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Biomedical subjects

S L Matarasso

Publications and source records attributed to S L Matarasso.

15 recordsLinked to original sources

Endoscopic surgical correction of glabellar creases.

BACKGROUND: A number of alternatives exist for the temporary correction of glabellar creases and frown lines. The traditional "open" operative procedure has often involved a large incision to gain access to the depressor muscles that are responsible for the deformity. While useful for patients with multiple or more significant deformities, patients with isolated glabellar creases and frown lines have been reluctant to consider an extensive surgical procedure, with its attendant morbidity, for an isolated problem. OBJECTIVE: The purpose of this report is to describe a new technique of endoscopic corrugator muscle resection, without the need for the traditional lengthy scalp incision. METHODS: Traditional criteria for patient selection was employed. A series of 10 consecutive patients with vertical mid-forehead glabellar-eyebrow frown lines were treated by endoscopic corrugator muscle resection and evaluated. RESULTS: The procedure was efficacious in reducing the frown-muscle complex prominence and rhytids in the mid-forehead area. Circumstances of heavy folds, hyperactive muscle function, or premature furrows in patients with good skin tone appear to be most suitable for this technique. CONCLUSION: With the introduction of a more acceptable, less problematic surgical solution, deformities in the forehead-eyebrow area can be readily addressed surgically. The procedure is a cost-effective alternative to temporary techniques improving aesthetic problems in the forehead-eyebrow area.

Adult

Chemical peels. Trichloroacetic acid and phenol.

Chemical peeling is the most widely used modality for treating photoaged skin. The classification, indications, techniques, complications, and histology of two of the most widely used peeling agents, trichloroacetic acid and phenol, are presented.

Chemexfoliation

Wood's lamp for superficial chemical peels.

BACKGROUND: Superficial chemical peels are being used with increasing frequency in the treatment of photoaging. OBJECTIVE: Our purpose was to develop a marker to indicate when all areas of skin have been treated and avoid reliance on a map or operator recall. METHODS: With a Wood's lamp (maximum output 365 nm) and addition of salicylic acid and fluorescein sodium, solutions that are readily available, the progress of the superficial chemical peel can be visualized. RESULTS: Wood's lamp accentuates epidermal pigment and therefore highlights dyschromia that will respond to a superficial chemical peel. Similarly, salicylic acid and fluorescein sodium fluoresce when viewed under Wood's lamp examination. CONCLUSION: When fluorescent compounds are incorporated into a superficial chemical peel, then fluorescence can accurately locate skip areas, minimize inadvertent overlayering, and thereby avoid deeper penetration.

Chemexfoliation

Introduction to cosmetic surgery.

Patients seeking information on improving their appearance is becoming increasingly popular, and dermatologists are often the first to be consulted. It is therefore important for the dermatologist to acknowledge the patient's concerns and if they are not willing or capable of addressing these needs, one should refer them to an appropriate health care provider. However, if the dermatologist does elect to provide a service, it is crucial not only to obtain the knowledge and technical skill but the mechanism to select and recognize who is an acceptable candidate from both anatomic and psychological perspectives.

Attitude of Health Personnel

Comparison of skin hooks and Foley catheters for immediate tissue expansion.

BACKGROUND: Immediate tissue expansion has been reported to expand skin sufficiently to permit primary closure of large facial defects up to 5 cm in diameter. OBJECTIVE: We wished to evaluate and compare skin hooks with foley catheters in producing tissue expansion. METHODS: Seven patients with post-Mohs surgery defects measuring 3.0 to 5.5 cm in diameter and located on scalp, temple, or forehead skin were treated with immediate tissue expansion. RESULTS: Immediate tissue expansion provided a 16 to 36% increase in the tissue available for closure, over and above what was achieved by undermining alone. In each case, adequate stretching of skin was achieved to permit primary closure relatively easily, which was not possible with undermining alone. Skin hooks were found to be equivalent to foley catheters in their ability to produce tissue expansion. At the one year follow-up visit, some spreading of the scar was noted, ranging from 1 to 7 mm, which appears in part to be related to the degree to which the skin was expanded. CONCLUSION: These findings support the concept that immediate tissue expansion is a separate and distinct process from undermining, which provides additional tissue for reconstructive surgery.

Aged

Ichthyosiform sarcoidosis: report of a case.

Sarcoidosis is a systemic granulomatous disease of undetermined cause, with cutaneous manifestations occurring in up to 35 percent of patients. We report a case of the rare form of ichthyosiform sarcoidosis occurring in a young black woman.

Adult

Chemical face peels.

