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Biomedical subjects

S Lehmann

Publications and source records attributed to S Lehmann.

99 records · Page 6Linked to original sources
PubMedDate not supplied

Partial calcanectomy in the treatment of chronic heel ulceration.

Chronic decubitus ulceration of the heels is a common condition encountered by podiatric physicians, especially in diabetic patients. Very often these ulcerations can progress to osteomyelitis of the calcaneus. Many times, this in turn leads to a below-the-knee amputation. A partial calcanectomy is a viable alternative to below-the-knee amputation. A more functional limb both mechanically and cosmetically is achieved, and the morbidity and mortality associated with the calcanectomy is less than with a below-the-knee amputation. A brief overview of the history and outcomes associated with this procedure is outlined and a case utilizing a partial calcanectomy is presented.

Calcaneus↗
PubMedDate not supplied

[Detection and prevalence of verotoxin-producing Escherichia coli (VTEC) in raw sausage].

We investigated 158 samples of shortly ripened raw sausages bought in supermarkets of Dessau within 4 month. In 14 (8.8%) samples Verotoxin-producing E. coli were detected. 13 VT-positive samples were found in the group of easily spread raw sausages. The 14 isolates belonged to 6 different O-serotypes. 4 VT1-, 8 VT2- and 2 VT1/VT2-producers were found. 4 isolates belonged to serogroups which were already described in WHO tables and associated with EHEC infections in human beings. One strain of serogroup O22: H8, isolated from a "Teewurst", possessed the complete virulence gene combination of EHEC (eae, hlyA, stx). The detection procedure, already successfully used for detection and isolation of VTEC from raw milk, soft cheese and raw minced beef showed a sensitivity of approximately 10 CfU/25 g of raw sausages. It has to be considered that VTEC are frequently (8.8%) present in shortly ripened raw sausages. The group of easily spread raw sausages has a higher VTEC-contamination rate than firm raw sausages. Raw sausages, especially easy to spread types, belong to the risk foods for EHEC-infections in human beings.

Animals↗
PubMedDate not supplied

Improvement in immune function in ICU patients by enteral nutrition supplemented with arginine, RNA, and menhaden oil is independent of nitrogen balance.

Hypermetabolism and multiple organ failure syndrome (MOFS) after trauma, surgery, or sepsis is associated with accelerated catabolism, the rapid onset of malnutrition, and immune system failure. Current nutritional support, enteral or parenteral, can achieve an acceptable nutritional response but appears unable to improve immune function. Nutrients such as arginine, refined menhaden oil, and RNA have been found to have immune-stimulating properties. This randomized blind prospective trial compared two nutritionally complete enteral formulas, one supplemented with arginine, menhaden oil, and RNA, on the disease-specific effects of anergy and suppression of in vitro tests of immune function in intensive-care patients and the nutritional outcome of nitrogen balance. After 7-10 days of enteral nutrition in patients with persistent sepsis syndrome, both formulas were associated with the achievement of net nitrogen retention and improved visceral protein status but with nonresolution of anergy. However, the supplemented formula was associated with marked stimulation of in vitro lymphocyte proliferative responses and a significant reduction in 3-methylhistidine excretion. Six and 12-mo follow-up data demonstrated no long-term effects. Nutrients targeted to effect the disease-induced in vitro suppression of immune function in MOFS appear to achieve that end independent of the nutritional outcome of nitrogen balance and without adverse clinical outcome.

Adult↗
PubMedDate not supplied

Immune function and nutrition. The clinical role of the intravenous nurse.

Protein-calorie malnutrition is considered to be one of the most frequent causes of immunosuppression in the world today. Malnutrition can affect the functioning of T cells, B cells, and macrophages, the principle players involved in cell-mediated and humoral immunity. Immune function is measured by the total lymphocyte count and delayed cutaneous hypersensitivity reaction. Nutritional markers include serum albumin and transferrin levels. Immune function is affected by protein (especially arginine intake); the balance between omega-6 and omega-3 fatty acid intake; and adequate amounts of vitamins A, E, and C, and the minerals zinc and iron. A deficiency of these nutrients puts the patient at increased risk of infection. Non-nutritional factors can influence immune functioning as well. The intravenous nurse must review the patients history, physical examination, and laboratory values to achieve a global view of the patient's immune function and nutrition status in order to be able to develop an appropriate care plan based on this nursing diagnosis: potential for infection secondary to alteration in immune function.

Antibody Formation↗