Effects of anesthetics on water structure.
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Anesthetics↗
Biomedical subjects
S L Miller
Publications and source records attributed to S L Miller.
Neuroangiography with iohexol.
Iohexol is a new, nonionic water-soluble contrast agent undergoing early clinical trials in the United States. Using a double-blind, parallel format, iohexol was compared with meglumine iothalamate (60 patients) for selective cerebral angiography, and with sodium meglumine diatrizoate (40 patients) for arch aortography. Iohexol produced significantly less pain than meglumine iothalamate or sodium meglumine diatrizoate. There were no significant differences in terms of heart rate, blood pressure, or electrocardiogram (ECG) changes. Both produced a transient tachycardia and hypotension after arch aortography, but significantly less so with iohexol. No significant complications occurred. Film quality was comparable between contrast agents except for diminished motion artifacts with iohexol. Iohexol appears to be a superior neuroangiographic contrast agent to current ionic drugs.
Adult↗
Choroidal osteoma.
Choroidal osteomas are benign, juxtapapillary, choroidal tumors that mandate no treatment. They occur predominantly in young (median age, 20 years) females (90%). While ophthalmoscopy and fluorescein angiography reveal suggestive ophthalmic findings, echography, plain radiography, and especially computed tomography (CT) are important in establishing the correct diagnosis. These lesions may be clinically confused with various dystrophic lesions, atypical or amelanotic malignant choroidal melanoma, metastatic carcinoma, leukemic or lymphomatous infiltrates, choroidal hemangioma, choroidal scars of the macula, and organized subretinal hemorrhage. The exclusion of the differential consideration of malignant melanoma is most important since radiation and enucleation are therapeutic possibilities. Review of the literature shows that all nine reported cases with CT scans had clearly demonstrable calcific densities in the posterior pole of the affected eye. Four other cases are reported here with a summary of the typical clinical, radiologic, and pathologic findings. The role of CT in the evaluation of choroidal osteoma and the distinctiveness of the CT findings are stressed.
Adolescent↗
Exposure to toxic air contaminants in environmental tobacco smoke: an assessment for California based on personal monitoring data.
The contribution of environmental tobacco smoke (ETS) to the exposure of adult nonsmoking Californians was determined for selected toxic air contaminants (TACs). The assessment was based on published measurements of ETS emission factors and personal exposures to volatile organic compounds. The human exposure studies were conducted in three California areas--Los Angeles, Pittsburgh/Antioch, and Woodland--between 1984 and 1990. We derived unexposed and passive population exposure distributions by randomly sampling the monitoring results for individuals classified according to exposure status (active smoker, passively exposed or unexposed to ETS during monitoring). The differences between the unexposed and passive distributions were used to estimate the ETS-only contribution for exposure to benzene, styrene, o-xylene, and m,p-xylene. Emission factors were then employed to infer the ETS-caused exposure to thirteen other compounds. The estimated arithmetic mean increments of 24-hour exposure attributable to ETS for the nonsmoking Californian population (age > or = 7) exposed to ETS are as follows (results in units of microgram m-3 exposure concentration; results using two different emission factors presented as a range): acetaldehyde 11-15; acetonitrile 7.0; acrylonitrile 0.49; benzene 1.02; 1,3-butadiene 0.75-2.3; 2-butanone 1.4; o-cresol 0.17; m,p-cresol 0.41; ethyl acrylate < 0.015; ethylbenzene 0.49-0.64; formaldehyde 6.5-8.2; n-nitrosodimethylamine 0.0028; phenol 1.4; styrene 0.36; toluene 3.1-3.2; o-xylene 0.77; m,p-xylene 0.99. The 90% confidence limits on these estimates due to the limited sample size in the studies are roughly x/ divided by 6. For four widely studied compounds, ETS is estimated to contribute the following percentages to the total inhalation exposure of all nonsmoking Californians: o-xylene 5%; m,p-xylene 3%; benzene 5%; and styrene 8%.
Adolescent↗