favorable histologic features.

Adolescent↗
PubMed1988

Patent ductus arteriosus in the elderly.

Patent ductus arteriosus presenting in an elderly patient is unusual. This report describes the oldest patient (72 years) to undergo successful surgical interruption of a patent ductus arteriosus with a unique clinical presentation of typical angina pectoris with normal coronary anatomy. A possible pathophysiologic mechanism for this previously unreported presenting symptom is proposed. The natural history of patent ductus arteriosus and the role of surgery in the elderly patient are discussed.

Aged↗