Application of caustic chemicals to improve cosmesis and reverse actinic damage has been used for centuries. Although still not an exact science, it was not until the latter part of this century that peeling became more systematized. The indications, patient selection, armamentarium, histology, comprehension of the mechanisms of action, and safety parameters of peels have only recently become more extensively defined. Phenol, when used in the Baker's formula, provides the most dramatic results but also holds the most potential for systemic complications. Ideally suited for fair-skinned women, a phenol peel can provide substantial improvement in rhytidosis and actinic damage. Although the results of medium-depth peels approach those of Baker's peels, they are not quite as profound. Use of TCA and the medium-depth peels has filled an important gap between deep and superficial peels, however. Also ideal for light complexions, this category of peels lightens pigmentary problems and improves rhytides with minimal potential for systemic toxicity; however, local complications, including scarring and pigmentary anomalies, should not be underestimated. [table: see text] Superficial peels do not effectively eradicate the ravages of time and sun, but when done repetitively, they do improve pigmentary irregularities and may improve some minor surface changes and thus impart a fresher appearance to facial skin. Although pigmentary changes can occur, superficial peels are relatively safe, and maximal results can be achieved with serial applications. Peels have been categorized by patient indications and the corresponding depth of peeling required for improvement (Table 4). The depth is determined in turn by a host of factors (Table 5). Neither the classification scheme nor the peel process should be viewed dogmatically. Patients will often benefit from the concurrent use of different skin preparations and wounding agents. Localized gradations can be achieved not only with occlusion but also by employing different solutions as well as different concentrations of the same solution and skin preparation. Selection of the appropriate technique relies on critical analysis of the skin defect one wishes to treat balanced against the risks of treatment. The final protocol should be individualized for the needs of each patient. Despite heightened public awareness of the harmful effects of ultraviolet radiation, actinically damaged skin is no longer a problem restricted to an older-patient population. Fueled by the lay press and practitioners, there is a growing patient demand for chemical peels. Chemical peels alone or combined with ancillary aesthetic procedures can provide a dramatic improvement in facial appearance. The potential for improved cosmesis is not without inherent risk, however.(ABSTRACT TRUNCATED AT 400 WORDS)

Chemexfoliation

The role of chemical peeling in the treatment of photodamaged skin.

Management of the aging face involves evaluation of the degree of solar elastosis, rhytidosis, and the structural changes associated with senescent skin. Chemical facial exfoliation is divided into deep, medium, and superficial based upon depth of penetration of the caustic agent used. Knowledge of the appropriate indications and technique are essential in obtaining optimal clinical results.

Chemexfoliation

A regional approach to patient selection and evaluation for liposuction.

Any area of the body where the deformity is due to regional excess fat and where there is overlying good skin tone is presumably amenable to body contouring by liposuction. It is an understandable temptation to attempt to remove large quantities of fat without major surgery and without noticeable scars. With experience, the surgeon will be able to estimate preoperatively the amount of fat that should be removed. However, liposuction is a procedure that requires conservatism because overzealous fat removal can generally leave unsightly permanent sequelae. Careful patient selection and proper identification of the correct indications of the technique are of paramount importance in achieving good aesthetic results and in avoiding complications. The ideal candidate is young, with good skin tone, moderate localized fatty deposits, and realistic expectations. There is certainly a wide range of patients who will benefit from the use of liposuction, and the average patient with less-than-ideal indications is more commonly encountered. The poor candidate is obese or has a significant deformity, poor skin tone, and, ironically, the most unrealistic expectations. Old age is not an absolute contraindication, although with increased age there is a concomitant decrease in elastic fibers, resulting in decreased capability to adapt a new contour. However, many patients "past their prime" will also have an acceptable cosmetic result and are particularly pleased with their changed, clothed silhouette. Appropriate patient selection, appreciation of the underlying anatomy, and judicious surgical technique are all essential for optimal results and patient satisfaction. Liposuction as described, either alone or as an adjunct to other procedures, allows for optimal aesthetic correction of figure faults due to adipose tissue.

Adipose Tissue

Zosteriform metastasis: case presentation and review of the literature.

In contrast to benign tumors, malignant tumors, by definition, are characterized by the potential of giving rise to metastases. Albeit infrequently, skin metastases do occur, and their clinical appearance varies over a wide morphologic spectrum. We present the case of a 65-year-old male with zosteriform metastasis secondary to bronchogenic adenocarcinoma. A review of cutaneous metastasis is presented with emphasis on dermatomal distribution and possible mechanisms of dissemination.

Adenocarcinoma

Nucleation-controlled aggregation of deoxyhemoglobin S. Effect of organic phosphates on the kinetics of aggregation of deoxyhemoglobin S in concentrated phosphate buffer.

The kinetics of the aggregatin of deoxyhemoglobin S in concentrated phosphate buffer were studied turbidimetrically in the presence of organic phosphates. The addition of inositol hexsphosphate shortened the delay time by 35-80%, the range depending on the hemoglobin concentration. The logarithmic plot of delay time versus hemoglobin concentration in 1.85 M potassium phosphate buffer, pH 7.34, showed a linear relationship with a slope (n value) of 2.5 +/- 0.14 in the absence of inositol hexaphosphate, while the slope was decreased to 2.1 in the presence of inositol hexaphosphate. The turbidity (A700) of aggregates per g deoxy Hb S was found to be lower in the presence of inositol hexaphosphate than in the absence of inositol hexaphosphate. The solubility of deoxy Hb S was decreased by inositol hexaphosphate. 2,3-Diphosphoglyceric acid also showed an effect similar to that of inositol hexaphosphate. However, if the pentacyclohexylammonium salt of diphosphoglyceric acid were used, the delay time was increased significantly. The opposite effect of the pentacyclohexylammonium salt of diphosphoglyceric acid on the delay time was found to be attributed to the anti-gelation effect of the pentacyclohexoxylammonium ion. The difference in the effect of inositol hexaphosphate and diphosphoglyceric acid on the delay time appears to be related to their effect on the solubility of deoxy Hb S.

Diphosphoglyceric Acids