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Biomedical subjects

S L Bratton

Publications and source records attributed to S L Bratton.

47 records · Page 3Linked to original sources
PubMed1995

Severe dog bites in children.

OBJECTIVE: We evaluated children less than 16 years of age who had dog bite injuries that resulted in hospitalization or death to determine the typical characteristics of the children, the dogs, and the injuries suffered. DESIGN: Retrospective chart review. SETTING: Three large city hospitals including Harborview Medical Center, Seattle, Washington; Children's Mercy Hospital, Kansas City, Missouri; and Mary Bridge Hospital, Tacoma, Washington. METHODS: Charts were reviewed for patient demographic data and canine data. Hospitalization data included total length of stay, need for intensive care, Injury Severity Score, the nature and extent of the injuries, procedures performed, complications, and outcome. RESULTS: Forty cases were reviewed. Most children were boys (60%) and were white (87%). The median age was 50 months. There were three deaths. Most dogs were medium-sized or large breeds and were familiar to the victim. The average hospital stay was 6 days (SD = 5), and 12 (30%) patients required a stay in the intensive care unit. Injuries to the face, head, and neck area were most common (82%). Major surgical procedures included craniotomy, exploration of the neck or abdomen, ocular procedures, and repair of fractures. CONCLUSIONS: Severe dog bites in children occur most frequently in those younger than 5 years old and involve the head and neck. Large dogs that are familiar to the child are usually involved. Young children should be closely supervised when around any dog.

Adolescent↗
PubMed1995

Using characteristic changes in laboratory values to assist in the diagnosis of hemorrhagic shock and encephalopathy syndrome.

OBJECTIVES: (1) To determine whether the laboratory abnormalities in hemorrhagic shock encephalopathy syndrome (HSES) follow a characteristic pattern of evolution; and (2) to describe the clinical characteristics and outcome of this group of children. DESIGN: Retrospective review of hospital records. SETTING: Pediatric intensive care unit in an academic children's hospital. PATIENTS: Seventeen children who received the diagnosis of HSES. MEASUREMENTS: (1) To support the diagnosis of HSES, the following laboratory tests were obtained: creatine phosphokinase, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, anemia, thrombocytopenia, coagulation abnormalities, and a metabolic acidosis; and (2) patient characteristics at the time of admission and during the illness and patient outcome were recorded. RESULTS: The median time for laboratory abnormalities in HSES to reach the most aberrant levels was 1.2 to 1.4 days. After reaching maximal deviation, the laboratory values gradually returned to normal. The severity of laboratory abnormalities was not predictive of mortality. All patients were comatose, had seizures, and required fluid resuscitation. Respiratory failure occurred in 12 (71%) of 17 patients. Vasopressor infusions were used for 8 (47%). Viral cultures were performed in 15 patients and were positive in 8 (53%). Eleven (64%) patients survived. CONCLUSIONS: The laboratory abnormalities that are characteristic of HSES follow a distinctive pattern of evolution during the course of the illness. Although the sensitivity, specificity, and predictive value of this pattern of laboratory abnormalities are not known, it might provide a useful tool in diagnosing HSES and excluding other illnesses. Viral illness is common in HSES. The severity of illness and mortality in this group of patients is similar to other descriptions of HSES.

Brain Diseases↗
PubMed1994

Serial neurologic examinations after near drowning and outcome.

OBJECTIVE: We evaluated serial neurologic examinations after warm water near drowning to determine how rapidly survivors with poor neurologic outcome could be identified. RESEARCH DESIGN: Retrospective chart review. SETTING: University-affiliated pediatric hospital. PATIENTS: Forty-four children admitted to the pediatric intensive care unit with an abnormal mental status after near drowning during a 5-year period. Follow-up was a minimum of 6 months. INTERVENTIONS: None. MEASUREMENTS: A 14-point coma scale was used to evaluate both cortical and brain-stem function at the time of hospital admission and then daily afterward. The Mann-Whitney U Test was used to compare patients grouped as having satisfactory outcomes (those who returned to their presubmersion baseline or had very mild deficits) and unsatisfactory outcomes (total custodial care or death). Significance was defined as P < .05. CONCLUSION: All satisfactory survivors were sufficiently awake to have spontaneous, purposeful movements 24 hours after near drowning and had normal brain-stem function. All children without spontaneous, purposeful movements and normal brain-stem function 24 hours after near drowning suffered severe neurologic deficits or death. In this retrospective investigation of 44 children, the cortical examination 24 hours after warm water near drowning distinguished satisfactory survivors from children who required total custodial care or died.

Adolescent↗
PubMed1994

Routine chest radiographs following repositioning of endotracheal tubes are necessary to assess correct position in pediatric patients.

