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Biomedical subjects

S Landahl

Publications and source records attributed to S Landahl.

67 records · Page 4Linked to original sources
PubMed1982

Metabolic effects of digitalis.

In a study of two representative population samples of 70-year-olds, one of which was followed up at 75 years of age, digitalis treatment was associated with oestrogen-like metabolic effects, indicated by changes in the composition of the plasma phospholipid fraction. Digitalis treatment, at least at these ages, is related to metabolic effects even in patients lacking more obvious clinical signs such as gynaecomastia. The results suggest that digitalis treatment may have other oestrogenic effects, e.g. on the water and sodium balance, counteracting the cardiotropic effects of this drug.

Blood Pressure↗
PubMed1981

Blood components in a 70-year-old population.

The concentrations of many blood components change with age, and the aim of the present study was to determine, at the age of 70, the concentrations of blood components commonly used in clinical routine, and to examine how the exclusion of probands with disease influenced their distribution. In connection with a longitudinal population study "70-year-old people in Göteborg" 30 blood components have been analyzed in a representative sample of 973 70-year-old men and women. 29% of the probands were found to be without definable disease or treatment for presumed disease. Concentrations of 13 components were found to have a gaussian distribution which was not altered after the exclusion of probands with definable disease. Three components were asymmetrically distributed in the total material and showed a normal distribution with decreased concentrations at the 97.8% level after the exclusion of probands with definable disease. The remaining 14 components had asymmetrically distributed concentrations both in the total material and in the subjects without definable diseases. For blood components with normally distributed concentrations in the probands without definable disease, acceptable reference values could be obtained without exclusion of sick probands. For asymmetrically distributed blood components the concentration at the 97.8% level usually decreased more, after exclusion of probands with definable disease, the more asymmetric the distribution was. Examples of reference intervals are (men and women) B-Hb: 130--171 and 119--159 g/l, S-iron: 6--29 and 5--28 mumol/l, S-creatinine: 52--110 and 44--100 mumol/l, P-cholesterol: 3.6--9.2 and 4.6--9.7 mmol/l, P-B12: 50--350 and 65--390 pmol/l, B-ESR: 1--30 and 2--34 mm/h and B-glucose: 4.0--7.2 and 4.0--6.8 mmol/l.

Age Factors↗
PubMed1980

Dyspnea in 70-year-old people.

In the population study "70-year-old people in Göteborg" 45.5% of the probands were found to have an increased exertional dyspnea or to be short of breath at the medical examination. We have found it interesting to estimate to what extent a subjective experience of dyspnea at the age of 70 is related to disease and whether it is available for treatment. Out of these probands, 64% of the males and 48% of the females suffered from cardiac failure or pulmonary disease, compared to 48% of males, and 24% of females without dyspnea. Among dyspnoic probands without cardiac failure and pulmonary disease, ischemic heart disease was significantly more common than in probands without dyspnea. Probands with dyspnea but without cardiopulmonary disease felt less healthy and were more tired than others, although an objective health screening showed no difference between the two groups. They also had a significantly lower peak flow rate. A dyspnea that was not statistically related to disease was found in 30% of the males and 43% of the females. During a 5-year follow-up there was no statistically significant difference in mortality between dyspnoic probands without cardiopulmonary disease and others.

Aged↗
PubMed1980

Prevalence and treatment of hypomagnesemia in the elderly studies in a representative in 70-year-old population and in geriatric patients.

Within in the framework of the longitudinal gerontological and geriatric population study in Göteborg, Sweden, S-Magnesium (S-Mg) was examined in 55 70-year-old males and 55 70-year-old females with a as many probands without diuretic treatment. Probands with diuretic treatment had lower S-Mg than others (p smaller than 0.001). Females had higher S-Mg values than males both in those with (p smaller than 0.05) and without (p smaller than 0.01) diuretic treatment. Sixteen per cent of the males and 7 per cent of the females with diuretics had S-Mg below 0.7 mmol/l compared to none in those without. Out of 161 geriatric inpatients those 50 (17 males and 33 females) with the lowest S-Mg values took part in a double blind comparison between supplementation with a magnesium chloride and a placebo solution during three weeks. The daily dose was 12.5 mmol MgCl2. The tolerance of the solution was tested in 30 young healthy individuals and was found to be good. During treatment with magnesium chloride, S-Mg increased 0.09 plus or minus 0.08 mmol/l (p smaller than 0.001) and during treatment with placebo 0.08 plus or minus 0.09 mmol/l (p smaller than 0.01). The difference between the two groups was not significant. S-potassium, however, increased significantly more in the patients treated with magnesium chloride (p smaller than 0.01). The increase in the treatment group was 0.31 plus or minus 0.32 mmol/l compared to a decrease of 0.02 plus or minus 0.42 mmol/l in the placebo group.

Adult↗
PubMed1977

Digitalis therapy in a 70-year-old population.

In the population study "70-year-old people in Gothenburg" 14% of the probands were found to be undergoing treatment with digitalis, 6% with digoxin, 6% with digitoxin and 2% with other glycosides. A comparison between results of the interview method and those of S-digoxin analyses indicates that the interview method was acceptable. As far as can be judged from S-digoxin analyses, only about 60% of the treated patients were on a dosage considered to be effective and free from obvious risks of side-effects. Out of the 130 70-year-olds who were on digitalis treatment, 37% had obvious symptoms of heart disease requiring such treatment, 34% lacked symptoms of arrhythmia and/or congestive failure but had heart volumes larger than those used as reference values in younger age groups, and 29% had no symptoms indicating digitalis treatment. At least 13% of the population had indications for digitalis therapy and about 75% of those apparently needing digitalis were on such treatment. Thus both over- and underdiagnosis of heart disease requiring digitalis therapy were common in this age group.

Age Factors↗