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Biomedical subjects

S L Khankin

Publications and source records attributed to S L Khankin.

At least 19 recordsLinked to original sources
PubMed1994

[Orthograde intestinal lavage in the preparation for colonoscopy].

Thirty-eight proctological patients were prepared for colonoscopy by drinking 2l of aqueous solution of polyethylene glycol-4000 and electrolytes, so that additional purgatives, cleansing enemas, and waste-free diet are not needed. Control of hemodynamics, clinical and biochemical blood tests, and plasma electrolyte content revealed no significant changes in these parameters after preparation for the examination. Colonoscopy was conducted to a full measure in 94% of cases. This method was preferred rather than the use of purgatives and enemas by 82% of patients. Intestinal lavage with polyethylene glycol and electrolyte solution is a simple and effective method, it is convenient for the patient and does not cause marked side effects.

Administration, Oral↗
PubMed1991

[Hyperplastic changes in the mucosa in colon cancer].

67 segments of rectum and sigmoid removed surgically because of carcinoma were examined: the surface of intestinal mucosa stained with methylene-blue was studied in order to determine the number and localization of focal changes in the macroscopically unchanged areas. Colon microscopy was performed clinically in 24 patients with carcinoma of the rectum and in 24 control individuals. 28 hyperplastic polyps and 1037 microscopic hyperplastic foci were found in operative material. An active metabolism is established by means of electron autoradiography in the cells of hyperplastic focus. Areas of dysplastic epithelium were rarely found in big hyperplastic polyps. Areas of diffuse hyperplasia (transitional mucosa) with crypt deepening and presence of a high number of goblet cells were found near tumour. A certain role of hyperplastic processes in carcinogenesis is forwarded. Numerous microscopic changes in the mucosa epithelium may testify against the carcinoma development de novo.

Adult↗
PubMed1990

[Development of metachronous tumors of the colon].

Clinical and endoscopic evidence gained at the follow-up of 93 patients with metachroneous colon cancer suggests that at present there is minimal change to predict the occurrence, time of onset and site of emergence of the secondary tumors as the latter grow rapidly and rise in macroscopically free-of-tumor colon segments. In some patients metachroneous tumors were associated with long histories of benign adenomas. The authors hold that patients operated on for colon cancer should remain under life-long clinical and endoscopic observation.

Adult↗
PubMed1989

Microendoscopic features of the surface epithelium in patients with colonic tumors.

Vital studies of the colonic mucosa in 127 patients using the method of colonomicroscopy have allowed us to establish that the surface epithelium has a heterogeneous structure. It was possible to single out three main types of cell organization. Correlation has also been detected between types of cell organization of surface epithelium and morphological structure of the most common neoplasms of the colon.

Adult↗
PubMed1984

Endoscopic microscopy of the colon.

The authors analyse the results of endoscopic colonomicroscopy at various magnifications in 250 patients. A study of dye absorption in different histological types of colonic tumor made it possible to establish that chromocolonoscopy is an effective method in diagnosing and differentiating some types of tumors and hyperplastic changes in the mucosa of the colon. Adenomas with severe dysplasia of the glandular epithelium, and tumors with a structure of an adenocarcinoma do not readily accept vital staining.

Colonic Neoplasms↗