The effects of BC, 4CMB and 4HMB on meiosis in yeast cells.
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Benzyl Compounds↗
Biomedical subjects
S L Kelly
Publications and source records attributed to S L Kelly.
11Beta-hydroxysteroid dehydrogenase activity in progesterone biotransformation by the filamentous fungus Cochliobolus lunatus.
Progesterone biotransformation was examined in relation to hydroxylating and dehydrogenating enzymes of Cochliobolus lunatus. 11beta-hydroxysteroid dehydrogenase activity (11beta-HSD) was located in cytosolic fraction and was NADP-dependent, inducible by progesterone and apparently uni-directional. Several inhibitors of 11beta-hydroxysteroid dehydrogenase were tested; furosemide, glycyrrhizic-acid and carbenoxolone did not influence the dehydrogenation of 11beta-hydroxy-4-pregnene-3,20-dione to 4-pregnene-3,11,20-trione, although grapefruit juice significantly reduced the rate of progesterone hydroxylation.
11-beta-Hydroxysteroid Dehydrogenases↗
Amphotericin B resistant isolates of Cryptococcus neoformans without alteration in sterol biosynthesis.
Amphotericin B resistant mutants of Cryptococcus neoformans were isolated accumulating mainly ergosterol. Cross-resistance to azole antifungals was not observed. Together with previous data this indicates that at least three categories of amphotericin B resistance can arise: sterol mutants, amphotericin B and azole cross-resistant mutants and amphotericin B resistant mutants with no azole cross-resistance.
Amphotericin B↗
Inhibition and interaction of cytochrome P450 of Candida krusei with azole antifungal drugs.
Candida krusei has become an increasingly important invasive pathogen, particularly in AIDS patients and is highly resistant to fluconazole. In vitro growth inhibition studies revealed that fluconazole and ketoconazole were approximately 800- and 19-fold less inhibitory than itraconazole. The inhibition and interaction of itraconazole, fluconazole and ketoconazole with the sterol 14 alpha-demethylase of C. krusei was studied using in vitro ergosterol biosynthesis and difference spectroscopy, respectively. Both itraconazole and ketoconazole inhibited in vitro ergosterol biosynthesis at lower concentrations than fluconazole. All three drugs interacted with microsomal P450 and interfered in the binding of carbon monoxide to P450 in direct proportion to their inhibitory effect on ergosterol biosynthesis in cell-free extracts. The slightly lower affinity of sterol 14 alpha-demethylase for fluconazole compared with itraconazole and ketoconazole is only partially responsible for poor activity of fluconazole on C. krusei.
Antifungal Agents↗