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S Lancaster

Publications and source records attributed to S Lancaster.

21 records · Page 2Linked to original sources

Subtalar dislocations: a prognosticating classification.

A review of the literature and analysis of eight cases of subtalar dislocations was undertaken to correlate our experience with others and to determine a classification for prognostication. Our findings corresponded with those found by others. A 75% incidence of associated injuries was present in our series and these represented a continuum of varying degrees of complication. A new system was devised whereby increasing severity of associated injuries correlated with increasing rate of complications, including loss of motion, arthritis, pain and avascular necrosis. Dislocations were classified according to: no associated injuries, those with soft tissue injuries, extra-articular fractures, intra-articular fractures and those prone to development of avascular necrosis, ie, open dislocations and fractures of the body of the talus. It was found that associated fractures increased the immobilization period as well as the incidence of complications. Intra-articular fractures have demonstrated increased rates of arthroses in the subtalar joint. Avascular necrosis, an infrequent but devastating complication, is primarily associated with open dislocations and dislocations with concomitant fractures of the body of the talus. Our series had two open subtalar dislocations, neither of which developed avascular necrosis.

Adolescent↗

Kinetic and morphometric responses of heterogeneous populations of NMU-induced rat mammary tumor cells to hormone and antipolyamine therapy in vivo.

The present experiments were designed to evaluate in vivo the differential sensitivity of tumor cell subpopulations to hormone and polyamine manipulations using the hormone-responsive N-nitrosomethyl-urea (NMU)-induced rat mammary tumor. NMU tumor bearing rats were randomly assigned to control, ovariectomy, alpha-difluoromethyl-ornithine (DFMO) administration (an inhibitor of polyamine biosynthesis), or combination treatment, and were sacrificed on day 2, 4, or 7. The proportion of different cells was estimated by morphometric analysis and their replicative activities by [3H]-thymidine autoradiography. In tumors of intact rats, the fractions of glandular, myoepithelial, and non-epithelial cells were 85.3 +/- 2.2%, 4.7 +/- 0.7%, and 9.9 +/- 1.9%, respectively. Ovariectomy induced a similar time-dependent decline in the labelling indices of each cell type (from 5% to 1%). It also decreased the fraction of glandular cells (74.9 +/- 4.5%), while increasing the fraction of myoepithelial (8.6 +/- 1.9%) and non-epithelial (16.3 +/- 3.2%) cells. DFMO exerted similar but more modest effects. DFMO-induced tumor regression was also inferior to that observed with ovariectomy. Combined ovariectomy and DFMO induced a faster and greater suppression of all labelling indices than the individual treatments, even though tumor regression was not superior to that produced by ovariectomy alone. Combination treatment also produced more profound morphologic changes, reducing the fraction of glandular cells to 64.4 +/- 3.9% and increasing that of non-epithelial cells to 26.6 +/- 4.4%. Ovariectomy and DFMO reduced height but not width of glandular cells, resulting in a modest decrease in cell volume. The combination treatment, however, significantly suppressed all three parameters.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