Attempts to correctly reposition endotracheal tubes (ETTs) are not always successful in pediatric patients, even when chest radiographs (CXRs) are measured to determine the distance that the ETT deviates from the correct position. We determined the frequency of continued ETT malposition after repositioning in a pediatric intensive care unit (PICU). Forty children with malpositioned ETTs were identified during a 4-month period. After repositioning, ten (25 percent) continued to be malpositioned on the next CXR. Of 47 children with correctly positioned ETTs, only one ETT (2 percent) was found to be incorrectly positioned on the next routine CXR obtained 24 h later. The difference in frequency of ETT malposition between these two groups of children is significant (p < 0.0001). The children were similar in weight and age. Despite repositioning based on measurements taken from a CXR, a large percentage of pediatric patients had continued ETT malposition. However, after radiographic documentation of correct position, we demonstrated that significant movement was uncommon. Routine confirmation of ETT position by CXRs should be considered after repositioning ETTs in pediatric patients.

Critical Illness↗
PubMed1992

A child with valproic acid-associated carnitine deficiency and carnitine-responsive cardiac dysfunction.

Valproic acid enhances renal losses of carnitine esters and leads to decreased plasma free carnitine concentrations in many patients receiving valproic acid therapy. However, decreased serum carnitine levels are of unclear pathologic significance, and most children manifest no symptoms of carnitine deficiency. We report a child with valproic acid-associated carnitine deficiency who had severe cardiac dysfunction develop that resolved with carnitine replacement therapy.

Carnitine↗
PubMedDate not supplied

Spontaneous pneumomediastinum.

A case of spontaneous pneumomediastinum with cervical emphysema is reported. Spontaneous pneumomediastinum may complicate processes that decrease pulmonary interstitial pressure or increase intraalveolar pressure leading to alveolar rupture. Free air may then tract along blood vessels and decompress into the soft tissues of the neck. Clinical symptoms include neck and chest pain, dysphonia, and shortness of breath. Care is supportive unless the patient has a history of trauma or foreign body aspiration. Symptoms typically resolve within days.

Child, Preschool↗
PubMedDate not supplied

A comparison of oral transmucosal fentanyl citrate and oral hydromorphone for inpatient pediatric burn wound care analgesia.

The ideal oral wound care analgesic for children should be palatable, provide potent analgesia of rapid onset and short duration, and require minimal, yet appropriate, monitoring. With use of a double-blinded crossover design, we compared the efficacy and safety of oral transmucosal fentanyl citrate (OTFC) (approximately 10 micrograms/kg) with the efficacy and safety of oral hydromorphone (60 micrograms/kg) in 14 pediatric inpatients (ages 4 to 17 years) undergoing daily burn wound care in a ward setting. Pulse oximetry, vital signs, side effects, patient pain scores, and observer scores for cooperation, anxiety, and sedation were recorded. Pulse oximetry, vital signs, cooperation, sedation, incidence of nausea or vomiting, and the amount of time it took to resume normal activities were similar in both treatment groups. OTFC resulted in improved pain scores before wound care and improved anxiolysis during wound care, but at other points it was similar in effect to hydromorphone. We conclude that OTFC is a safe and effective analgesic, that it may provide minor improvements in analgesia and anxiolysis compared with hydromorphone, and that it offers a palatable alternative route of opioid administration without intravenous access for wound care procedures in children.

Administration, Oral↗
PubMedDate not supplied

Constitutive synthesis of heat shock protein (72 kD) in human peripheral blood mononuclear cells: implications for use as a clinical test of recent thermal stress.

There is no clinical laboratory marker to enhance the diagnosis of recent thermal stress in humans. The 72 kD heat shock protein, HSP 72, which is rapidly synthesized after heat stress could be useful in the diagnosis of illnesses associated with heat stress. In humans HSP, 72 is rapidly synthesized after thermal stress; however, conflicting data suggest it may also undergo low level constitutive synthesis. If HSP 72 is constitutively synthesized, a semi-quantitative test will be necessary to detect recent heat stress; if not, a qualitative test would be sufficient, peripheral blood mononuclear cells were chosen for this investigation because they can be isolated from a small sample (clinically acceptable) of blood. Following heat stress Western analysis and autoradiography of one- and two-dimensional electrophoresis samples demonstrated low levels of HSP 72 in unstressed cells. HSP 72 increased with heat stress, and remained elevated for up to 48 h. HSP 72 mRNA was detectable in small amounts in nonheat stressed cells. Heat stress increased HSP 72 mRNA 1 and 2 h after stress and remained elevated for 6 h. HSP 72 persists long enough to be potentially useful as a diagnostic probe of recent heat injury; however, a semi-quantitative assay will be necessary.

Biomarkers↗