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Biomedical subjects

S L Shih

Publications and source records attributed to S L Shih.

At least 37 records · Page 2Linked to original sources
PubMed1994

Acute segmental obstructing enteritis in children.

We studied a group of 15 children with acute segmental enteritis associated with intestinal obstruction. The disease is characterized by fever, leukocytosis, copious bilious vomiting, and severe abdominal pain with signs of intestinal obstruction. Exploration revealed varying degrees of segmental ischemic change in the small bowel, but surgery seemed to be unnecessary in most cases. Antibiotics were effective in nonoperative cases. The clinical illness lasted 10-14 days. The disease was self-limited, and no mortality was found in our series. To our knowledge, this is the first report of this disease entity in Chinese children.

Abdominal Pain↗
PubMed1993

Cranial computed tomography in children with acute lymphoblastic leukemia after prophylactic treatment with cranial radiation therapy and intrathecal methotrexate.

BACKGROUND AND METHODS: Thirty-one children with acute lymphoblastic leukemia (ALL) who had received cranial radiation therapy (CrRT) and five concomitant doses of intrathecal methotrexate (IT MTX) for central nervous system prophylaxis (CNSP) and who had an event-free survival exceeding 5 years had cranial computed tomography (Cr CT) examination. The fractional dose for 21 of them was 1.5 Gy. The interval between the completion of CNSP and the time of Cr CT ranged from 5 to 8.5 years, with a median of 5 years 2 months. RESULTS: Unlike the previous reports in the literature that 9-77% of children with ALL who had received Cr RT 18 Gy and IT MTX as CNSP had CT scan abnormalities, in this study no patient had CT scan abnormalities. CONCLUSIONS: Our results might be attributable to the fractional dose of Cr RT being adequate, the IT chemotherapy being suitable, and the systemic chemotherapy not being intensive.

Brain↗
PubMed1993

Neurofibroma: an unusual presentation.

We report neurofibroma discovered incidentally in a woman who suffered trauma to her cheek. The lesion was manifest on CT as a haematoma within a parotid tumour.

Adult↗
PubMed1993

Computed tomography of spontaneous intracranial haemorrhage due to haemostatic disorders in children.

Intracranial haemorrhage is a serious problem in haemostatic disorders in children. Intracranial bleeding is sometimes more marked than suspected clinically. Computed tomography (CT) permits accurate, sensitive diagnosis of intracranial haemorrhage. We report 13 patients; 3 patients with hypoprothrombinaemia, 4 patients with thrombocytopenia or platelet dysfunction and 6 with haemophilia A, B or Von-Willebrand's disease. One patient with hypoprothrombinaemia had a subarachnoid hemorrhage (SAH), one a subdural haematoma (SDH) and the third a combination of SAH, SDH and intracerebral haematoma (ICH). One patient with thrombocytopenia or platelet dysfunction had a SDH, while the others had ICH. In the six patients with haemophilia A, B or Von-Willebrand's disease, there were four examples of ICH, five of SAH and six of SDH. A neurosurgical procedure was performed in only one patient. Three children died of serious intracranial complications with uncal herniation.

Adolescent↗
PubMed1992

Unusual causes of obstructive jaundice in children: diagnosis on CT.

Three cases are presented with unusual causes of obstructive jaundice diagnosed on abdominal CT in children under the age of 15 years. All the cases were initially examined by ultrasound which was inconclusive. CT studies were subsequently performed were diagnostic. These cases included hepatocellular carcinoma, a common bile duct web and duodenal hematoma. The first two cases were surgically confirmed, while the third case was proved by clinical follow-up.

Adolescent↗
PubMed1990

Extralobar pulmonary sequestration of the left retroperitoneum.

This paper presents an extralobar pulmonary sequestration in the left retroperitoneum in an eight year old girl. The clinical and diagnostic features included abdominal pain, an abdominal mass, elevated VMA, and radiological manifestations simulating a left adrenal mass. A laparatomy was performed. Extralobar pulmonary sequestration of the left retroperitoneum is fairly uncommon. An eight year old girl was admitted with abdominal pain, elevated urinary VMA and an abdominal mass. The radiological manifestations simulated a left adrenal mass. At surgery an extralobar pulmonary sequestration was detected.

Bronchopulmonary Sequestration↗
PubMed1989

Aneurysmal dilatation of the portal vein.

In the following study, a case involving an aneurysmal dilatation of the portal vein is reported. The 5-year-old boy had a 2 month history of intermittent abdominal pain. A segmental dilatation of the portal vein was noted in the sonographic examination. The portal vein aneurysm diagnosis was later confirmed by superior mesenteric angiography and computed tomography. In our review of the literature, less than 30 cases of portal venous aneurysm have been reported. To our knowledge, this is the youngest case with such an anomaly.

Arteriovenous Fistula↗
PubMed1989

[Parathyroid adenoma associated with bilateral renal calculi. A case report].

Renal calculi is an uncommon clinical presentation of parathyroid adenoma today. Only 17% of parathyroid adenoma has renal calculi in Levin's report. The association of parathyroid adenoma is often overlooked in the patients of renal calculi. We report a case whose clinical presentation is renal calculi with renal colic Parathyroid adenoma was not discovered until the second admission. The patient's clinical presentation improved after parathyroidectomy. We report this case to remind the clinical physician regarding the possibility of coexistence of parathyroid adenoma in patients of renal calculi. Excision of the parathyroid adenoma is the only treatment for these patients.

Adenoma↗
PubMedDate not supplied

Human ARX gene: genomic characterization and expression.

