ELECTRON MICROSCOPIC INVESTIGATION OF PHAGOCYTOSIS OF MYELIN IN AN EXPERIMENTAL LEUKOENCEPHALOPATHY.
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Biomedical subjects
Publications and source records attributed to S LEVINE.
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The hyperacute form of allergic encephalomyelitis is characterized by its short incubation period, 100 percent incidence, overwhelming severity, and high mortality and by the massive quantities of polymorphonuclear neutrophils, fibrin, and edema fluid which infiltrate the central nervous system. The hyperacute form has been produced with the aid of aqueous pertussis vaccine as an adjuvant. This is the first reproducible laboratory model for human acute necrotizing hemorrhagic encephalopathy.
The injection of 100 microg of estradiol benzoate into female rats 96 hours after birth abolished sexual receptivity in adulthood, even with estrogen and progesterone replacement after ovariectomy. The administration of testosterone propionate to these animals in adulthood elicited the full pattern of male sexual behavior. The same dose of estrogen given to male rats 96 hours after birth produced adults which were unable to achieve intromission, although they mounted as frequently as normal animals. Testosterone replacement after castration in adulthood reproduced this abnormal behavior.