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Biomedical subjects

S Landas

Publications and source records attributed to S Landas.

23 records · Page 2Linked to original sources

Uptake of prolactin from cerebrospinal fluid in rat brain.

The fate of prolactin in the cerebrospinal fluid was studied by the use of fluorescein labelled prolactin. The distribution was compared to the immunocytochemical distribution of endogenous prolactin. High intensity fluorescence was found in the ependyma of the area postrema, rostral dorsolateral cerebral aqueduct close to the subcommissural organ, and in some cells of the floor of the cerebral aqueduct. This distribution was not seen when excess unlabelled prolactin was injected. The results suggest prolactin uptake from CSF at specific sites which correspond to sites of localization of immunoreactive prolactin.

Animals↗

Visualization of specific angiotensin II binding sites in the brain by fluorescent microscopy.

The organum vasculosum of the lamina terminalis has been implicated as the site of receptors mediating central responses of angiotensin II. Up to now, this had been based on indirect evidence, but direct visualization of angiotensin II at its site of action has now been achieved by the use of a biologically active fluorescent angiotensin II agonist. The ventricular surface of the organum vasculosum lamina terminalis showed intense fluorescence, which was virtually eliminated by an excess of unlabeled angiotensin II.

Angiotensin II↗

Six-month follow-up after thermal balloon angioplasty in canine iliac arteries.

We performed thermal balloon angioplasty in 10 iliac arteries in 5 mongrel dogs. By perfusing a modified angioplasty balloon with hot (100 degrees C) saline, a mean balloon temperature of 84 degrees C was obtained. Angiographic and histologic follow-up at 6 months revealed no thrombosis or aneurysm formation but it did reveal fibrotic transformation of the media. Initial overdilatation was maintained in 9 of 10 arteries. We conclude that medial sclerosis induced by thermal balloon angioplasty does not result in aneurysm or thrombosis in dogs.

Aneurysm↗