Arx is a homeobox-containing gene with a high degree of sequence similarity between mouse and zebrafish. Arx is expressed in the forebrain and floor plate of the developing central nervous systems of these vertebrates and in the presumptive cortex of fetal mice. Our goal was to identify genes in Xp22.1-p21.3 involved in human neuronal development. Our in silico search for candidate genes noted that annotation of a human Xp22 PAC (RPCI1-258N20) sequence (GenBank Accession No. AC002504) identified putative exons consistent with an Arx homologue in Xp22. Northern blot analysis showed that a 3.3kb human ARX transcript was expressed at high levels in fetal brain. A 5.9kb transcript was expressed in adult heart, skeletal muscle, and liver with very faint expression in other adult tissues, including brain. In situ hybridization of ARX in human fetal brain sections at various developmental stages showed the highest expression in neuronal precursors in the germinal matrix of the ganglionic eminence and in the ventricular zone of the telencephalon. Expression was also observed in the hippocampus, cingulate, subventricular zone, cortical plate, caudate nucleus, and putamen. The expression pattern suggests that ARX is involved in the differentiation and maintenance of specific neuronal cell types in the human central nervous system. We also mapped the murine Arx gene to the mouse genome using a mouse/hamster radiation hybrid panel and showed that Arx and ARX are orthologues. Therefore, investigations in model vertebrates may provide insight into the role of ARX in development. The recent identification of ARX mutations in patients with various forms of mental retardation make such studies in model organisms even more compelling.

Amino Acid Sequence↗
PubMedDate not supplied

Congenital rickets--a patient report.

We present a premature newborn with congenital rickets, born to a mother with untreated chronic renal insufficiency. X-ray films showed blurred metaphyseal ends and decreased bone density in the femurs and ribs. With treatment including calcium, phosphate, and vitamin D, her rickets healed and she grew normally.

Adult↗
PubMedDate not supplied

Is IVP necessary in children with urinary tract infection?

A prospective study was conducted to determine the role of intravenous pyelography (IVP) in detecting the associated urinary tract anomalies in children with urinary tract infection (UTI). A total of 143 cases with confirmed UTI all received renal sonography (RS), voiding cystourethrography (VCUG) and IVP, to evaluate for G-U tract anomaly. Associated G-U tract anomalies were noted in 67 cases (46.85%). No single method was adequate in detecting all abnormalities. Based on the anomalies detected, we proposed and compared two different conditions in which IVP was required. In condition A, in which IVP was performed when abnormal finding were found in RS or VCUG, 67 of 143 cases with UTI (46.85%, 67/143) were required to have IVP, among them 32 cases yielded positive results and 35 cases negative results. Two cases of duplex collecting system (DCS) were found only on IVP would be completely undetected under this proposed condition. However, when IVP was recommended and performed at the time of high grade VUR in VCUG or any abnormality in RS (condition B), 43 of 143 patients (30%, 43/143) with UTI were required to undergo IVP, yielding abnormal findings in 30 cases (70%, 30/43) and normal findings in 13. This would leave four cases of DCS undetected, including the 2 detectable only by IVP plus 2 more that showed low grade VUR on VCUG. However, these 4 cases would not result in progressive renal damage in long-term follow up.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

[Ureteropelvic junction obstruction presenting with abdominal pain: a analysis of fourteen cases].

During the past three and half years (Jan, 1984-Jun. 1987), 14 cases of ureteropelvic junction obstruction presented with abdominal pain were encountered in the Department of Pediatrics, Mackay Memorial Hospital. Eight cases were male and six female. Their ages ranged from 4 years old to 12 years old. The duration of abdominal pain lasted for several days in 5 cases, several months in 4, and several years in another 5 cases. The abdominal pain was usually recurrent. It occurred once every 2 to 6 months. The location of pain was predominantly in the left abdomen and the periumbilical area. Cramping was the most characteristic symptom. Besides abdominal pain, several cases also had vomiting or abdominal mass. Laboratory examination showed some cases to have microscopic hematuria and others pyuria. All were proved by renal ultrasonography to have varying degrees of hydronephrosis. Intravenous pyelography or retrograde pyelography also confirmed the diagnosis of ureteropelvic junction obstruction. In 9 of the 14 cases, surgical intervention was performed to correct abnormalities. Six cases were followed up regularly; all showed improvement, however, one developed ureteropelvic junction obstruction on the contralateral kidney one year later. The remaining five cases who did not receive surgical treatment continued to have recurrent abdominal pain.

Abdominal Pain↗
PubMedDate not supplied

[Relationship of chest roentgenographic features and outcome in meconium aspiration syndrome].

Aspiration of meconium may produce respiratory distress of various severity and outcome. It is the purpose of this study to evaluate the relationship between roentgenographic feature of initial chest roentgenogram (less than 10 hours old) and outcome in infants with meconium aspiration syndrome (MAS). We analyzed retrospectively the clinical data and initial chest roentgenograms of 65 infants who had MAS and who were admitted to NICU of Mackay Memorial Hospital in 1987. The incidence and the mortality rate in this hospital were 0.33% and 15.4% respectively. Infiltration was seen in 52, consolidation or atelectasis in 18, hyperinflation in 17, air leak in 11, and cardiomegaly in 4. The outcome was similar between infants with the first four features. Four infants with cardiomegaly also had other types of roentgenographic feature and PH value of initial blood gas less than 7.0, which means that their poor outcome was influenced by multiple factors. From this observation we concluded that the initial chest roentgenogram is a useful aid for the diagnosis and treatment of MAS, but it is not suitable for predicting the outcome of infants with MAS.

Female↗