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Biomedical subjects

S Lenhart

Publications and source records attributed to S Lenhart.

4 recordsLinked to original sources
PubMed2003

Optimal control of the transient behavior of coupled solid-state lasers.

We apply optimal control theory to substantially reduce transient times for transitions between in-phase and out-of-phase states in coupled solid-state lasers. The control is a time-varying optical field that is injected into the cavities of each laser. We have analytically derived the optimal control and numerically solved the optimality system. Numerical simulations indicate that transient times can be significantly reduced upon increasing the injection strength very briefly.

Journal Article↗
PubMed1997

Optimal control of the chemotherapy of HIV.

Using an existing ordinary differential equation model which describes the interaction of the immune system with the human immunodeficiency virus (HIV), we introduce chemotherapy in an early treatment setting through a dynamic treatment and then solve for an optimal chemotherapy strategy. The control represents the percentage of effect the chemotherapy has on the viral production. Using an objective function based on a combination of maximizing benefits based on T cell counts and minimizing the systemic cost of chemotherapy (based on high drug dose/strength), we solve for the optimal control in the optimality system composed of four ordinary differential equations and four adjoint ordinary differential equations.

Anti-HIV Agents↗
PubMedDate not supplied

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Employment↗